Speaker Bio

Dr. Puxiang Lai is a Tenured Associate Professor at The Hong Kong Polytechnic University, Department of Biomedical Engineering. Dr. Lai’s research interests focus on deep-tissue optical focusing, imaging, stimulation, and treatment. Current research projects include, but are not limited to, wavefront shaping, photoacoustic imaging, neuron stimulation, computational optics, and artificial intelligence. His research has fueled more than 80 top journal publications, such as Nature Photonics, Nature Communications, Light: Science and Applications, PhotoniX, The Innovation, and Advanced Science. He has been invited to give more than 80 seminars or invited talks worldwide. Since 2015, his research has been continuously supported by National Natural Science Foundation of China (NSFC), Hong Kong Research Grant Council (RGC), Hong Kong Innovation and Technology Commission (ITC), Department of Science and Technology of Guangdong Province, and Shenzhen Science and Technology Innovation Commission (STIC). Dr. Lai was awarded the 12^th National (Youth) Talent, the 2016-2017 Hong Kong RGC Early Career Award, the 2018 Hong Kong Polytechnic University Faculty of Engineering Research Grant Achievement Award, the 2019 PolyU K.C. Wong Belt and Road Visiting Fellowship Award, and the 2020 Hong Kong Polytechnic University Faculty of Engineering Faculty Research Award. As a recognition for his contribution to the field, Puxiang serves as Associate Editor or Editor for quite a few academic journals, such as The Innovation, Advanced Photonics Nexus, Journal of Innovative Optics in Health and Science (JIOHS), Novel Technology and Devices (MEDNTD), and Journal of Visual Computing for Industry, Biomedicine, and Art (VCIBA),

赖溥祥博士是香港理工大学生物医学工程系长聘副教授，生物光子学实验室创始人和主任。赖博士长期致力于声光结合及其在生物医学成像、治疗以及操控领域的应用研究，在诸如光声成像、散射光聚焦、光遗传、光计算、人工智能等领域在过去的十多年开展了大量原创和前瞻性的工作，成果得到了国际同行的初步关注与肯定，以第一作者或者通讯作者在Nature Photonics, Nature Communications, Light: Science and Applications, PhotoniX, The Innovation, and Advanced Science等国际知名学术期刊发表论文80余篇，多次获得国际会议最佳论文荣誉。2017年起主持国家自然科学基金、香港特别行政区大学教育资助委员会、香港创新科技署、广东省科技厅、深圳市科技创新委员会等基金多项。赖博士2016年入选国家高层次人才（青年）计划，香港2016-2017年度杰出青年学者，2018 年香港理工大学工学院杰出科研基金奖，2019年王宽城“一带一路”访问学者，2020年香港理工大学工学院卓越科研奖。目前担任中国光学学会生物医学光子学分会常委，中国生物医学工程学会生物医学光子学分会委员，以及一系列学术期刊副主编或编委，比如The Innovation, Advanced Photonics Nexus, Journal of Innovative Optics in Health and Science (JIOHS), Novel Technology and Devices (MEDNTD), 以及 Journal of Visual Computing for Industry, Biomedicine, and Art (VCIBA)。

Abstract

The usage of light has considerably reshaped the landscape of biomedicine in the past decades from imaging, sensing, treatment, stimulation, to control. The applications, however, are limited to superficial layers beneath sample surface or compromised resolution at depths due to the inherent nature of strong optical scattering in tissue. Many approaches have been proposed to tackle this challenge, such as switching to longer wavelengths to have lower tissue scattering coefficients, converting diffused light into not-so-scattered sound at the signal detection side, etc. In this talk, we will focus on wavefront shaping, a strategy of suppressing scattering by pre-compensating for the scattering-induced phase distortions, and photoacoustic imaging, a strategy of suppressing scattering at the side of signal detection. We will present the basics of working principle and our continuing endeavors in these directions. Challenges and roadmaps towards real deep-tissue applications will also be discussed.

光的使用在过去二三十年极大地改变了生物医学的形态，从成像、传感、治疗、刺激到控制。然而由于生物组织光折射因子的天然空间不均匀性，光在生物组织中的传播受到很强的散射，导致了纯光学技术穿透深度和空间分辨率“鱼和熊掌无法两全”，目前的高分辨率光学应用仅限于样品的浅表层。如何实现散射光的聚焦并开展应用，是人们期盼但很有挑战性的目标，人们提出了许多方法来应对这一挑战，例如切换到更长的波长以具有更低的组织散射系数，在信号检测端将漫射光转换为不那么散射的声音等。本报告将回顾过去十多年我们在光-声结合和光学波前整形技术等方面展开的诸多探索，以及在生物组织操控、成像、光学计算以及人工智能等领域的应用尝试。虽然尚有诸多不足，但相信未来的技术和硬件设备的更新，加之持续不断的努力会让我们离最终的活体生物医学应用目标越来越近，且有可能激发新的应用灵感，在不远的将来带来全新的理念和机遇。