研究领域（方向）

主要从事天然药物化学的研究与开发。主要是从中草药、药用植物、微生物等天然药物资源中寻找结构新颖、活性显著的天然产物，并以此为先导化合物，通过化学结构改造和优化等方法从中发现高效低毒的前药分子。

个人及工作简历

科研项目

学术及科研成果、专利、论文

发表SCI研究论文20余篇，其中以第一作者发表10篇。

(1) Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Gang Chang, Lei Zhang, Xinxin Zhanga, Hui Zhang, Zengjun Guo, Monoterpene indole alkaloids with acetylcholinesterase inhibitory activity from the leaves of Rauvolfia vomitoria, Bioorganic Chemistry, 2020, 102: 104136.

(2) Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Xincai Hao, Xi Zheng, Hui Zhang, Xinxin Zhang, Zengjun Guo, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, Phytochemistry, 2020,177: 112450.

(3) Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Yi Hao, Yu Zhang, Yingxu Zhang, Muhammad Khurm, Xinxin Zhang, Zengjun Guo, Peraksine derivatives with potential anti-inflammatory activities from the stems of Rauvolfia vomitoria, Fitoterapia, 2020, 146, 104704.

(4) Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Xingbin Wang, Xinxin Zhang, Zengjun Guo, Cytotoxic Yohimbine-Type Alkaloids from the Leaves of Rauvolfia vomitoria, Chemistry & Biodiversity, 2020, 17, e2000647.

(5) Guanqun Zhan, Junfei Zhou, Junjun Liu, Jinfeng Huang, Hanqi Zhang, Rong Liu, Guangmin Yao*, Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata, Journal of Natural Products, 2017, 80(9): 2462-2471.

(6) Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa, Guangmin Yao*, Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors, European Journal of Medicinal Chemistry, 2017, 127: 771-780.

(7) Guanqun Zhan, Junfei Zhou, Rong Liu, Tingting Liu, Guoli Guo, Jianping Wang, Ming Xiang, Yongbo Xue, Zengwei Luo, Yonghui Zhang, Guangmin Yao*, Galanthamine, plicamine, and secoplicamine alkaloids from Zephyranthes candida and their anti-acetylcholinesterase and anti-inflammatory activities, Journal of Natural Products, 2016, 79(4): 760-766.

(8) Guanqun Zhan, Junfei Zhou, Tingting Liu, Guijuan Zheng, Haji Akber Aisa, Guangmin Yao*, Flavans with potential anti-inflammatory activities from Zephyranthes candida, Bioorganic & Medicinal Chemistry Letters, 2016, 26(24): 5967-5970.

(9) Guanqun Zhan#, Xiaolan Qu#, Junjun Liu, Qingyi Tong, Junfei Zhou, Bin Sun, Guangmin Yao*, Zephycandidine A, the first naturally occurring imidazo[1,2-f]phenanthridine alkaloid from Zephyranthes candida, exhibits significant anti-tumor and antiacetylcholinesterase activities, Scientific Reports, 2016, 6: 33990.

(10) Qi Ye#, Jue Jiang#, Guanqun Zhan#, Wanyao Yan, Liang Huang, Yufeng Hu, Hexiu Su, Qingyi Tong, Ming Yue, Hua Li, Guangmin Yao*, Yonghui Zhang*, Hudan Liu*, Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia, Scientific Reports, 2016, 6: 26510

联系方式

电子邮箱：gq,zhan@163.com; zhanguanqun@mail.xjtu.edu.en

联系电话：13572975056

个人主页：https://gr.xjtu.edu.cn/web/zhanguanqun

联系地址：1、陕西省西安市雁塔区雁塔西路76号（雁塔校区）

2、陕西省西安市中国西部科技创新港（创新港校区）