2024年

 

121. Xunan Jing, Daomeng Liu, Ning Zhang , Xiaoping Zhao, Jiali Wang , Daquan Wang , Wenchen Ji, Junjun She, Lingjie Meng*, Engineering Two-dimensional tungsten-doped molybdenum selenide transformed conformational nanoarchitectonics: Trimodal therapeutic nanoagents for enhanced synergistic Photothermal/ Chemodynamic/ Chemotherapy of breast carcinoma, Journal of Colloid and Interface Science, 2024, 678, Part C, 646-657

 

Two-dimensional transition metal dichalcogenides (TMDCs) exhibit promising photothermal therapy (PTT) and chemodynamic therapy (CDT) for anti-tumour treatment. Herein, we proposed an engineering strategy to regulate the lattice structure of tungsten-doped molybdenum selenide (MoxW1−xSe2) transformed conformational nanoarchitectonics using a microwave-assisted solvothermal method for enhancing peroxidase (POD)-like catalytic performance by adjusting the ratio of molybdenum (Mo) and tungsten (W). Furthermore, the optimised Mo0.8W0.2Se2 nanoflakes surface was modified with chitosan (CHI) for improved biocompatibility and nanocatalytic efficacy, then the obtained CHI-Mo0.8W0.2Se2 subsequently loaded the chemotherapeutic drug mitoxantrone (MTO) for enhanced 4 T1 cells killing ability, shortly denoted as CHI-Mo0.8W0.2Se2-MTO for PTT-augmented CDT and chemotherapy (CT). A series of performance validations successfully showed that electrons tend to transfer from W to Mo in CHI-Mo0.8W0.2Se2, which resulted in superior POD-like activity (Km = 0.038 mM) of CHI-Mo0.8W0.2Se2 compared with that of horseradish peroxidase. Furthermore, CHI-Mo0.8W0.2Se2-MTO with excellent photothermal conversion efficiency (PCE=63.2 %) in the near-infrared (NIR) region could further promote endogenous •OH generation and MTO controlled release within solid tumours. In vivo studies confirmed the successful achievement of synergistic therapeutic effects (tumour inhibition rate of over 90 %) with minimised side effects. Versatile therapeutic nanoagents hold great potential for personalised therapy of breast cancer and will find their way to the pharmaceutical field.

 

 

120. Zhi Wang, Yu Zhou, Ying Hao, Zhiqin Zhao, Anran Gao, Huili Ma*, Peijuan Zhang, Qifei Shen, Ruohan Xu, Yanzi Xu, Dongfeng Dang*, Lingjie Meng*, One Stone Two Birds: High Brightness AIE Photosensitizers for Super-Resolution Imaging and Photodynamic Therapy, Nano Lett. 2024, 24, 10, 3005–3013

 

Most aggregation-induced emission (AIE) luminogens exhibit high brightness, excellent photostability, and good biocompatibility, but these AIE-active agents, which kill two birds with one stone to result in applications in both stimulated emission depletion (STED) super-resolution imaging and photodynamic therapy (PDT), have not been reported yet but are urgently needed. To meet the requirements of STED nanoscopy and PDT, D-A-π-A-D type DTPABT-HP is designed by tuning conjugated π spacers. It exhibits red-shifted emission, high PLQY of 32.04%, and impressive 1O2 generation (9.24 fold compared to RB) in nanoparticles (NPs). Then, DTPABT-HP NPs are applied in cell imaging via STED nanoscopy, especially visualizing the dynamic changes of lysosomes in the PDT process at ultrahigh resolution. After that, in vivo PDT was also conducted by DTPABT-HP NPs, resulting in significantly inhibited tumor growth, with an inhibition rate of 86%. The work here is beneficial to the design of multifunctional agents and the deep understanding of their phototheranostic mechanism in biological research.

 

 

119.Yanzi Xu, Jianyu Zhang, Zhi Wang, Peijuan Zhang , Zichen Zhang , Zhiwei Yang , Jacky W.Y. Lam , Ryan T.K. Kwok , Lingjie Meng*, Dongfeng Dang*, Ben Zhong Tang*, Water-soluble AIE photosensitizer in short-wave infrared region for albumin-enhanced and self-reporting phototheranostics, Biomaterials, 2025, 314, 122847

 

Organic photosensitizers (PSs) play important roles in phototheranostics, and contribute to the fast development of precision medicine. However, water-soluble and highly emissive organic PSs, especially those emitting in the short-wave infrared region (SWIR), are still challenging. Also, it's difficult to prepare self-reporting PSs for visualizing the treatment via stimulated emission depletion (STED) nanoscopy. Thus, in this work, a water-soluble molecule of DTPAP-TBZ-I with aggregation-induced emission features is designed for the self-reporting photodynamic therapy (PDT) in an ultra-high resolution. In contrast to single molecule, its complex (DTPAP-TBZ-I@BSA) shows much enhanced fluorescence properties and reactive oxygen species (ROS) generation in SWIR window. Their photoluminescence quantum yield is determined to be ∼20.6 % and the enhancement of ROS generation is ∼18-fold. During the PDT, immigration of the complex from cytoplasm to nucleus is also observed via STED nanoscopy with a resolution of 66.11 nm, which allows self-report in the PDT treatment. DTPAP-TBZ-I@BSA is finally utilized for the imaging-guided PDT in vivo with a tumor inhibition rate of 84 %. This is the first work in albumin-enhanced water-soluble organic PSs in SWIR window for self-reporting phototheranostics at ultra-high resolutions, providing an ideal solution for the next generation of photosensitizers for precise medicine.

 

 

118.      Ruohan Xu, Qifei Shen, Peijuan Zhang, Zhi Wang, Yanzi Xu, Lingjie Meng*, Dongfeng Dang*, Less is More: Asymmetric D–A Type Agent to Achieve Dynamic Self-Assembled Nanoaggregates for Long-Acting Photodynamic Therapy, Advanced Materials, 2024, 36, 28, 2402434

 

To enhance the phototheranostic performance, agents with high reactive oxygen species (ROS) generation, good tumor-targeting ability, and prolonged retention are urgently needed. However, symmetric donor–acceptor (D–A) type agents usually produce spherical nanoaggregates, leading to good tumor targeting but inferior retention. Rod-like nanoaggregates are desired to extend their retention in tumors; however, this remains a challenge. In particular, agents with dynamically changeable shapes that integrate merits of different morphologies are seldomly reported. Therefore, self-assembled organic nanoaggregates with smart shape tunability are designed here using an asymmetric D–A type TIBT. The photoluminescence quantum yield in solids is up to 52.24% for TIBT. TIBT also exhibits high ROS generation in corresponding nanoaggregates (TIBT-NCs). Moreover, dynamic self-assembly in shape changing from nanospheres to nanorods occurrs in TIBT-NCs, contributing to the enhancement of ROS quantum yield from 0.55 to 0.72. In addition, dynamic self-assembly can be observed for both in vitro and in vivo, conferring TIBT-NCs with strong tumor targeting and prolonged retention. Finally, efficient photodynamic therapy to inhibit tumor growth is achieved in TIBT-NCs, with an inhibition rate of 90%. This work demonstrates that asymmetric D–A type agents can play significant roles in forming self-assembled organic nanoaggregates, thus showing great potential in long-acting cancer therapy.

 

 

117.      Zhicheng Liu, Hao Zhang, Huining Su, Yang Chen, Xunan Jing, Daquan Wang, Shaohui Li, Hao Guan, Lingjie Meng*, Developing a multifunctional chitosan composite sponge for managing traumatic injuriest performance indicates they have potential role to play in trauma care, International Journal of Biological Macromolecules, 2024, 280, Part 4, 135895.

 

Developing porous hemostatic sponges that are both biosafe and multifunctional remains a complex challenge. Conventional hemostatic techniques often fall short in managing bleeding effectively, leading to severe critical cases such as suboptimal hemostasis, increased infection risk, and complications arising from profuse bleeding. To address these deficits, our study introduces a novel multifunctional nanocomposite sponge that synergistically incorporates chitosan (CS), cellulose (Cel), graphene oxide (GO), and silver (Ag) nanoparticles. The resulting CS/Cel/GO/Ag developed demonstrates a swelling rate exceeding 3000 %, an absorption rate of over 2100 %, and the lowest stress surpassing 20 kPa at an initial 80 % strain. In vitro analyses reveal that the CS/Cel/GO/Ag sponge has excellent cytocompatibility, non-hemolytic nature, and competence in blood cell adherence and bacterial inhibition. In vivo evaluations further demonstrate that compared to conventional hemostatic methods, the sponge substantially enhances hemostatic efficacy, as evidenced by the marked reductions in clotting times and diminished blood loss compared to conventional hemostatic methods. Specifically, the test results of the CS/Cel/GO/Ag sponge across three different models are as follows: for the rat tail amputation model, the clotting time was 99 s, while blood loss was 222 mg; for the rat liver injury model, the clotting time was 129 s. while blood loss was 812 mg; for the rat femoral artery laceration model, the clotting time was 96 s, while blood loss was 758 mg. The compelling attributes of the CS/Cel/GO/Ag sponges position them as a promising solution for the acute management of bleeding. Their excellent performance indicates they have potential role to play in trauma care.

 

 

116. Daquan Wang*, Xin Xu, Yao Qiu, Jiali Wang, Lingjie Meng*, Cyclotriphosphazene based materials: Structure, functionalization and applications, Progress In Materials Science, accepted, https://doi.org/10.1016/j.pmatsci.2024.101232. 

 

 

In recent decades, cyclotriphosphazene (CTP) and its derivatives have garnered significant attention due to their exceptional physical and chemical properties, such as remarkable thermal/radiation stability, chain flexibility, flame retardancy, biocompatibility, and biodegradability. Substantial progress has been made in CTP chemistry, as well as the exploration of new topological structures, functionalities, and applications of CTP-based materials. Thus, it holds great significance to summarize these key advancements to drive the development and application of CTP derivatives. In this comprehensive review, we present a historical perspective on the structures and properties of CTP and its derivatives. We provide an overview of the main chemical reactions and reaction mechanisms involved in CTP chemistry. Furthermore, we assess the current status of various CTP derivatives, including multi-substituted compounds, copolymers, linear polymers, dendrimers/hyperbranched polyphosphazenes, and crosslinked polyphosphazene, elucidating their synthesis methodologies. Moreover, we emphasize the recent notable achievements in a range of applications encompassing fluorescence, nonlinear optics, biomedical materials, catalyst supports, adsorption and separation, flame retardancy, and battery materials. Finally, we address the future opportunities and challenges associated with CTP derivatives.

 

2023年

 

115. Zhiqin Zhao, Anran Gao, Zhi Wang, Zhicheng Liu, Wenjing Xiong*, Yanzi Xu*, Lingjie Meng, Dongfeng Dang*, Recent advances of organic emitters in deep-red light-emitting electrochemical cells, 2023, online, https://doi.org/10.1002/bio.4657.

 

Light-emitting electrochemical cells (LECs) are kind of easily fabricated and low-cost light-emitting devices that can efficiently convert electric power to light energy. Compared with blue and green LECs, the performance of deep-red LECs is limited by the high non-radiative rate of emitters in long-wavelength region. While various organic emitters with deep-red emission have been developed to construct high-performance LECs, including polymers, metal complexes, and organic luminous molecules (OLMs), but this is seldom summarized. Therefore, we overview the recent advances of organic emitters with emission at the deep-red region for LECs, and specifically highlight the molecular design approach and electrochemiluminescence performance. We hope that this review can act as a reference for further research in designing high-performance deep-red LECs.

 

114. Xiaoping Zhao, Yang Chen, Ruoxin Niu, Ye Tang, Yanni Chen, Huining Su, Zhiwei Yang, Xunan Jing, Hao Guan*, Rui Gao*, Lingjie Meng*, NIR Plasmonic Nanozymes: Synergistic Enhancement Mechanism and Multi-Modal Anti-Infection Applications of MXene/MOFs, Advanced Materials, 2023, online, https://doi.org/10.1002/adma.202307839.

 

Nanozymes are considered as the promising antimicrobial agents due to the enzyme-like activity for chemo-dynamic therapy (CDT). However, it remains a challenge to develop novel nanozyme systems for achieving stimuli-responsive, and efficient nanozyme catalysis with multimodal synergistic enhancement. In this work, a near-infrared (NIR) plasmonic-enhanced nanozyme catalysis and photothermal performance for effective antimicrobial applications are proposed. A Ti3C2 MXene/Fe-MOFs composite (MXM) with NIR plasmonic-enhanced CDT combined with photothermal properties is successfully developed by loading metal-organic framework (MOF) nanozymes onto Ti3C2 MXene. The mechanism of NIR induced localized surface plasmon resonance (LSPR)-enhanced CDT and photothermal therapy (PTT) is well explained through activation energy (Ea), electrochemical impedance spectroscopy (EIS), X-ray photoelectron spectroscopy (XPS), fluorescence analysis experiments, and finite element simulation. It reveals that MXene nanosheets exhibit NIR plasmon exciters and generate hot electrons that can transfer to the surface of Fe-MOFs, promoting the Fenton reaction and enhances CDT. While the photothermal heating of MXene produced by LSPR can also boost the CDT of Fe-MOFs under NIR irradiation. Both in vitro and in vivo experimental results demonstrate that LSPR-induced MXM system has outstanding antimicrobial properties, can promote angiogenesis and collagen deposition, leading to the accelerated wound healing.

 

113. Huining Su, Yang Chen, Xunan Jing, Xiaoping Zhao, Heng Sun, Zhicheng Liu, Yao Qiu, Zuoliang Zhang, Hao Guan*, Lingjie Meng*, Antimicrobial, Antioxidant, and Anti-Inflammatory Nanoplatform for Effective Management of Infected Wounds, Advanced Healthcare Materials, 2023, online, https://doi.org/10.1002/adhm.202302868. (Frontispiece)

 

 

Burn wound healing continues to pose significant challenges due to excessive inflammation, the risk of infection, and impaired tissue regeneration. In this regard, an antibacterial, antioxidant, and anti-inflammatory nanocomposite (called HPA) that combines a nanosystem using hexachlorocyclotriphosphazene and the natural polyphenol of Phloretin with silver nanoparticles (AgNPs) is developed. HPA effectively disperses AgNPs to mitigate any toxicity caused by aggregation while also showing the pharmacological activities of Phloretin. During the initial stage of wound healing, HPA rapidly releases silver ions from its surface to suppress bacterial activity. Moreover, these nanoparticles are pH-sensitive and degrade efficiently in the acidic infection microenvironment, gradually releasing Phloretin. This sustained release of Phloretin helps scavenge overexpressed reactive oxygen species in the infected microenvironment area, thus reducing the upregulation of pro-inflammatory cytokines. The antibacterial activity, free radical clearance, and regulation of inflammatory factors of HPA through in vitro experiments are validated. Additionally, its effects using an infectious burn mouse model in vivo are evaluated. HPA is found to promote collagen deposition and epithelialization in the wound area. With its synergistic antibacterial, antioxidant, and anti-inflammatory activities, as well as favorable biocompatibilities, HPA shows great promise as a safe and effective multifunctional nanoplatform for burn injury wound dressings.

 

112. Qifei Shen, Kai Gao, Zhiqin Zhao, Anran Gao, Yanzi Xu, Heng Wang, Lingjie Meng, Mingming Zhang and Dongfeng Dang*, Aggregation-induced emission (AIE)-active metallacycles with near-infrared emission for photodynamic therapy, Chemical Communications, 2023,59, 14021-14024, https://doi.org/10.1039/D3CC04166B.

 

Multifunctional metallacycles with solid-state emission are highly important in cancer therapy. Here, an aggregation-induced emission (AIE)-active metallacycle of DTPABT-MC-R is developed with efficient emission in the NIR region in the solid state (PLQYs = 4.92%). DTPABT-MC-R-based nanoparticles also display excellent photo-stability, and impressive photosensitive characteristics (ROS efficiency = 10.74%), finally leading to applications in cellular imaging and photodynamic therapy (PDT).

 

111. Huining Su, Zhicheng Liu, Zuoliang Zhang, Xunan Jing, and Lingjie Meng*, Development of a Deep Eutectic Solvent-Assisted Kaempferol Hydrogel: A Promising Therapeutic Approach for Psoriasis-like Skin Inflammation, Molecular Pharmaceutics, 2023, 20, 12, 6319–6329, https://doi.org/10.1021/acs.molpharmaceut.3c00729.

 

 

Psoriasis is an incurable inflammatory skin disease that is mediated by the immune system. Although kaempferol has been known for its anti-inflammatory, antioxidant, and anticancer properties, its therapeutic effectiveness is often limited due to its poor water solubility and low bioavailability. To address these challenges, we developed a promising kaempferol hydrogel (DK-pGEL) using Pluronic F127 and a deep eutectic solvent (DES) with varying concentrations of kaempferol. In this study, we first evaluated the rheological properties and viscosity of the DK-pGEL hydrogel. The G′ of DK-pGEL (∼14 kPa) hydrogels was significantly lower than the control group (∼30 kPa) at 37 °C. The DK-pGEL hydrogel exhibited ideal fluidity and viscosity at 37 °C, as demonstrated by its shear-thinning behavior. Moreover, the DK-pGEL hydrogel showed controlled release characteristics with a drug release of 97.43 ± 5.37 μg/mL over 60 h. Furthermore, in vitro antioxidant experiments revealed that DK-pGEL exhibited significant radical scavenging ability against the DPPH-radical (96.27 ± 0.37%), ABTS-radical (98.11 ± 0.79%), hydroxyl-radical (66.36 ± 1.01%), and superoxide-radical (90.52 ± 0.79%) at a concentration of 250 μg/mL kaempferol. Additionally, DK-pGEL exhibited notable cellular antioxidant effects by inhibiting reactive oxygen species generation. Cell viability assays (CCK8) and live/dead cell assays were conducted to assess the cytotoxicity of DK-pGEL. The results showed that DK-pGEL could effectively inhibit HaCaT cell proliferation without causing significant cytotoxicity. To evaluate the therapeutic potential of DK-pGEL, an imiquimod (IMQ)-induced mouse model of psoriasis-like lesions was employed. Remarkably, the DK-pGEL hydrogel could significantly reduce the psoriasis area and severity index score, improve the histopathology induced by IMQ, and downregulate the expression of pro-inflammatory cytokines (TNF-α, IL-6, and IL-17A) in the skin tissue. These findings demonstrate that the DES-assisted kaempferol hydrogel holds promise as a topical drug delivery system for psoriasis treatment.

 

110. Qingmiao Zhang, Tianhao Yao, Qiangrui He, Heng Wang, Zhicheng Liu, Daquan Wang, Hongkang Wang, Lingjie Meng*, Enhancing lithium-ion storage performance of hollow CoS2/MoS2 nanospheres via N-doped carbon-coating, Journal of Energy Storage, 2023, 72(Part D), 108639, https://doi.org/10.1016/j.est.2023.108639.

 

Transition metal sulfides (TMSs) have been considered as up-and-coming anode materials for lithium-ion batteries (LIBs) owing to their large theoretical capacity and good reversibility. However, obvious volume variation and sluggish kinetics greatly limit their practical application. To address this issue, we successfully design and fabricate hollow CoS2/MoS2 nanospheres and effectively enhance their lithium storage performance via N-doped carbon-coating (CoS2/MoS2@N-C). The unique hollow structure provides shortened ion-diffusion path, while the N-doped carbon shells buffer the severe volume changes during cycling and improve the electronic conductivity of the electrode. When used as an anode material for LIBs, the CoS2/MoS2@N-C displays high specific capacity (1056.9 mA h g−1 at 100 mA g−1), excellent cycling stability (653.9 mA h g−1 after 250 cycles at 1000 mA g−1), and rate capability (685 mA h g−1 at 2000 mA g−1). The CoS2/MoS2@N-C||LiFePO4 full-cell LIB is also assembled and exhibits remarkable performance. The remarkable electrochemical performance of CoS2/MoS2@N-C electrode could be assigned to the synergistic enhancement effect of the N-doped carbon coating and hollow structure, which efficiently shorten the ion diffusion path, boost the charge transfer rate, and alleviated the volume changes of the electrode upon cycling.

 

109. Hong Zhang, Yuanfei Zhang, Yiyang Li, Min Hu*, Zihan Rong, Lingjie Meng, Xiaofei Zhang, Luan Wen, Xiumin Liang, Zhaopeng Chen, Chengcheng Liu*, A Novel Silver Nanoparticles-Decorated Metal-Organic Framework with Rapid and Sustained Antimicrobial Activity against Drug-Resistant Candida albicans through Synergistic Chemodynamic and Sonodynamic Therapy, Advanced Therapeutics, 2023, 6(8), 2300074,  https://doi.org/10.1002/adtp.202300074.

 

108.Tianhao Yao, Hongkang Wang, Xin Ji, Deyu Wang, Qingmiao Zhang, Lingjie Meng, Jian-Wen Shi, Xiaogang Han, Yonghong Cheng, Introducing Hybrid Defects of Silicon Doping and Oxygen Vacancies into MOF-Derived TiO2-X@Carbon Nanotablets Toward High-Performance Sodium-Ion Storage, Small,  2023, 19(38), 2302831,  https://doi.org/10.1002/smll.202302831.

 

107. Qingmiao Zhang, Tianhao Yao, Yanni Chen, Xunan Jing, Xiaoping Zhao, Daquan Wang, Hongkang Wang*, Lingjie Meng*, Polyphosphazene-derived P/S/N-doping and carbon-coating of yolk-shelled CoMoO4 nanospheres towards enhanced pseudocapacitive lithium storage, Journal of Colloid and Interface Science, 2023, 641, 366–375, https://doi.org/10.1016/j.jcis.2023.03.014.

Transition metal oxides as potential anodes of lithium-ion batteries (LIBs) possess high theoretical capacity but suffer from large volume expansion and poor conductivity. To overcome these drawbacks, we designed and fabricated polyphosphazene-coated yolk-shelled CoMoO4 nanospheres, in which polyphosphazene with abundant C/P/S/N species was readily converted into carbon shells and provided P/S/N dopants. This resulted in the formation of P/S/N co-doped carbon-coated yolk-shelled CoMoO4 nanospheres (PSN-C@CoMoO4). The PSN-C@CoMoO4 electrode exhibits superior cycle stability of 439.2 mA h g−1 at 1000 mA g−1 after 500 cycles and rate capability of 470.1 mA h g−1 at 2000 mA g−1. The electrochemical and structural analyses reveal that PSN-C@CoMoO4 with yolk-shell structure, coated with carbon and doped with heteroatom not only greatly enhances the charge transfer rate and reaction kinetics, but also efficiently buffers the volume variation upon lithiation/delithiation cycling. Importantly, the use of polyphosphazene as coating/doping agent can be a general strategy for developing advanced electrode materials.

 

106. Zhicheng Liu, Yanzi Xu, Huining Su, Xunan Jing, Daquan Wang, Shaohui Li, Yang Chen, Hao Guan, Lingjie Meng*, Chitosan-based hemostatic sponges as new generation hemostatic materials for uncontrolled bleeding emergency: Modification, composition, and applications, Carbohydrate Polymers, 2023, 311, 120780, https://doi.org/10.1016/j.carbpol.2023.120780.

The choice of hemostatic technique is a curial concern for surgery and as first-aid treatment in combat. To treat uncontrolled bleeding in complex wound environments, chitosan-based hemostatic sponges have attracted significant attention in recent years because of the excellent biocompatibility, degradability, hemostasis and antibacterial properties of chitosan and their unique sponge-like morphology for high fluid absorption rate and priority aggregation of blood cells/platelets to achieve rapid hemostasis. In this review, we provide a historical perspective on the use of chitosan hemostatic sponges as the new generation of hemostatic materials for uncontrolled bleeding emergencies in complex wounds. We summarize the modification of chitosan, review the current status of preparation protocols of chitosan sponges based on various composite systems, and highlight the recent achievements on the detailed breakdown of the existing chitosan sponges to present the relationship between their composition, physical properties, and hemostatic capacity. Finally, the future opportunities and challenges of chitosan hemostatic sponges are also proposed.

 

105. Xiaochen Su, Xunan Jing*, Wanting Jiang, Meng Li, Kai Liu, Menghao Teng, Daquan Wang, Lingjie Meng*, Yingang Zhang*, Wenchen Ji*, Curcumin-Containing polyphosphazene nanodrug for Anti-Inflammation and nerve regeneration to improve functional recovery after spinal cord injury, International Journal of Pharmaceutics, 2023, 642, 123197, https://doi.org/10.1016/j.ijpharm.2023.123197.

The microenvironment of excessive inflammation and the activation of apoptotic signals are primary barriers to neurological recovery following spinal cord injury (SCI). Thus, long-lasting anti-inflammation has become an effective strategy to navigate SCI. Herein, a curcumin (CUR)-containing nanosystem (FCTHPC) with high drug loading efficiency was reported via assembling hydrophobic CUR into cross-linked polyphosphazene (PPZ), and simultaneous loading and coordinating with porous bimetallic polymers for greatly enhanced the water-solubility and biocompatibility of CUR. The nanosystem is noncytotoxic when directing its biological activities. By inhibiting the expression of pro-inflammatory factors (IL-1β, TNF-α and IL-6) and apoptotic proteins (C-caspase-3 and Bax/Bcl-2), which may be accomplished by activating the Wnt/β-catenin pathway, the versatile FCTHPC can significantly alleviate the damage to tissues and cells caused by inflammation and apoptosis in the early stage of SCI. In addition, the long-term in vivo studies had demonstrated that FCTHPC could effectively inhibit the formation of glial scars, and simultaneously promote nerve regeneration and myelination, leading to significant recovery of spinal cord function. This study emphasises the promise of the biocompatible CUR-based nanosystem and provides a fresh approach to effectively treat SCI.

 

104. Xiaochen Su, Xunan Jing*, Wanting Jiang, Meng L, Kai Liu, Menghao Teng, Yayun Ma, Daquan Wang, Lingjie Meng*, Yingang Zhang*, Wenchen Ji*, Polyphosphazene Nanodrugs for Targeting Delivery and Inflammation Responsive Release of Curcumin to Treat Acute Lung Injury by Effectively Inhibiting Cytokine Storms, Colloids and Surfaces B: Biointerfaces, Available online, https://doi.org/10.1016/j.colsurfb.2023.113446.

An excessive inflammatory response induced by cytokine storms is the primary reason for the deterioration of patients with acute lung injury (ALI). Though natural polyphenols such as curcumin (CUR) have anti-inflammation activity for ALI treatment, they often have limited efficacy due to their poor solubility in water and oxidising tendency. This study investigates a highly cross-linked polyphosphazene nano-drug (PHCH) developed by copolymerisation of CUR and acid-sensitive units (4-hydroxy-benzoic acid (4-hydroxy-benzylidene)-hydrazide, D-HBD) with hexachlorotripolyphosphonitrile (HCCP) for improved treatment of ALI. PHCH can prolong the blood circulation time and targeted delivery into lung inflammation sites by enhancing CUR's water dispersion and anti-oxidant properties. PHCH also demonstrates the inflammation-responsive release of CUR in an inflammation environment due to the acid-responsive degradation of hydrazine bonds and triphosphonitrile rings in PHCH. Therefore, PHCH has a substantial anti-inflammation activity for ALI treatment by synergistically improving CUR's water-solubility, bioavailability and biocompatibility. As expected, PHCH attenuates the cytokine storm syndrome and alleviates inflammation in the infected cells and tissues by down-regulating several critical inflammatory cytokines (TNF-α, IL-1β, and IL-8). PHCH also decreases the expression of p-p65 and C-Caspase-1, inhibiting NLRP3 inflammasomes and suppressing NF-κB signalling pathways. The administrated mice experiments confirmed that PHCH accumulation was enhanced in lung tissue and showed the efficient scavenging ability of reactive oxygen species (ROS), effectively blocking the cytokine storm and alleviating inflammatory damage in ALI. This smart polyphosphazene nano-drug with targeting delivery property and inflammation-responsive release of curcumin has excellent potential for the clinical treatment of various inflammatory diseases, including ALI.

 

103. Zhao, Xiaoping; Yang, Zhiwei; Niu, Ruoxin; Tang, Ye; Wang, Heng; Gao, Rui; Zhao, Yizhen; Jing, Xunan; Wang, Daquan; Lin, Peng; Guan, Hao; Meng, Lingjie*, Analytical Chemistry (Washington, DC, United States) (2023), 95(2), 1731-1738 MIL-101(CuFe) nanozymes with excellent peroxidase-like activity for simple, accurate, and visual naked-eye detection of SARS-CoV-2, Anal. Chem., 2023, 95, 2, 1731 – 1738, https://doi.org/10.1021/acs.analchem.2c05043.

The COVID-19 pandemic has spread to every corner of the world and seriously affected our health and daily activities in the past three years; thereby, it is still urgent to develop various simple, quick, and accurate methods for early detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Nanozymes, a kind of nanomaterial with intrinsic enzyme-mimicking activity, have emerged as a suitable alternative for both therapy and diagnosis of SARS-CoV-2. Here, ultrasensitive and ultrafast MIL-101(CuFe)-CD147 biosensors are established for the detection of SARS-CoV-2 by a simple colorimetric method. A MIL-101(CuFe) metal-organic framework has excellent peroxidase-like activity due to the synergistic effect of Fe and Cu atoms. In addition, the MIL-101(CuFe)-CD147 biosensor shows great potential to detect the various variants of SARS-CoV-2 due to the universal receptor of CD147. The enzyme-based biosensor for the detection of SARS-CoV-2 achieves a very low limit of detection (about 3 PFU/mL) within 30 min. Therefore, the present method provides a new generation of an alternative approach for highly sensitive and visual diagnosis of COVID-19.

 

102. Daquan Wang, Huadong Zhao, Chao Deng, Wangrui Lei, Jun Ren, Shaofei Zhang, Wenwen Yang, Chenxi Lu, Ye Tian, Ying Chen, Yao Qiu, Lingjie Meng*, Yang Yang*,  Sulfide-modified nanoscale zero-valent iron as a novel therapeutic remedy for septic myocardial injury, Journal of Advanced Research, Available online, https://doi.org/10.1016/j.jare.2023.02.008.

     

Introduction: Myocardial injury is a serious complication in sepsis with high mortality. Zero-valent iron nanoparticles (nanoFe) displayed novel roles in cecal ligation and puncture (CLP)-induced septic mouse model. Nonetheless, its high reactivity makes it difficult for long-term storage.

Objectives: To overcome the obstacle and improve therapeutic efficiency, a surface passivation of nanoFe was designed using sodium sulfide.

 

101. Yanzi Xu, Peijuan Zhang, Anran Gao, Ruohan Xu, Zhi Wang, Qifei Shen, Zhiqin Zhao, Lingjie Meng, Dongfeng Dang,* Recent advances in activatable NIR-II organic fluorophores for biomedical applications, Materials Chemistry Frontiers, 2023, https://doi.org/10.1039/D2QM01120D.

                                                                                                              

Fluorescence imaging in the second near-infrared region (NIR-II) shows great potentials in intravital imaging and analysis due to its high penetration depth and low photo-damage. However, traditional organic fluorophores usually have inferior emission efficiency and exhibit “always on” signals in the NIR-II region. This leads to high background noise and then severely limits their further applications in vivo. Fortunately, activatable organic fluorescent probes can emit well only in response to some over-expressed specific biomarkers, thus resulting in high signal-to-background ratios (SBRs). At present, activatable organic fluorescent probes in the NIR-II region have gained considerable attention and make significant progress in the biomedical field. Therefore, in this review, we overview the molecular design and stimuli-responsive approach of these reported activatable NIR-II organic fluorophores. This is mainly classified by their various stimuli-responsive species, including redox species, enzymes, pH and also viscosity. Then, their applications in biomedical fields, ranging from biosensing to bioimaging and theranostic platforms, are also highlighted. Based on these results, it is anticipated that this review can help the development of activatable NIR-II organic fluorophores to be well understood, thus providing guidelines in their molecular design and synthesis. This review may also accelerate the further development of new activatable probes that can be used in real-world biomedical applications.

 

 

2022年

100. Peijuan Zhang, Qifei Shen, Yu Zhou, Fengyi He, Bo Zhao, Zhi Wang, Ruohan Xu, Yanzi Xu , Zhiwei Yang*, Lingjie Meng, Dongfeng Dang*, Synthesis of D-A typed AIE luminogens in isomeric architecture and their application in latent fingerprints imaging, Chinese Chemical Letters, 2023, 34(8), 107910, https://doi.org/10.1016/j.cclet.2022.107910.

Among the emitters in powder dusting to visualize the latent fingerprints (LFPs), aggregation-induced emission luminogens (AIEgens) are well employed for their high brightness and resistance to photo-bleaching. However, the serious background interference and low resolution still limit their fast development. Therefore, to further enhance the signal-to-noise ratio in LFPs imaging, especially to improve the analysis for level 3 details, donor-acceptor (D-A) typed AIEgens of DTPA-2,3-P, DTPA-2,5-P and DTPA-2,6-P are designed here. It is observed that strong emission covering from 450 nm to 650 nm can be obtained for all these molecules, especially that a high PLQY value of 10.06% in solids is achieved in DTPA-2,3-P. This is much higher than that of the other two cases (0.80% and 0.51%). By utilizing the DTPA-2,3-P in powder dusting, fluorescence imaging of LFPs can be clearly captured on both smooth and rough substrates. Moreover, confocal laser scanning microscope (CLSM) enables us to achieve high-resolution LFPs imaging in both 2D and 3D views, providing more detailed information of fingerprints pores in width, distance, distribution, and shapes. The results here demonstrate that highly emissive AIEgen of DTPA-2,3-P could be an excellent candidate for the visualization of fingerprints, thus providing the potential application in criminal investigation in the future.

 

99. Ruohan Xu, Weijie Chi, Yizhen Zhao, Ye Tang, Xunan Jing, Zhi Wang, Yu Zhou, Qifei Shen, Jun Zhang, Zhiwei Yang, Dongfeng Dang*, and Lingjie Meng*, All-in-One Theranostic Platforms: Deep-Red AIE Nanocrystals to Target Dual-Organelles for Efficient Photodynamic Therapy, ACS Nano, 2022, 16, 12, 20151–20162, https://doi.org/10.1021/acsnano.2c04465.

 

Aggregation-induced emission (AIE) nanoparticles have been widely applied in photodynamic therapy (PDT) over the past few years. However, amorphous nanoaggregates usually occur in their preparation, resulting in loose packing with disordered molecular structures. This still allows free intramolecular motions, thus leading to limited brightness and PDT efficiency. Herein, we report deep-red AIE nanocrystals (NCs) of DTPA-BS-F by following the facile method of nanoprecipitation. It is observed that DTPA-BS-F NCs possess not only a high photoluminescence quantum yield value of 8% in the deep-red region (600–850 nm) but also an impressive reactive oxygen species (ROS) generation efficiency of up to 69%. Moreover, DTPA-BS-F NCs targeting dual-organelles of lysosomes and nucleus to generate ROS are also achieved, thus boosting the PDT effect in cancer therapy both in vitro and in vivo. This work provides high-performance AIE NCs to simultaneously target two organelles for efficient photodynamic therapy, indicating their promising application in all-in-one theranostic platforms.

 

98. Ruohan Xu, Peijuan Zhang, Qifei Shen, Yu Zhou, Zhi Wang, Yanzi Xu, Lingjie Meng, Dongfeng Dang*, Ben Zhong Tang*, AIE nanocrystals: Emerging nanolights with ultra-high brightness for biological application, Coordination Chemistry Reviews, 2023, 477, 214944, https://doi.org/10.1016/j.ccr.2022.214944.

Aggregation-induced emission (AIE) dots and nanoparticles have been widely applied in biological research recently due to their high brightness, large Stokes' shift, good photo-stability and excellent biocompatibility. However, most AIE dots contain amorphous features. In these cases, although the intramolecular motions can be restricted to some degree, amorphous AIE nanoparticles still suffer from loose molecular packing, leading to the limited brightness. To solve this problem and further restrict intramolecular motion, nano-crystallization has been recently reported to produce highly emissive AIE nanocrystals (NCs), which display great potential for biological applications. Although there have been some reviews on AIE dots in recent years, research on AIE NCs has not been reviewed yet. Based on these considerations, the recent progress on AIE NCs, including their working mechanism, materials, preparation, characterization and also applications, have been summarized in this work, thus, providing a full picture and deep understanding of AIE NCs. This review also aims to offer guidelines to develop high-performance AIE NCs for material science and biological applications.

 

 

97. Xunan Jing, Lingjie Meng*, Shu Fan, Tingting Yang, Ning Zhang, Ruohan Xu, Xiaoping Zhao, Hongbo Yang, Zhiwei Yang, Daquan Wang, Yan Liang, Guoqing Zhou, Wenchen Ji*, Junjun She*, Tumor microenvironment self-regulation: Bimetallic metal  nanozyme-derived multifunctional nanodrug for optimizable cascade  catalytic reaction-synergetic anti-tumor theranostics, Chemical Engineering Journal, 2022, 442, 136096, https://doi.org/10.1016/j.cej.2022.136096.

The tumor microenvironment (TME) responsive multimodal theranostic nanoplatforms have attracted great attentions for precision medicine. To design well-defined cascade catalytic therapy and achieve the synergistic effect of different components in a nanoplatform, herein a spindle-shaped nanodrug termed as FeCu-GOx PNzyme-MTO was constructed by in-situ growth of bimetallic metal nanozyme (FeCu PNzyme), and simultaneous encapsulation of glucose oxidase (GOx) as well as fluorescent and chemotherapeutic mitoxanthrone (MTO). Interestingly, the obtained FeCu-GOx PNzyme is able to efficiently upregulate endogenous H2O2 level and down-regulate acidity via inducing the catalytic decomposition of intratumoral glucose to gluconic acid and H2O2 in TME, which is benefit to the cascade catalytic reactions for chemodynamic therapy (CDT). After efficient loading of MTO, such intelligent nanozyme triggers reactive oxygen species (ROS) generation in situ with tumor stimuli, self-augment ROS level upon intrinsic photothermal-conversion efficiency (53.05%) and glutathione (GSH) depletion, and specifically TME-responsive release of MTO to achieve high chemotherapeutic efficacy and biosafety. Both in vitro cellular assays and in vivo tumor-xenograft experiments proved that the tumor-specific cytotoxicity, biodegradability and potent antitumor efficiency of nanodrug, with co-contributions from highly cytotoxic ROS generated and precise drug delivery within tumors. This work thus presents the friendly construction of biocompatible FeCu-GOx PNzyme-MTO as effective nanodrug to provide a promising strategy for a new perspective on effective tumor therapy.

 

96. Daquan Wang, Changyu Wang, Zhenxing Liang, Wangrui Lei, Chao Deng, Xiaoli Liu, Shuai Jiang, Yanli Zhu, Shaofei Zhang, Wenwen Yang, Ying Chen, Yao Qiu, Lingjie Meng*, Yang Yang*, Protection of zero-valent iron nanoparticles against sepsis and septic heart failure, Journal of Nanobiotechnology, 2022, 20, 405, https://doi.org/10.1186/s12951-022-01589-1.

   

Background: Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero[1]valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe in septic cardiomyopathy remain unknown.

Results: NanoFe was prepared via the liquid-phase reduction method and functionalized with the biocompatible polymer sodium carboxymethylcellulose (CMC). We then successfully constructed a mouse model of septic myocardial injury by challenging with cercal ligation and puncture (CLP). Our findings demonstrated that nanoFe has a significant protective effect on CLP-induced septic myocardial injury. This may be achieved by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis.

Conclusions: The results provide a theoretical basis for the application strategy and combination of nanoFe in sepsis and septic myocardial injury.

 

95. Xunan Jing, Lingjie Meng*, Tingting Yang, Ning Zhang, Shu Fan, Yanni Chen, Hongbo Yang, Daquan Wang, Wenchen Ji*, Junjun She*, Biodegradable polyphosphazene-based nanodrug to regulate redox homeostasis for augmented chemo-photodynamic therapy, Dyes and Pigments, 2022, 199, 110095, https://doi.org/10.1016/j.dyepig.2022.110095.

Photodynamic therapy (PDT) is more precise than traditional tumor therapy. Nevertheless, PDT efficiency often is hindered by the antioxidant defense system which deplete the required reactive oxide species (ROS). Here we developed a simple but universal method by assembling anticancer drug (resveratrol, RV), photosensitizer (methylene blue, MB) and glutathione (GSH)-sensitive molecules (bis-(4-hydroxyphenyl)-disulfide, HPS) to covalent linking with hexachlorocyclotriphosphazene (HCCP) onto the Fe3O4 to construct a versatile drug delivery nanosystem (FHRHM). Notably, as a multifunctional nanodrug it shows good physiological stability, biocompatibility, and pH/GSH-responsive property to realize the RV and MB controlled release in tumor microenvironment (TME), maximum magnetic resonance (MR)/fluorescence (FL) imaging guided for synergistic chemo-photodynamic therapy (CT-PDT). Especially, the cross-linked FHRHM could be decomposed via reacting with high level of GSH to accelerate release MB for exogenous ROS generation, as well as disrupted disulfide bond (-S-S-) of HPS through depleting GSH to further reduce the endogenous ROS scavenging in TME, thus double amplifying the PDT and simultaneously enhancing CT to induce Hela cells death. This work highlights a novel strategy to construct TME-dissociable nanodrug for augmented CT-PDT via regulation of redox homeostasis, may provide a promising translational approach for tumor theranostics.

 

94. Xiaoping Zhao, Ruoxin Niu, Shu Fan, Xunan Jing, Rui Gao, Hongbo Yang, Heng Wang, Daquan Wang, Zhiwei Yang, Yunchuan Xie, Junjun She, Peng Chen,* and Lingjie Meng*, A Dual-Mode NADH Biosensor Based on Gold Nanostars Decorated CoFe2 Metal−Organic Frameworks to Reveal Dynamics of Cell Metabolism, ACS Sensors, Article ASAP, https://doi.org/10.1021/acssensors.2c01175.

                                                             

Nicotinamide adenine dinucleotide (NADH) is central to metabolism and implicated in various diseases. Herein, nanohybrids of gold nanostars and metal−organic frameworks are devised and demonstrated as a dual-mode NADH sensor, for which colorimetric detection is enabled by its peroxidase-like nanozyme property and Raman detection is realized by its surface-enhanced Raman scattering property with the detection limit as low as 28 pM. More importantly, this probe enables real-time SERS monitoring in living cells, providing a unique tool to investigate dynamic cellular processes involving NADH. Our experiments reveal that metabolism dynamics is accelerated by glucose and is much higher in cancerous cells. The SERS results can also be verified by the colorimetric detection. This sensor provides a new potential to detect biomarkers and their dynamics in situ.

 

93. Xiaoping Zhao, Tingting Yang, Daquan Wang, Ning Zhang, Hongbo Yang, Xunan Jing, Ruoxin Niu, Zhiwei Yang, Yunchuan Xie, and Lingjie Meng*, Gold Nanorods/Metal−Organic Framework Hybrids: Photo-Enhanced Peroxidase-Like Activity and SERS Performance for Organic Dyestuff Degradation and Detection, Anal. Chem. 2022, 94, 4484−4494, https://doi.org/10.1021/acs.analchem.2c00036.

Metal−organic frameworks (MOFs) are widely used to mimic enzymes for catalyzing chemical reactions; however, low enzyme activity limit their large-scale application. In this work, gold nanorods/metal−organic frameworks (Au NRs/FeMOF) hybrids were successfully synthesized for photo-enhanced peroxidase-like catalysis and surface-enhanced Raman spectroscopy (SERS). The enzyme-like activity of Au NRs/Fe-MOF hybrids was significantly enhanced under localized surface plasmon resonance (LSPR), because the hot electrons produced on Au NRs surface were transferred into Fe-MOF, activating the Fenton reaction by Fe3+/Fe2+ conversion and preventing the recombination of hot electrons and holes. This photo-enhanced enzyme-like catalytic performance was investigated by X-ray photoelectron spectrometry (XPS), electrochemical analysis, activation energy measurement, and in situ Raman spectroscopy. Afterward, Methylene Blue (MB) was chosen to demonstrate the photo-enhanced peroxidase-like performance of Au NRs/Fe-MOFs. The Au NRs/Fe-MOF caused chemical and electromagnetic enhancement of Raman signals and exhibited a great potential for the detection of toxic chemicals and biological molecules. The detection limit of MB concentration is 9.3 × 10⁻¹² M. In addition, the Au NRs/Fe-MOF hybrids also showed excellent stability and reproducibility for photo-enhanced peroxidase-like catalysis. These results show that nanohybrids have great potential in many fields, such as sensing, cancer therapy, and energy harvesting.

 

92. Xiaoping Zhao, Ning Zhang, Tingting Yang, Daomeng Liu, Xunan Jing, Daquan Wang, Zhiwei Yang, Yunchuan Xie, and Lingjie Meng*, Bimetallic Metal−Organic Frameworks: Enhanced Peroxidase-like Activities for the Self-Activated Cascade Reaction, ACS Applied Materials & Interfaces, 2021 13 (30), 36106-36116, https://doi.org/10.1021/acsami.1c05615.

Metal−organic frameworks (MOFs) are significant useful molecular materials as a result of their high surface area and flexible catalytic activities by tuning the metal centers and ligands. MOFs have attracted great attention as efficient nanozymes recently; however, it is still difficult to understand polymetallic MOFs for enzymatic catalysis because of their complicated structure and interactions. Herein, bimetallic NiFe2 MOF octahedra were well prepared and exhibited enhanced perox[1]idase-like activities. The synergistic effect of Fe and Ni atoms was systematically investigated by electrochemistry, X-ray photo[1]electron spectrometry, (XPS) and in situ Raman techniques. The electrons tend to transfer from Ni2+ to Fe3+ in NiFe2 MOFs, and the resulting Fe2+ is ready to decompose H2O2 and generate · OH by a Fenton-like reaction. After integration with glucose oxidase (GOx), which can downgrade the pH value and generate H2O2 by oxidation of glucose, a self-activated cascade reagent is therefore established for efficiently inducing cell death. The changes of cell morphology, DNA, and protein are also successfully recorded during the cell death process by Raman spectroscopy and fluorescence imaging.

 

91. Yanzi Xu, Dongfeng Dang*, Ning Zhang, Jianyu Zhang, Ruohan Xu, Zhi Wang, Yu Zhou, Haoke Zhang, Haixiang Liu, Zhiwei Yang, Lingjie Meng*, Jacky W. Y. Lam, and Ben Zhong Tang*, Aggregation-Induced Emission (AIE) in Super-resolution Imaging: Cationic AIE Luminogens (AIEgens) for Tunable Organelle-Specific Imaging and Dynamic Tracking in NanometerScale, ACS Nano, 2022, 16, 5932−5942, https://doi.org/10.1021/acsnano.1c11125.

                                                          

Organelle-specific imaging and dynamic tracking in ultrahigh resolution is essential for understanding their functions in biological research, but this remains a challenge. Therefore, a facile strategy by utilizing anion−π+ interactions is proposed here to construct an aggregation-induced emission luminogen (AIEgen) of DTPAP-P, not only restricting the intramolecular motions but also blocking their strong π−π interactions. DTPAP-P exhibits a high photoluminescence quantum yield (PLQY) of 35.04% in solids, favorable photo-stability and biocompatibility, indicating its potential applica[1]tion in super-resolution imaging (SRI) via stimulated emission depletion (STED) nanoscopy. It is also observed that this cationic DTPAP-P can specifically target to mitochondria or nucleus dependent on the cell status, resulting in tunable organelle-specific imaging in nanometer scale. In live cells, mitochondria-specific imaging and their dynamic monitoring (fission and fusion) can be obtained in ultrahigh resolution with a full-width-at-half-maximum (fwhm) value of only 165 nm by STED nanoscopy. This is about one-sixth of the fwhm value in confocal microscopy (1028 nm). However, a migration process occurs for fixed cells from mitochondria to nucleus under light activation (405 nm), leading to nucleus-targeted super-resolution imaging (fwhm= 184 nm). These findings indicate that tunable organelle-specific imaging and dynamic tracking by a single AIEgen at a superior resolution can be achieved in our case here via STED nanoscopy, thus providing an efficient method to further understand organelle’s functions and roles in biological research.

 

90. Daquan Wang*，Ning Zhang，Tingting Yang，Yun Zhang，Xunan Jing，Yu Zhou，Jiangang Long，Lingjie Meng*, Amino Acids and Doxorubicin as Building Blocks for Metal Ions-Driven Self-Assembly of Biodegradable Polyprodrugs for Tumor Theranostics, Acta Biomaterialia, 2022, 147, 245-257, https://doi.org/10.1016/j.actbio.2022.04.034.

 

On-demand designed theranostics nanoagents show promising applications for next-generation precision[1]and-personalized oncotherapy. Researchers have since aimed to develop nanoplatforms that can efficiently deliver drugs and contrast medium to tumor and release active ingredients in response to tumor microenvironment (TME) conditions. Herein, we propose a modular strategy, and develop a series of nanoplatforms based on metal-coordinated-polyprodrugs for cancer theranostics. The polyprodrugs were synthesized through a click-reaction between amino acid and doxorubicin (DOX) with dipropiolate. The backbones of the polyprodrugs had intrinsic sensitivities to pH and/or GSH, and provided abundant -COOH, -NH2, or -S-S- to chelate with functional metal ions and further self-assembled to form different morphologies. Dicysteine, which contains disulfide bond (-S-S-), was chosen to copolymerize with DOX and triethylene glycol dipropiolate (TEP) to prepare the pH/GSH dual-responsive polyprodrug poly(dicysteine-co-TEP-co-DOX) (pDTD), then separately coordinated with Gd3+, Fe3+, and Mn2+ to con[1]struct nanoplatforms pDTD@M (M representing the metal ions). In vitro and in vivo investigations suggest the metal-coordinated-polyprodrug nanoplatforms have good magnetic resonance imaging (MRI) ability and efficient tumor-growth inhibition with high safety. The design strategy of nanoplatforms based on metal-coordinated-polyprodrugs provides a new idea for on-demand construction of promising theranostics agents.

 

2021年

 

89. Zhi Wang, Yu Zhou, Ruohan Xu, Yanzi Xu, Dongfeng Dang*, Qifei Shen, Lingjie Meng, Ben Zhong Tang*, Seeing the unseen: AIE luminogens for super-resolution imaging, Coordination Chemistry Reviews, 2021, 451, 214279, https://doi.org/10.1016/j.ccr.2021.214279.

Super-resolution imaging (SRI) is of great significance to break the Abbe's diffraction limit, enabling visualization and dynamic monitoring with ultra-high resolution in both material science and biology. Fluorophores play an important role in SRI. Among them, aggregation-induced emission (AIE) luminogens (AIEgens) are one of the most promising imaging agents for SRI. They are easy to be synthesized and possess high tailoring ability, high brightness in aggregated states, large Stokes' shift, good photo-stability, and also excellent biocompatibility. Based on this consideration, the recent progress on AIEgens for SRI is summarized here. The working principles of AIEgens and several SRI techniques are also introduced to illustrate the material requirements. The new achievements in AIEgens research for SRI, including their chemical structures, optical properties, and applications, are highlighted in detail. The goal is to provide the readers with an overview of the recent advances in AIEgens for SRI. It is also anticipated that a deep understanding of the relationship between the AIEgens' properties and their imaging performance can be obtained. This review also aims to provide a set of guidelines to develop new AIEgens for fluorescence imaging to achieve superior resolution, thus resulting a better understanding of their mechanism in both biology and material science.

 

88. Ruohan Xu, Dongfeng Dang*, Zhi Wang, Yu Zhou, Yanzi Xu, Yizhen Zhao, Xiaochi Wang, Zhiwei Yang, Lingjie Meng*, Facilely prepared aggregation-induced emission (AIE) nanocrystals with deep-red emission for super-resolution imaging, Chemical Science, 2021,13, 1270-1280, https://doi.org/10.1039/D1SC04254H.

 

Organic nanocrystals (NCs) with high brightness are highly desirable for biological imaging. However, the preparation of NCs by a facile and fast method is still challenging. Herein, an aggregation-induced emission (AIE) luminogen of 4,4′-(5,6-difluorobenzo[c][1,2,5]thiadiazole-4,7-diyl)bis(N,N-bis(4-methoxyphenyl)aniline) (DTPA-BT-F) in the deep-red region is designed with intensive crystalline features to obtain NCs by kinetically controlled nanoprecipitation. The prepared AIE NCs with high brightness and good photo-stability are then applied in super-resolution imaging via stimulated emission depletion (STED) nanoscopy. As observed, the nanostructures in lysosomes of both fixed and live cells are well visualized with superior lateral resolutions under STED nanoscopy (full width at half maximum values, 107 and 108 nm) in contrast to that in confocal imaging (548 and 740 nm). More importantly, dynamic monitoring and long-term tracking of lysosomal movements in live HeLa cells, such as lysosomal contact, can also be carried out by using DTPA-BT-F NCs at a superior resolution. To the best of our knowledge, this is the first case of AIE NCs prepared by nanoprecipitation for STED nanoscopy, thus providing a new strategy to develop high performance imaging agents for super-resolution imaging.

 

 

87. Construction of hyperbranched and pH-responsive polymeric nanocarriers by yne-phenol click-reaction for tumor synergistic chemotherapy, Ning Zhang, Daquan Wang*, Tingting Yang, Xunan Jing, Lingjie Meng*, Colloids and Surfaces B: Biointerfaces, 2021, 204, 111790, https://doi.org/10.1016/j.colsurfb.2021.111790. 

                                                                

    In past decades, to improve the chemotherapeutic efficiency and reduce the systemic toxicity of small molecule anti-cancer drugs, polymer-based drug delivery systems (DDSs) have attracted great attention for tumor treatment due to their remarkable biocompatibility and responsive degradation in tumor microenvironment (TME). Herein, we developed a kind of pH-responsive and degradable hyperbranched polymeric nanocarriers via yne-phenol click-reaction of resveratrol (RSV) with bifunctional n-butyl dipropiolate (BDP) for efficient doxorubicin (DOX) delivery. The natural product RSV with three phenol groups has excellent antioxidant activity and synergetic enhancement for some anticancer drugs such as DOX. RSV tends to attack the alkynyl groups on BDP by nucleophilic addition in the presence of base as catalyst to afford hyperbranched polyprodrug (denoted as RB). PEGylated RB (termed as RBP) were further synthesized to improve the water solubility and prolong blood circulation by the click reaction of propiolate-terminated RB with amino terminated poly(ethylene glycol) (PEG-NH2). Interestingly, the RBP have high DOX loading ratio (∼58.6 %) at neutral pH, but the vinyl-ether bonds in RB could break down at low pH conditions such as acidic TME (extracellular pH∼6.8, endosomes and lysosomes pH∼5.0) that leading to the targeting release of DOX and RSV. Therefore, the developed RBP@DOX nanoparticles exhibited high kill efficiency to tumor cells and slight damage to normal cells due to the effective delivery and release of DOX and RSV in tumor sites and the synergistic enhancement effect of two drugs.

 

 

86. Boosting the AIEgen-based photo-theranostic platform by balancing radiative decay and non-radiative decay, Yanzi Xu, Dongfeng Dang*, Hongrui Zhu,  Xunan Jing, Xun Zhu, Ning Zhang,  Chunbin Li,  Yizhen Zhao,  Pengfei Zhang,  Zhiwei Yang*, Lingjie Meng*, Materials Chemistry Frontiers, 2021, Advance Article, https://doi.org/10.1039/D0QM01035A.

                                                                               

    It is noted that developing a single-molecule-triggered photo-theranostic platform for precise diagnosis and efficient cancer therapy is of great significance, but it still remains a difficult issue. In particular, it is challenging to balance the radiative decay (fluorescence) and non-radiative decay (photothermal effects) pathways for developed theranostic systems. Hence, the donor–acceptor–donor (D–A–D)-type aggregation-induced emission luminogen (AIEgen) of DTPA-BBTD is designed in this study. This molecule exhibits excellent absorption in the first near infrared (NIR-I) window as well as high brightness in the second near infrared (NIR-II) region, together with the favorable photoluminescence quantum yield (PLQY) of 1.51% compared with the commercial NIR-II fluorescent dye IR 26 used as a reference. In addition, owing to its efficient twisted intramolecular charge transfer effects and loose molecular packing when aggregated, DTPA-BBTD also exhibits an efficient photothermal conversion capability, thus providing the single-molecule-triggered photo-theranostic platform. It is observed that DTPA-BBTD-based AIE dots are successfully applied for NIR-II fluorescence imaging and NIR-I photoacoustic imaging to visualize the vasculature of mice and observe tumors in vivo, respectively. Moreover, photothermal therapy by using the developed AIE dots under irradiation is finally applied to well hinder tumor growth. This result demonstrates that manipulating the molecular backbone in AIEgens to balance the radiative decay and non-radiative decay can be an efficient strategy for constructing high-performance photo-theranostic platforms for precise cancer diagnosis and therapy.

 

85. Facile preparation of pH/redox dual-responsive biodegradable polyphosphazene prodrugs for effective cancer chemotherapy , Daquan Wang, Na Zhou, Ning Zhang, Zhe Zhi, Yongping Shao, Lingjie Meng*, Demei Yu*, Colloids and Surfaces B: Biointerfaces, 2021, 200, 111573, https://doi.org/10.1016/j.colsurfb.2021.111573.

                                       

    In order to maximize the therapeutic effect and and minimize the systemtic side effect of the small molecule anticancer drugs, biodegradable drug delivery systems (DDSs) that respond to tumor microenvironment (TME) have attracted significant attention. Herein, a novel redox/pH dual-responsive and biodegradable polyphosphazene (PPZ) nano-prodrugs have been prepared via one-pot crosslinking of vanillin modified DOX (VMD, acid-sensitive) and 4,4′-dihydroxydiphenyl disulfide (HPS, GSH-responsive) with hexachlorocyclotriphosphazene (HCCP). The phenol groups of the as-synthesized VMD and HPS have high nucleophilic substitution activity towards HCCP under base catalyst and afforded PPZ nano-prodrugs, denoted as HCCP-VMD-HPS, with a high drug loading ratio of up to 56.4 %. As expected, the skeleton of the PPZ consisting of imine bonds in VMD and the disulfide bonds in HPS and cyclotriphosphazenes inclined to be decomposed in low pH conditions and high level of GSH environments. The antitumor drug DOX was found to be controlled released in TME conditions (extracellular, pH∼6.8 and endosomes, lysosomes pH∼5.0 with ∼10 mM GSH), rather than neutral physiological conditions (pH 7.4 with ∼20 μM GSH). Moreover, the resulting HCCP-VMD-HPS nano-prodrug have obvious cytotoxicity to cancer cells while a negligible side effect to normal cells. We therefore believe that the prepared redox/pH dual-responsive and biodegradable PPZ DDSs have great potential in various field.

 

84.  Donor-Acceptor Typed AIE Luminogens with Near-infrared Emission for Super-resolution Imaging, Qifei Shen, Ruohan Xu, Zhi Wang, Tianyu Zhao, Yu Zhou, Yanzi Xu, Zhiwei Yang, Ming Lei,* Lingjie Meng & Dongfeng Dang*, Chemical Research in Chinese Universities, 2021, 37, 143-149, https://doi.org/10.1007/s40242-021-0390-5.

                                                                          

    Aggregation-induced emission(AIE) luminogens(AIEgens) with high brightness in aggregates exhibit great potentials in biological imaging, but these AIEgens are seldom applied in super-resolution biological imaging, especially in the imaging by using the structural illumination microscope(SIM). Based on this consideration, we synthesized the donor-acceptor typed AIEgen of DTPA-BTN, which not only owns high brightness in the near-infrared(NIR) emission region from 600 nm to 1000 nm(photoluminescence quantum yield, PLQYs=11.35%), but also displays excellent photo-stability. In addition, AIE nanoparticles based on 4,7-ditriphenylamine-[1,2,5]-thiadiazolo[3,4-c]pyridine(DTPA-BTN) were also prepared with highly emissive features and excellent biocompatibility. Finally, the developed DTPA-BTN-based AIE nanoparticles were applied in the super-resolution cellular imaging via SIM, where much smaller full width at half-maximum values and high signal to noise ratios were obtained, indicating the superior imaging resolution. The results here imply that highly emissive AIEgens or AIE nanoparticles can be promising imaging agents for super-resolution imaging via SIM.

 

83. An easily-synthesized AIE luminogen for lipid droplets-specific super-resolution imaging and two-photon imaging，Yanzi Xu, Haoke Zhang, Ning Zhang, Ruohan Xu, Zhi Wang,Yu Zhou,Qifei Shen, Dongfeng Dang,* Lingjie Meng,* Ben Zhong Tang.* Materials Chemistry Frontiers, 2021, 5, 1872-1883, https://doi.org/10.1039/D0QM00682C.

                                                  

     To obtain the lipid droplets (LDs)-specific super-resolution cellular imaging and deep-penetrated tissue imaging, an imaging platform of DTPA-BT-M with aggregation-induced emission (AIE) characteristics for stimulated emission depletion (STED) nanoscopy and two-photon fluorescence (TPF) microscopy is developed here. Benefiting from its excellent AIE properties, superior fluorescence properties in a deep-red region are observed for DTPA-BT-M with a high photoluminescence quantum yield of up to 33.96% in solid. In addition, DTPA-BT-M also exhibits large Stokes' shift, outstanding photostability, excellent biocompatibility and high LDs specificity. Furthermore, large two-photon absorption cross section of up to 1581 GM is also achieved in DTPA-BT-M since its symmetrical D-A-D architecture. Therefore, the developed AIE luminogen is simultaneously applied in STED nanoscopy and TPF microscopy, leading to an ultra-high resolution (full width at half-maximum value, FWHM= 95 nm) in DTPA-BT-M stained LDs via STED nanoscopy and also a much deep penetration of ~300 μm for lung tissue in BALB/C nude mice by TPF microscopy. The results here demonstrate that the easily-synthesized DTPA-BT-M can be an impressive imaging platform for LDs-specific super-resolution cells imaging and two-photon tissues imaging, thus providing the possibility to further understand LDs' roles in metabolic process in biological research.

 

82.  Recent advances in luminescent materials for super-resolution imaging via stimulated emission depletion nanoscopy，Yanzi Xu, Ruohan Xu, Zhi Wang, Yu Zhou, Qifei Shen, Wenchen Ji, Dongfeng Dang*, Lingjie Meng*, and Ben Zhong Tang*, Chemical Society Reviews, 2021,50, 667-690,  https://doi.org/10.1039/D0CS00676A.

                                                            

   Stimulated emission depletion (STED) nanoscopy is a promising fluorescence microscopy to detect unresolvable structures at the nanoscale level and then achieve a superior imaging resolution in material science and biological research. However, in addition to the optimization of microscope, luminescent materials in STED nanoscopy are also of great significance to obtain the imaging, visualization and even long-term tracking at an ultra-high resolution (less than 100 nm), but this is seldom summarized. Based on this consideration, recent progress on STED fluorophores for super-resolution imaging are outlined here, including inorganic fluorophores, fluorescent proteins, organic luminescent materials, aggregation-induced emission (AIE) luminogens, and fluorescent nanoparticles. The characteristics of these aforementioned STED fluorophores are also included and compared to provide a deep understanding of the relation between the properties in luminescent materials and their performance in STED imaging. According to the results on such luminescent materials, it is anticipated that guidelines to select proper probes and even develop new materials for super-resolution imaging via STED nanoscopy are provided here, finally promoting the development of super-resolution imaging in both material science and biological research.

 

2020年 

 

81.  Tuning Molecular Aggregation to Achieve Highly Bright AIE Dots for NIR-II Fluorescence Imaging and NIR-I Photoacoustic Imaging, Yanzi Xu, Chunbin Li, Ruohan Xu, Ning Zhang, Zhi Wang, Xunan Jing, Zhiwei Yang, Dongfeng Dang,* Pengfei Zhang* and Lingjie Meng*. Chemical Science, 2020, 11, 8157-8166

                                             

     

   Currently, bright aggregation-induced emission luminogens (AIEgens) with high photoluminescence quantum yields (PLQYs) in the NIR-II region are still limited, and thus an efficient strategy to enhance NIR-II fluorescence performance through tuning molecular aggregation is proposed here. The synthesized donor–acceptor tailored AIEgen (DTPA-TBZ) not only exhibits an excellent absorptivity in the NIR-I region, but also good fluorescence signals in the NIR-II region with an emission extending to 1200 nm. Benefiting from such improved intramolecular restriction and aggregation, a significant absolute PLQY value of 8.98% was obtained in solid DTPA-TBZ. Encouragingly, the resulting AIE dots also exhibit a high relative PLQY of up to 11.1% with IR 26 as the reference (PLQY = 0.5%). Finally, the AIE dots were applied in high performance NIR-II fluorescence imaging and NIR-I photoacoustic (PA) imaging: visualization of abdominal vessels, hind limb vasculature, and cerebral vessels with high signal to background ratios was performed via NIR-II imaging; Moreover, PA imaging has also been performed to clearly observe tumors in vivo. These results demonstrate that by finely tuning molecular aggregation in DTPA-TBZ, a good NIR-I absorptivity and a highly emissive fluorescence in the NIR-II region can be achieved simultaneously, finally resulting in a promising dual-modal imaging platform for real-world applications to achieve precise cancer diagnostics.

 

80.  One-pot synthesis of acid-degradable polyphosphazene prodrugs for efficient tumor chemotherapy, Na Zhou, Ning Zhang, Zhe Zhi, Xunan Jing , Daomeng Liu , Yongping Shao , Daquan Wang* and Lingjie Meng*，Journal of Materials Chemistry B, 2020,8, 10540-10548. (Inside Cover)

                                                                  

      In order to improve the therapeutic efficacy and reduce the side effects of anticancer drugs, stimuli-responsive and biodegradable drug-delivery systems have attracted significant attention in the past three decades. Herein, we report acid-responsive and degradable polyphosphazene nano-prodrugs synthesized via a one-pot cross-linking reaction of 4-hydroxybenzhydrazide-modified doxorubicin (BMD) with hexachlorocyclotriphosphazene (HCCP). The phenol groups in the as-synthesized BMD exhibited a high reactivity towards HCCP and in the presence of a basic catalyst the determined drug loading ratio of the nanoparticles, denoted as HCCP-BMD, was up to 85.64%. Interestingly, the hydrazone bonds in BMD and the skeleton of polyphosphazene tended to break down in acidic environments, and the antitumor active drug DOX was found to be released in an acidic tumor microenvironment (pH ∼ 6.8 for extracellular, and pH ∼ 5.0 for endosomes and lysosomes). The resulting HCCP-BMD prodrug exhibited high cytotoxicity to HeLa cells and could effectively suppress tumor growth, with negligible damage to normal tissues. We therefore believe that this acid- degradable polyphosphazene prodrug may offer great potential in various biomedical fields.

 

79.  Continuous phase regulation of MoSe 2 from 2H to 1T for the optimization of peroxidase-like catalysis，Daomeng Liu , Daquan Wang , Xunan Jing , Xiaoping Zhao , Duo Xi , Dongfeng Dang , Lingjie Meng*，Journal of Materials Chemistry B, 2020,8, 30, 6451-6458.

                                                

      Nanozymes are a new generation of artificial enzymes that address the limitations of natural enzymes, with numerous reports on the development of high performance nanozymes for various applications. Herein, the phase regulation of network-like MoSe2 from the metal 1T phase to semiconductor 2H phase was achieved under different reaction conditions by a facile but efficient microwave-assisted solvothermal method. The coexisting 1T/2H-MoSe2 with edge enriched and defective nanostructures showed great enhancement of the peroxidase-like properties. This high enzymatic activity may arise from optimized active sites of 1T/2H-MoSe2, effectively leading to a rapid charge transfer within the substrate. In addition, chitosan functionalization not only greatly improves the dispersion stability of MoSe2, but also significantly increases its peroxidase-like activity, probably due to its enhanced affinity to hydrogen peroxide (H2O2). Based on these results we have established a highly sensitive colorimetric assay for the detection of H2O2 and glucose in human serum.

 

 

78. Acid Responsive and Biologically Degradable Polyphosphazene Nanodrugs for Efficient Drug Delivery, Na Zhou,  Zhe Zhi, Daomeng Liu, Daquan Wang, Yongping Shao, Kai Yan, Lingjie Meng* and Demei Yu*, ACS Biomaterials Science & Engineering, 2020,  https://doi.org/10.1021/acsbiomaterials.0c00378

    

   To enhance the therapeutic effects and reduce damage to normal tissues in cancer chemotherapy, it is indispensable to develop drug delivery carriers with controllable release and well biocompatibility. In this work, an acid responsive and degradable polyphosphazene nanoparticles were synthesized by reaction of hexachlorotripolyphosphonitrile (HCCP) with 4-hydroxy-benzoic acid (4-hydroxy benzylidene) hydrazide (HBHBH) and anticancer drug doxorubicin (DOX)The controlled release of DOX could be realized based on the acid responsiveness of acylhydrazone in HBHBH. It was found that the resulting polyphosphazene nanoparticles remain stable in body's normal fluids (pH~7.4), while they were degraded and controllable release of DOX in acid environment such as tumors (pH~6.8), and lysosome and endosome (~5.0) in cancer cells. In particularly, the DOX loading ratio was fair high and could be tuned from 10.6% to 52.6% by changing the dosing ratio of DOX to HBHBH. Meanwhile, the polyphosphazene nanodrugs showed  excellent toxicity to tumor cells and reduced side effect to normal cells both in vitro and in vivo due to their enhanced  permeability and retention effect and pH sensitive degradation properties. Therefore, the constructed pH sensitive drug delivery system has great potential for cancer chemotherapy.

 

 77. Versatile Nanoplatforms with enhanced Photodynamic Therapy: Designs and Applications, Kai Yan, Yabin Zhang, Chenglong Mu, Qunna Xu, Xunan Jing, Daquan Wang, Dongfeng Dang, Lingjie Meng and Jianzhong Ma, Theranostics, 2020, in publishing.

 

 

    76. Cui Yuting, Li Yuan, Huang Na, Xiong Yue, Cao Ruijun, Meng Lingjie, Liu Jiankang*, Feng Zhihui*. Structure based  modification of chalcone analogue activates Nrf2 in the human retinal pigment epithelial cell line ARPE-19.Free Radical Biology and Medicine, 2020, 148(20): 52-59.

         Oxidative stress-induced degeneration of retinal pigment epithelial (RPE) cells is known to be a key contributor to the development of age-related macular degeneration (AMD). Activation of the nuclear factor-(erythroid-derived 2)-related factor-2 (Nrf2)-mediated cellular defense system is believed to be a valid therapeutic approach. In the present study, we designed and synthesized a novel chalcone analogue, 1-(2,3,4-trimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-acrylketone (Tak), as a Nrf2 activator. The potency of Tak was measured in RPE cells by the induction of the Nrf2-dependent antioxidant genes HO-1, NQO-1, GCLc, and GCLm, which were regulated through the Erk pathway. We also showed that Tak could protect RPE cells against oxidative stress-induced cell death and mitochondrial dysfunction. Furthermore, by modifying the α, β unsaturated carbonyl entity in Tak, we showed that the induction of antioxidant genes was abolished, indicating that this unique feature in Tak was responsible for the Nrf2 activation. These results suggest that Tak is a potential candidate for clinical application against AMD.

 

    75. Wang jinkai，Wang Hongkang*，Yao Tianhao，Liu Ting，Tian Yapeng, Li Chao, Li Fang, Meng Lingjie, Cheng Yonghong.Porous N-doped carbon nanoflakes supported hybridized SnO2/Co3O4 nanocomposites as high-performance anode for lithium-ion batteries. Journal of  Colloid and Interfaces Science. 2020,560:546-554

       Alloy-/conversion-type metal oxides usually exhibit high theoretical lithium storage capacities but suffer from the large volume change induced electrode pulverization and the poor electric conductivity, which limit their practical applications. Hybrid/mixed metal oxides with different working mechanisms/potentials can display advantageous synergistic enhancement effect if delicate structure engineering is performed. Herein, atomically hybridized SnO2/Co3O4 nanocomposites with amorphous nature are successfully cast onto the porous N-doped carbon (denoted as NC) nanoflakes through facile pyrolysis of the tin (II) 2-ethylhexanoate (C16H30O4Sn) and cobalt (II) 2-ethylhexanoate (C16H30O4Co) mixture within NC nanoflakes in air at 300 degrees C for 1 h. The Sn/Co atomic ratio and the loading amount of SnO2/Co3O4 can be readily controlled, whose effect on lithium storage are investigated as anodes for lithium ion batteries (LIBs). Notably, SnO2/Co3O4@NC (R-Sn/(Co) = 1.25) nanoflakes exhibit the most excellent lithium storage properties, delivering a reversible capacity of 1450.3 mA h g(-1) after 300 cycles at 200 mA g(-1), which is much higher than that of the single metal oxide SnO2@NC and Co3O4@NC electrodes.

 

    74. Duo Xi, Yanzi Xu, Ruohan Xu, Zhi Wang, Daomeng Liu, Qifei Shen, Ling Yue, Dongfeng Dang*, and Lingjie Meng*. A Facilely Synthesized Dual‐State Emission Platform for Picric Acid Detection and Latent Fingerprints Visualization. Chemistry, A Europen Journal, 2020, 26(12):2741-2748.

       To achieve a highly efficient dual‐state emission platform for picric acid (PA) detection and latent fingerprints (LFPs) visualization, flexible alkyl chains were facilely attached to the commercial organic dye, then providing target molecules of PTCA‐C4, PTCA‐C6, and PTCA‐C12. Interestingly, all these molecules exhibited impressive fluorescence characteristics with high photoluminescence quantum yields (PLQYs) of ~93.0% in dilute solution. Also, emissive features can be achieved in their solid state due to the prevented close molecular packing, especially for PTCA‐C6 with high PLQY value of 49.0%. Benefiting from its impressive fluorescence performance in both solution and aggregates, PTCA‐C6 was used as a dual‐state emission platform for PA detection and also LFPs visualization. Among them, a double‐responsive fluorescence quenching in solution was observed in the PA detection, resulting high quenching constant values ( Ksv ) and also low limit of detection values (LOD). On the other hand, PTCA‐C6‐based fingerprint powder also provided impressive performance on various substrates in terms of fluorescence intensity and resolution, thereby clearly providing the specific details in latent fingerprint. These results further demonstrated that this facilely synthesized PTCA‐C6 with efficient dual‐state emission exhibited great potentials in the real‐world applications of PA detection and latent fingerprint visualization.

 

     73. Yanzi XuHaoke ZhangNing ZhangXiaochi WangDongfeng Dang*Xunan JingDuo XiYing HaoBen Zhong Tang* and Lingjie Meng*. Deep-Red Fluorescent Organic Nanoparticles with High Brightness and Photostability for Super-Resolution in Vitro and in Vivo Imaging Using STED Nanoscopy. ACS Applied Materials & Interfaces. 2020,DOI: 10.1021/acsami.9b18336.

           

      To achieve super-resolution imaging in biological research using stimulated emission depletion (STED) nanoscopy, organic luminescent materials and their corresponding fluorescent nanoparticles with high brightness and photostability are of great significance. Herein, donor-acceptor-typed DBTBT-4C8 bearing flexible alkyl chains was developed, not only to afford deep-red emission from 600 to 800 nm but also to obtain high fluorescent brightness with the absolute photoluminescence quantum yields of 25%. After that, well-defined and monodispersed spherical nanoparticles using DBTBT-4C8 with bright emission, excellent biocompatibility, and photostability, which can easily mix with amphipathic block polymers, were then produced for super-resolution in vitro and in vivo imaging using STED nanoscopy. The observations showed that in contrast to confocal microscopy with a full width at half-maximum (FWHM) value of ≈400 nm, superior resolution with a significantly improved FWHM value of only 100 nm was achieved in biomedical cell imaging, which was also used to reconstruct three-dimensional images of stained HeLa cells at an ultrahigh resolution. More importantly, by using the prepared fluorescent organic nanoparticles (FONPs) in STED nanoscopy, in vivo imaging in glass catfish with largely enhanced resolution was also successfully achieved, demonstrating that these developed deep-red FONPs here are highly suitable for super-resolution in vitro and in vivo imaging using STED nanoscopy.

 

    72. Xunan Jing, Ning Zhang, Huanhuan Song, Yanzi Xu,Guoqing Zhou, Daquan Wang, Yongping Shao, Lingjie Meng*.  Multistage tumor microenvironment-responsive theranostic nanopeanuts: Toward multimode imaging guided chemo-photodynamic therapy. Chemical Engineering Journal. 2020,385,123893.

        

     It is of great importance to develop tumor microenvironment (TME) responsive and adjustable theranostic nano-systems for specific and efficient cancer treatment. However, carrier-based nanomedicines are often inefficacious in vivo due to low drug-loading efficiency, lack of synergistic effects, poor targeting specificity and limited drug accumulation in tumor tissues. Herein, we report a new multimodal theranostic nanoplatform which is assembled from Fe3O4 nanoclusters, MnO2 nanosheets with multifunctional and cross-linked polyphosphazene. This peanut-like nanoplatform exhibited enhanced chemo/photodynamic therapy (CT/PDT) effect as well as significant tumor-targeting capacity. In addition, Fe3O4cores and MnO2 nanoshells enables T1/T2 magnetic resonance imaging (MRI) of tumor tissues, while photosensitizer methylene blue (MB) allows for fluorescence imaging and PDT simultaneously. Importantly, nanopeanut agents could dual-regulate intracellular oxygen and glutathione (GSH) levels in TME by MnO2 shells, to relieve hypoxic condition and produce enough ROS to induce cell apoptosis. Our research demonstrated that the multistage TME-responsive nanoplatform is ideally suitable for tumor specific drug delivery and real-time disease tracking with enhanced theranostic properties.

 

2019年

 

71. Dongfeng Dang*, Haoke Zhang, Yanzi Xu, Ruohan Xu, Zhi Wang, Ryan T. K. , KwokJacky, W. Y. Lam, Lei Zhang, Lingjie Meng*, BenZhong Tang*. Super-Resolution Visualization of Self-Assembling Helical Fibers Using Aggregation-Induced Emission Luminogens in Stimulated Emission Depletion Nanoscopy. ACS Nano, 2019,13(10):11863-11873.

         Organic fluorophores for stimulated emission depletion (STED) nanoscopy usually suffer from quenched emission in the aggregate state and inferior photostability, which largely limit their application in real-time, in situ, and long-term imaging at an ultrahigh resolution. Herein, an aggregation-induced emission (AIE) luminogen of DP-TBT with bright emission in solid state (photoluminescence quantum yields = 25%) and excellent photostability was designed to meet the requirements in STED nanoscopy. In addition to its excellent fluorescence properties, DP-TBT could also easily form self-assembling helixes and finally be well-visualized by super-resolution STED nanoscopy. The observations showed that helical fibers of DP-TBT as dashed lines had a much decreased fiber width with also a full width at half-maximum value of only 178 nm, which is ∼6 times higher than solid lines obtained by confocal microscopy (1154 nm). The STED nanoscopic data were also used to reconstruct 3D images of assembled helixes. Finally, by long-term tracking and dynamic monitoring, the formation and growth of helical fibers by DP-TBT in self-assembly processes were successfully obtained. These findings imply that highly emissive AIEgens with good photostability are highly suitable for real-time, in situ, and dynamic imaging at super-resolution using STED nanoscopy.

 

70.Jianhui Li, Wei Wei*, Lingjie Meng*. Liquid-phase exfoliated-graphene-supporting nanostructural sulfur as high-performance lithium–sulfur batteries cathode. Composites Communications. 2019,15,149-154.

     Lithium-sulfur (Li–S) batteries with high energy density are promising candidates to satisfy emerging energystorage demands. Nevertheless, the poor conductivity of sulfur and fast capacity decay of the sulfur-based electrodes restrict its practical applications. Here, we report a facile and simple titration method to synthesize nano-sulfur@liquid-phase exfoliated graphene (Nano-S@LEGr) composites by in situ growth of nanostructural sulfur on the LEGr surface. The as-prepared Nano-S@LEGr with tunable sulfur morphologies exhibited excellent electrochemical performance as the cathode material for Li–S batteries. In particular, the spherical Nano-S@LEGr composites with 68 wt% sulfur displayed a reversible capacity of 552.8 mAh g−1 after 100 cycles at a current density of 0.5C. Even at a high current density of 1C, a discharge capacity of 532.8 mAh g−1 could be delivered. Compared to rod-like Nano-S@LEGr and the graphene oxide derived cathode, the as-prepared spherical Nano-S@LEGr showed higher specific capacity, superior cycling stability and rate capability.

 

69.Xunan Jing, Yanzi Xu, Daomeng Liu,Youshen Wu,Na Zhou, Daquan Wang,Kai Yan  and  Lingjie Meng*. Intelligent nanoflowers: a full tumor microenvironment-responsive multimodal cancer theranostic nanoplatform.Nanoscale, 2019,11(33):15508-15518.

      Although the collaborative therapy of chemotherapy (CT) and photodynamic therapy (PDT) is much more efficient for tumor treatment than monotherapies, premature leakage of drugs from nanocarriers and hypoxia in the tumor microenvironment (TME) result in systemic toxicity and suboptimal therapy efficiency. To overcome these limitations, we developed an intelligent nanoflower composite (termed FHCPC@MnO2) by coating functionalized polyphosphazene on superparamagnetic Fe3O4 nanoclusters and then growing MnO2 nanosheets as an outer shell. The FHCPC@MnO2 nanoflowers with multistage H2O2/pH/GSH-responsive properties could fully exploit TME characteristics, including supernormal glutathione (GSH) levels, low pH and high H2O2, to realize the specific release of drugs in tumors and maximum synergetic therapeutic effects. The MnO2 nanosheets can elevate O2 concentration by catalytic decomposition of H2O2 and can be simultaneously reduced to Mn2+ by overexpressed GSH in the acidic TME. Meanwhile, the inner polyphosphazene containing (bis-(4-hydroxyphenyl)-disulfide) is GSH- and pH-sensitively biodegradable to release the anticancer drug curcumin (CUR) and photosensitizer chlorin e6 (Ce6) in the TME. Therefore, the “triple-responsive” and synergetic strategy simultaneously endows the nanoflowers with specific drug release, relieving hypoxia and the antioxidant capability of the tumor and achieving significant optimization of CT and PDT. In addition, the resulting Mn2+ ions and Fe3O4 core enable in vivo T1/T2 magnetic resonance imaging (MRI), while the released Ce6 can simultaneously provide a fluorescence imaging (FL) function. Unsurprisingly, the intelligent nanoflowers exhibited remarkable multimodal theranostic performance both in vitro and in vivo, suggesting their great potential for precision medicine.

 

68.Fei Wang, Jing Liu,Daquan Wang,Zhiwei Yang, Kai Yan and  Lingjie Meng*. One-step synthesis of cross-linked and hollow microporous organic-inorganic hybrid nanoreactors for selective redox reactions .Nanoscale, 2019,11(33):15017-15022. 

      Hollow microporous nanostructures (HMNs) are powerful platforms for multiple promising applications, including energy storage, drug/gene delivery, nanoreactors/catalysis, adsorption, and separation. Herein, we report a facile one-step method to synthesize highly cross-linked organic–inorganic hybrid poly(cyclotriphosphazene-co-4,4′-sulfonyldiphenol) (PZS) HMNs via a salt-induced liquid–liquid separation process. The size of inner cavities can be properly tuned by modulating the concentration of the NaOH solution. The regulation mechanism of the PZS HMNs was further confirmed by encapsulating water-dispersed Pt nanoclusters into the cavities. Interestingly, the resulting yolk–shell Pt@PZS serves as nanoreactors and exhibits excellent substrate selectivity and recyclability for the catalytic oxidation of 1,3,5-trimethylbenzene.

 

67.Zhiwei Yang, Yizhen Zhao, Dongxiao Hao, Shunlin Ren, Xiaohui Yuan, Lingjie Meng, Shengli Zhang.Bindings of PPARγ ligand-binding domain with 5-cholesten-3β, 25-diol, 3-sulfate: accurate prediction by molecular simulation.Journal of Biomolecular Structure and Dynamics. 2019,doi.org/10.1080/07391102.2019.1577175.

             Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been identified as an attractive target for atherosclerosis intervention. Given potential relevance of 5-cholesten-3β, 25-diol, 3-sulphate (CHOS) and PPARγ, an integrated docking method was used to study their interaction mechanisms, with the full considerations to distinct CHOS conformations and dynamic ensembles of PPARγligand-binding domain (PPARγ-LBD). The results revealed that this novel platform is satisfactory to the accurate determination of binding profiles, and the binding pattern of CHOS is rather similar as those of current PPARγ full/partial agonists. CHOS contributes to the stabilization of the AF2 and β-sheet surfaces of PPARγ-LBD and promotes the configuration adjustment of Ω loop, in order to inhibit the Cdk5-mediated PPARγ phosphorylation. Nonetheless, there are clear differences in term of occupation of full or partial agonist-like binding models. The energetic and geometric analyses further revealed that CHOS may be fond of partial agonist-like binding, and its sulfonic group and carbon skeleton are helpful for the binding process. We hope that the results will aid our understanding of recognitions involving CHOS with PPARγ-LBD and warrant the further aspects to pharmacological experiments.

 

66.Jianhui Li, Shaobo Han, Chgenyu Zhang, Wei Wei*, Meng Gu*, Lingjie Meng*. High-Performance and Reactivation Characteristics of High-Quality, Graphene-Supported SnS2 Heterojunctions for a Lithium-Ion Battery Anode. ACS Applied Materials & Interfaces 2019, 11, 22314-22322.(IF=8.097)

      SnS2 has received tremendous attention as an anode material for lithium-ion batteries owing to its high theoretical capacity and low cost. However, its applications are limited by its inferior cycling stability and poor rate performance. In this study, graphene@SnS2 heterojunction nanocomposites are synthesized using a microwave-assisted solvothermal approach on liquid-phase exfoliated graphene (LEGr). Compared with graphene oxides, LEGr layers with an intrinsic atomic structure show extraordinary conductivity and serve as robust substrates for in situ growth of SnS2 with improved interfacial contact. A LEGr-derived SnS2 hybrid shows remarkable storage capacity, superior rate capability, and excellent cycling stability. The storage capacity remains at 664 mAh g–1 after 200 cycles at 300 mA g–1 current density. Furthermore, lithiation-induced reactivation of LEGr-based SnS2 is investigated using in situ transmission electron microscopy, giving an in-depth explanation of the electrochemical reaction mechanisms.

 

65.Xunan Jing, Zhe Zhi, Liming Jin, Fei Wang, Youshen Wu, Daquan Wang, Kai Yan, Yongping Shao and Lingjie Meng*.  pH/redox dual-stimuli-responsive cross-linked polyphosphazene nanoparticles for multimodal imaging-guided chemo-photodynamic therapy. Nanoscale. 2019, 19(11):9457-9467 .(IF=7.233)

          Multifunctional nanodrugs with the integration of precise diagnostic and effective therapeutic functions have shown great promise in improving the efficacy of cancer therapy. We report herein a simple and effective approach to directly assemble an anticancer drug (curcumin), a photodynamic agent (Ce6) and tumor environment-sensitive molecules into cross-linked polyphosphazene and coat on superparamagnetic Fe3O4 nanoclusters to form discrete nanoparticles (termed as FHCPCe NPs). FHCPCe NPs have high physiological stability and good biocompatibility, and can enhance accumulation in tumor tissue via the enhanced permeability and retention effect. Meanwhile, the FHCPCe NPs exhibit an effective performance of dual-modality magnetic resonance imaging (MRI) due to the Fe3O4 cores and fluorescence imaging (FL) in the xenografted HeLa tumor because of the fluorescence of Ce6. Importantly, under the conditions of supernormal glutathione levels and acidic microenvironment in tumor tissue, curcumin and Ce6 can be effectively released by the degradation of FHCPCe NPs. Therefore, excellent anti-tumor effects both in vitro and in vivo have been achieved by synergistic chemotherapy/photodynamic therapy (CT/PDT) using multifunctional NPs. Our study highlights the promise of developing multifunctional nanomaterials for accurate multimodal imaging-guided highly sensitive therapy of cancer.

 

64.Jianhui Li, Hongkang Wang, Wei Wei*, Lingjie Meng*. Advanced MoS₂ and graphene heterostructures as high-performance anode for sodium-ion batteries. Nanotechnology. 2019, 30(10):104003.(IF=3.404)

 

           Layer-structured MoS2 is a promising anode material for sodium-ion batteries (SIBs) because of its high storage capacity, abundance in nature, and cost-effectiveness. However, the use of MoS2 is limited by its low electronic conductivity, inferior cycling stability, and poor rate capability. To overcome these drawbacks, liquid-phase exfoliated graphene (LEGr) was used as the support, for which MoS2@LEGr heterostructures with a tunable loading amount of MoS2 were fabricated by a microwave-assisted solvothermal method. LEGr with its exceptional atomic structure not only serves as a robust structural support of MoS2 but also provides rapid electrical and ionic transfer pathways of the electrode material. When MoS2@LEGr heterostructures were applied for SIB anodes, the heterostructures exhibited a considerably enhanced sodium storage performance compared to pure MoS2, including higher sodium storage capacity as well as superior cycling stability and rate capability.

 

2018年

 

63.Jianhui Li, Haiting Yan, Wei Wei, Lingjie Meng*.  Microwave-assisted mass synthesis of Mo1−xWxS2 alloy composites with a tunable lithium storage property. Dalton Transction. 2018, p1-3.(IF=4.099)

 

62. Jianhui Li, Haiting Yan, Wei Wei, Lingjie Meng*.  Salt and water co-assisted exfoliation of graphite in organic solvent for efficient and large scale production of high-quality graphene. Journal of Colloid and Interface Science, 2018, P92-99. (IF=5.091)

 

     

      Graphene has attracted enormous attention due to its unique physical properties and attractive applications in many fields. However, it is an ongoing challenge to develop a facile and low-cost method for the large scale preparation of high-quality graphene (HQGr). In this work, we have developed an improved liquid-phase exfoliation method to mass produce HQGr. This method is quite simple but efficient by exfoliation of graphite in organic solvent with the co-assistance of sodium citrate and water. Remarkably, the concentration of as-exfoliated HQGr was as high as 0.71 mg/mL under optimal conditions, while the oxygen content in HQGr was only 2.39%. After annealing at 500 °C for 2 h in argon atmosphere, the mean conductivity of annealed HQGr was as high as 1.4 × 104 S m−1. Therefore, this facile method for liquid-phase exfoliation of graphite has excellent potential in the industrial-scale production of HQGr for numerous applications in energy storage, optical and electronic fields.

 

61. Jing Liu, Lingjie Meng*, Zhaofu Fei*, Paul J Dyson, Lei Zhang. On the origin of the synergy between the Pt nanoparticles and MnO2 nanosheets in Wonton-like 3D nanozyme oxidase mimics. Biosensor & Bioelectronics. 2018., p159-165. (IF=8.173)

           We describe a 3-dimensional scaffold nanocomposite oxidase nanozyme (termed PtNPs@MnO2) formed from 2-dimensional MnO2 nanosheets grown on the surface of large platinum nanoparticles (PtNPs). The two components act synergistically in the catalytic oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB), due to the intimate contact between the two components and mutual electron transfer phenomena. The Wonton-like 3-dimensional structure of the nanocomposite is highly stable and was characterized by cryogenic electron microscopy (cryo-EM). The PtNPs@MnO2 nanocomposite was employed in a sensing assay for the determination of glutathione (GSH) and dopamine (DA) with a linear range of 0.2 μM − 11 μM for GSH and 0.1 μM − 1.1 μM for DA. The limit of detection (LOD) and limit of quantification (LOQ) of GSH are 0.05 μM (S/N=3) and 0.17 μM (S/N=10), respectively. The LOD and LOQ for DA were estimated as 0.025 μM and 0.083 μM. The method was applied to analyze GSH in human serum samples and DA in pharmaceuticals.

 

60. Jianhui Li, Haiting Yan, Wei Wei*, Xifei Li, Lingjie Meng*. Enhanced Lithium Storage Performance of Liquid‐Phase Exfoliated Graphene Supported WS₂ Heterojunctions. ChemEletroChem,2018,https://doi.org/10.1002/ celc.201800926.(IF=4.446)

 

       To improve the electrical conductivity and the cycling stability of layered transition metal disulfides (TMDs) as lithium‐ion battery anode, graphene@WS2 heterojunction composites are prepared by a facile one‐pot process, involving liquid‐phase exfoliation of graphene in N‐methylpyrrolidone, followed by in‐situ growth of WS2 in the graphene dispersion induced by a microwave‐assisted solvothermal method. The liquid‐phase exfoliated graphene (LEGr) with exceptional atomic structure not only serves as a substrate to couple WS2, but also serves as a mini‐current collector for the rapid transport of electrons within the anode. The LEGr‐based heterojunction WS2 composites exhibit improved lithium storage performance compared to the counterpart based on graphene oxide (GO), including higher lithium storage capacity, superior rate capability and outstanding cycling stability. This protocol enables processing and construction of advanced TMD heterojunction electrodes based on LEGr using an economical pathway.

 

59.  Yanzi Xu, Lin Ren, Dongfeng Dang*, Ying Zhi, Xiaochi Wang, Lingjie Meng*. A Strategy of "Self‐Isolated Enhanced Emission" to Achieve Highly Emissive Dual‐State Emission for Organic Luminescent Materials.Chem. Eur. J. 2018, https://doi.org/ 10.1002/chem.201802201. (IF=5.317)

         Currently, the commonly developed organic luminescent materials (OLMs) usually exhibit poor luminescent performance in aggregated solid states compared with their well‐dissolved solution states, making it a tough goal to achieve the highly emissive dual‐state emission. To overcome this limitation, "Self‐Isolated Enhanced Emission" (SIEE) strategy through flexible alkyl chains to suppress the emission‐quenched π‐π stacking in solids is proposed here and based on this guideline, remarkable emission efficiency with photoluminescence quantum yields up to 99.72% in solution and 77.46% in solid state are finally achieved for the SIEE constructed DBBT‐C8, which is then successfully used in the solid state display and data encryption.

 

58. Dongfeng Dang, Xiaochi Wang, Daquan Wang, Zhiwei Yang, Dongxiao Hao, Yanzi Xu, Shengli Zhang, and Lingjie Meng*.  Fluorescent Organic Nanoparticles Constructed by a Facile “Self-Isolation Enhanced Emission” Strategy for Cell Imaging. ACS Appl. Nano Mater., 2018, 1 (5), pp 2324–2331

    To achieve the highly emissive features and overcome the troublesome photobleaching for fluorescent organic molecules, a facile and versatile strategy named “self-isolation enhanced emission (SIEE)” was developed to prevent the π–π stacking of organic fluorophores by linking alkyl chains on their conjugated backbones. As a proof-of-concept, one or two octyl groups were grafted onto the backbone of 4,7-di(thiophen-2-yl)benzo[c][1,2,5]thiadiazole (termed as DTBT-0), resulting in two different molecules, termed as DTBT-1 and DTBT-2, respectively. Compared with DTBT-0, DTBT-1 and DTBT-2 exhibited remarkably enhanced fluorescent properties in both aggregated thin films and nanoparticles, demonstrating that the SIEE method could isolate the fluorophores effectively and then prevent their π–π stacking to achieve the impressive fluorescent properties. After proper surface modification, excellent water dispersibility, biocompatibility, and improved resistance to photobleaching were also achieved for highly emissive DTBT-2-based nanoparticles, which were then successfully applied for cellular imaging.

 

57. Daquan Wang, Lingjie Meng*, Zhaofu Fei, Chen Hou, Jiangang Long, Leli Zeng, Paul J. Dyson and Peng Huang. Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity.  Nanoscale, 2018,10, 8536-8546 . (IF=7.233)

     Multi-layered single-walled carbon nanotubes, termed SWNT@BSA@Au-S-PEG-FA@DOX, which integrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process. Oxidized and cut single-walled carbon nanotubes (SWNTs) were coated with bovine serum albumin (BSA) to provide abundant active sites for the nucleation of Au seeds, which are subsequently converted into gold nanoparticles (Au NPs) by in situ reduction. The resulting SWNT@BSA@Au material exhibits ideal photothermal properties. Further modification of the nanomaterial with folic acid terminated-polyglycol (FA-PEG-SH) and subsequent loading with doxorubicin (DOX) afford the SWNT@BSA@Au-S-PEG-FA@DOX. The FA terminated PEG endows the material with high water-dispersibility, biocompatibility and cancer cell selectivity. A high drug loading ratio for DOX of up to 590% was achieved, with the drug release being pH and temperature dependent, adding to the selectivity of the system. High efficacy of the SWNT@BSA@Au-S-PEG-FA@DOX material, when combined with photothermal therapy (irradiation of the tumor with an 808 nm laser, 1 W cm−2 for 5 min, 24 h after systemic injection of the nanomedicine), was demonstrated in vivo, resulting in complete tumor eradication. Remarkably, the side effects are negligible with only minor damage to normal tissues including the liver and kidneys being observed. 

 

56. Zhi, Ying ; Zhao, Baofeng ; Cao, Ruijun; Xu, Yanzi ; Wang, Jianguo; Dang, Dongfeng* ; Gao, Chao; Meng, Lingjie*. Triphenylamine cored electron-donors for solution-processed organic solar cells: From tri-armed molecules to tetra-armed molecules.DYES AND PIGMENTS, 153: 291-299. (IF=3.767)

 

 

     A novel tetra-armed D-A type small molecule 4BTF-DTPA-T was designed here by utilizing the thiophene connected ditriphenylamine (DTPA) core and fluorinated benzothiadiazole (BTF) arms. To make a better comparison, tri-armed (star-shaped) 3BTF-TPA was also synthesized. Although a similar absorption spectra covering from 300 to 600 nm was observed for 3BTF-TPA and 4BTF-DTPA-T, much higher extinction coefficient was achieved for tetra-armed 4BTF-DTPA-T in both solution and thin films. Bulk hetero-junction (BHJ) organic solar cells were also fabricated to investigate their photovoltaic performance and as anticipated, a moderate PCE value of 2.61% with a V-oc of 1.00 eV was observed in 3BTF-TPA-based solar cells. However, when the tetra-armed 4BTF-DTPA-T was employed as the electron-donors, much enhanced J(EC) and FF values up to 9.33 mA/cm(2) and 44.80% were achieved for its homogeneous morphology in solar cells, finally leading to the maximum PCE value of 3.68%, indicating that the tetra-armed small molecules could be the promising electron-donors for solution processed organic solar cells.

 

55. Haiting Yan, Jianhui Li, Daomeng Liu, Xunan Jing, Daquan Wang and Lingjie Meng*. Controlled preparation of high quality WS2nanostructures by a microwave-assisted solvothermal method. CrystEngComm, 2018,20, 2324-2330. (IF=3.304)

     Thin-layered WS2 nanostructures have attracted great attention owing to their superior structures and properties when compared to MoS2, including larger layer-spacing, higher energy gap and better photothermal and lubrication properties. However, it is still challenging to prepare high-quality WS2 nanosheets and assemble them into large quantities. In this work, we report a facile and efficient microwave-assisted solvothermal method for the synthesis of WS2 nanostructures in N-methyl-2-pyrrolidone (NMP) using cheap tungsten hexachloride (WCl6) and elemental sulfur (S) as starting materials. The formation of WS2 nanosheets and their controlled assembly into different morphologies (such as nanocones and nanoworms) were studied by adjusting the reactant concentration and reaction temperature. This method has also been successfully applied for preparation of other transition-metal dichalcogenides such as MoS2. The resulting WS2 and MoS2 nanomaterials were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The photothermal properties of WS2nanostructures have been investigated and it was found that the WS2 nanosheets have the best photothermal efficiency and stable photothermal capacity, exhibiting great potential for photothermal therapy and other fields.

 

54. Xunan Jing, Zhe Zhi, Daquan Wang, Jing Liu, Yongping Shao, and Lingjie Meng* .Multifunctional Nanoflowers for Simultaneous Multimodal Imaging and High-Sensitivity Chemo-Photothermal Treatment.Bioconjugate Chem., 2018, 29 (2), pp 559–570.  (IF=4.485)

     Liver cancer is currently among the most challenging cancers to diagnose and treat. It is of prime importance to minimize the side effects on healthy tissues and reduce drug resistance for precise diagnoses and effective treatment of liver cancer. Herein, we report a facile but high-yield approach to fabricate a multifunctional nanomaterial through the loading of chitosan and metformin on Mn-doped Fe3O4@MoS2 nanoflowers. Mn-doped Fe3O4 cores are used as simultaneous T1/T2 magnetic resonance imaging (MRI) agents for sensitive and accurate cancer diagnosis, while MoS2 nanosheets are used as effective near-infrared photothermal conversion agents for potential photothermal therapy. The surface-functionalized chitosan was able not only to improve the dispersibility of Mn-doped Fe3O4@MoS2 nanoflowers in biofluids and increase their biocompatibility, but also to significantly enhance the photothermal effect. Furthermore, metformin loading led to high suppression and eradication of hepatoma cells when photothermally sensitized, but exhibited negligible effects on normal liver cells. Due to its excellent combination of T1/T2 MRI properties with sensitive chemotherapeutic and photothermal effects, our study highlights the promise of developing multifunctional nanomaterials for accurate multimodal imaging-guided, and highly sensitive therapy of liver cancer.

 

53. Wang, Junli ; Dou, Chenxi ; Chen, Lei ;Yan, Haiting; Meng, Lingjie ; Zhu, Jiangfeng; Wei, Zhiyi. High energy passively Q-switched Er-doped fiber laser based on Mo0.5W0.5S2 saturable absorber. Optical Materials Express. 2018,8:324-331. (IF=2.566)

 

           A passively Q-switched Er-doped fiber laser based on a novel transition metal sulfide (TMDs) Mo0.5W0.5S2 absorber is reported for the first time. There are two different types of Mo0.5W0.5S2-based saturable absorbers (SAs) that achieve Q-switching operation, one of which is depositing the Mo0.5W0.5S2 on the surface of the tapered fiber, and the maximum single pulse energy of 172.91 nJ and minimum pulse width of 1.42 mu s is obtained. While the other is transferring Mo0.5W0.5S2-PVA(polyvinyl alcohol: PVA) SA film onto a standard FC/APC fiber end face, the high single pulse energy of 246.5 nJ and the minimum pulse width is 1.92 mu s is obtained, and the modulation depth of SAs detected by the twin-detector method is 15%. The experiment results show that Mo0.5W0.5S2 can be considered as a promising candidate for pulse fiber laser applications and other photoelectric devices. 

 

52.  Hongxiao Wang, Xiaohui Zhang*, Yugang Duan，and Lingjie Meng*. Experimental and Numerical Study of the Interfacial Shear Strength in Carbon Fiber/Epoxy Resin Composite under Thermal Loads. International Journal of Polymer Science. 2018，doi.org/10.1155/2018/3206817.  (IF=1.718)

 

 

          This study examined the influence mechanism of temperature on the interfacial shear strength (IFSS) between carbon fiber (CF) and epoxy resin (EP) matrices under various thermal loads using experimental and numerical simulation methods. To evaluate the change in IFSS as a function of the increase in temperature, a microbond test was performed under controlled temperature environment from 23 ∘ C to 150 ∘ C. The experimental results showed that IFSS values of CF/EP reduce significantly when the temperature reaches near glass transition temperature. To interpret the effect of thermal loads on IFSS, a thermal-mechanical coupling finite element model was used to simulate the process of fiber pull-out from EP. The results revealed that temperature dependence of IFSS is linked to modulus of the matrix as well as to the coefficients of thermal expansion of the fiber and matrix.

 

2017年

 

51.  Daquan Wang, Yibo Ren, Yongping Shao and Lingjie Meng*. Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy. Polymer Chemistry. 2017，8,6938-6942.  (IF=4.927)

        It is a long-pursued goal to improve the antitumor efficiency while decreasing the systemic side effects of therapeutic agents of cancers. In this study, a multifunctional drug delivery system (DDS) for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene (PPZ) onto multi-walled carbon nanotubes (MWNTs) via one-pot in situ polymerization of doxorubicin (DOX) and bis-(4-hydroxyphenyl)-disulfide (HPS) with hexachlorocyclotriphosphazene. The DOX loading ratio and release rate were precisely tuned via the adjustment of the DOX to HPS molar ratio. MWNTs were used as a nanotemplate and near-infrared photothermal conversion agent for effective photothermal therapy. Remarkably, this multifunctional DDS selectively suppressed and killed cancer cells, but negligibly affected normal cells. Hence, this DDS demonstrates the proof-of-concept for effective chemo-photothermal synergistic therapy.

 

50. Daquan Wang, Yibo Ren, Yongping Shao, Demei Yu, Lingjie Meng*. Facile Preparation of Doxorubicin-Loaded and Folic Acid-Conjugated Carbon Nanotubes@Poly(N-vinyl pyrrole) for Targeted Synergistic Chemo–Photothermal Cancer Treatment. Bioconjugate Chemistry. 2017，DOI: 10.1021/acs.bioconjchem.7b00515.  (IF=4.485)

 

      We developed a bifunctional nanoplatform for targeted synergistic chemo–photothermal cancer treatment. The nanoplatform was constructed through a facile method in which poly(N-vinyl pyrrole) (PVPy) was coated on cut multiwalled carbon nanotubes (c-MWNTs); FA-PEG-SH was then linked by thiol–ene click reaction to improve the active targeting ability, water dispersibility, and biocompatibility and to extend the circulation time in blood. The PVPy shell not only enhanced the photothermal effect of c-MWNTs significantly but also provided a surface that could tailor targeting molecules and drugs. The resulting MWNT@PVPy-S-PEG-FA possessed high drug-loading ratio as well as pH-sensitive unloading capacity for a broad-spectrum anticancer agent, doxorubicin. Owing to its outstanding efficiency in photothermal conversion and ability in targeted drug delivery, the material could potentially be used as an efficient chemo–photothermal therapeutic nanoagent to treat cancer.

 

49. Songxia Yu, Zhiqiang Wang, Ruijun Cao, Lingjie Meng*. Microwave-Assisted Synthesis of Small and Water-Dispersible Lanthanide-Doped NaGdF4 Nanocrystals for PL/CT/MR Multimodal Imaging. SM Journal Clinical and Medical Imaging. 2017,3(1), 1011-1016.

 

 

     Multimodal imaging is advantageous in overcoming the deficiencies of individual imaging modalities. Herein, small, monodisperse and water-dispersible NaGdF4: Ln (Ln = Eu, Tb, Dy) Nano Crystals (NCs) were successfully prepared in a facile manner by one-pot microwave-assisted solvothermal reaction in ethylene glycol. The morphology, size distribution, zeta potential, and crystal structure of the resulting NCs were well characterised by transmission electron microscopy, Nano-ZS90 Zetasizer, and X-ray diffraction analyses. These as-synthesised NaGdF4: Ln (Ln = Eu, Tb, Dy) NCs exhibited a low cytotoxicity for Hela and C9H2 cells. Moreover, the doping concentrations of Eu3+, Tb3+, and Dy3+ ions were optimised for efficient Photoluminescence (PL) under the excitation of 273 nm in water. Furthermore, these NCs exhibited excellent relaxivity parameters (r1) in Magnetic Resonance (MR) imaging and Hounsfield units in X-ray Computed Tomography (CT) imaging in vitro. Therefore, these NCs have great potential to construct a unique platform for PL/CT/MR multimodal imaging simultaneously.

 

 

48. Songxia Yu, Zhiqiang Wang, Ruijun Cao, Lingjie Meng*. Microwave–assisted synthesis of water–disperse and biocompatible NaGdF₄: Yb,Ln@NaGdF₄ nanocrystals for UCL/CT/MR multimodal imaging. Journal of Fluorine Chemistry, 2017, 200, 77-83. (IF=1.879)

          In this paper, we have developed a series of rare earth fluoride nanocrystals (NCs) that can be used for multimodal imaging applications. Three highly monodisperse and water dispersible NaGdF₄:Yb,Ln@NaGdF₄ (Ln = Er, Tm, Ho) upconversion luminescence (UCL) NCs with an average size of 75 nm were prepared using a facile and efficient microwave–assisted solvothermal reaction in ethylene glycol (EG). The morphology, crystal structures, size distributions and zeta potentials of the resulting NCs were fully characterized by transmission electron microscopy (TEM), X–ray diffraction (XRD) and Nano–ZS90 Zetasizer. The obtained NaGdF₄:Yb,Ln@NaGdF₄ (Ln = Er, Tm, Ho) NCs could emit bright blue, green and red luminescence in water upon laser excitation at 980 nm. Furthermore, these core–shell NCs exhibited low cytotoxicity for HeLa and C9H2 cells, separately. Moreover, these NCs also displayed excellent Hounsfield units (HU) values in X–ray computed tomography (CT) imaging and high relaxivity parameters (r₁) in magnetic resonance (MR) imaging in vitro. Thus, these small, water–dispersible and biocompatible NCs show excellent potential as contrast agents for UCL/CT/MR multimodal imaging and other biomedical applications.

 

 

47.Dongfeng Dang*, Ying Zhi, Xiaochi Wang, Baofeng Zhao*, Chao Gao*, Lingjie Meng*.A₁-A-A₁ type small molecules terminated with naphthalimide building blocks for efficient non-fullerene organic solar cells. Dyes and Pigments. 2017, 137, 43-49.  (IF=3.767)

           Novel non-fullerene acceptors with an A₁-A-A₁ framework were designed and synthesized, in which benzothiadiazole and diketopyrrolopyrrole building blocks were employed as the A unit and naphthalimide units were incorporated as the A₁ units. Both acceptor systems exhibited a broadened absorption spectra from 300 nm to 700 nm in contrast to that of fullerene derivatives. Meanwhile, high-lying LUMO energy levels were also observed for both developed acceptors. To investigate photovoltaic properties of the acceptors, bulk-heterojunction organic solar cells were fabricated using an established electron donating polymer as the donor material. As anticipated, efficient non-fullerene OSCs with high V_oc values up to 1.01–1.12 V were achieved when the new molecules were employed as electron acceptors, leading to the PCE values of 1.23% and 1.64% in their solar cells. Our results here demonstrate that the A₁-A-A₁ type small molecule containing naphthalimide building blocks in molecular backbone could be the promising electron acceptor in organic solar cells.

 

 

46.Sweejiang Yoo, Jin Hou, Wenhui Yi*, Yingchun Li, Weiping Chen, Lingjie Meng*, Jinhai Si & Xun Hou. Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy. Sci Rep. 2017,DOI:10.1038/s41598-017-01118-3. (IF=4.122)

 

45.Daquan Wang, Chen Hou, Lingjie Meng,* Jiangang Long, Jiange Jing,Dongfeng Dang, Zhaofu Fei and Paul J. Dyson.Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of Doxorubicin combined with photothermal therapy. Journal of Material Chemistry B, 2017, 5, 1380 - 1387. (IF=4.776)

 

44. Liu Jing， Lingjie Meng*, Zhaofu Fei, Paul J Dyson, Jing Xunan, Liu Xing. MnO₂ Nanosheets as an Artificial Enzyme to Mimic Oxidase for Rapid and Sensitive Detection of Glutathione. Biosensor and Bioelectronics. 2017,69-74. (IF=8.173)

 

 

2016年

 

43. Dang Dongfeng*, Zhou Pei, Zhi Ying,  Bao Xichang*, Yang Renqiang, Meng Lingjie*, Zhu Weiguo*. Spirobifluorene-cored small molecules containing four diketopyrrolopyrrole arms for solution-processed organic solar cells. Journal of Materials Science, 2016,51(7):8018-8026. (IF=2.993)

 

          Spirobifluorene-linked three-dimensional small molecules of SF(DPP)(4) and SF(TDPP)(4) containing four diketopyrrolopyrrole arms were designed and synthesized. Both molecules displayed a broad and strong absorption in the region of 300-700 nm with suitable HOMO and LUMO energy levels as well as high charge carrier mobility. Meanwhile, solution-processed organic solar cells with a device structure of ITO/PEDOT:PSS/active layer/Ca/Al was also fabricated to investigate the photovoltaic properties of SF(DPP)(4) and SF(TDPP)(4). In contrast to that of star-shaped TPA(DPP)(3) in solar cells, enhanced photovoltaic performance with an impressive open circuit voltage of 0.95 V and short-circuit current density of 9.12 mA/cm(2) was achieved, leading to the maximum power conversion efficiency of 3.72 %. Our result here demonstrated that the three-dimensional-type small molecule in a D-A framework is a promising candidate as electron-donor materials for efficient organic solar cells.

 

 42. Dang Dongfeng*, Wang Xiaochi, Zhi Ying, Meng Lingjie, Bao Xichang*, Yang Renqiang, Zhu Weiguo*. Synthesis and characterization of D-A-A type regular terpolymers with narrowed band-gap and their application in high performance polymer solar cells. Organic Electronics. 2016,32, 237-243.(IF=3.68)

 

          Two novel D-A-A type regular terpolymers of PBDT-DTQ and PIDT-DTQ were designed and synthesized, in which benzodithiophene and indacenodithiophene building blocks were employed as the D unit, and quinoxaline building block was introduced as the A unit. Owing to the strong intra-molecular charge transfer effect in polymer backbone, much broader absorption spectra covering from 320 to 800 nm with the narrowed band-gap were obtained for the developed D-A-A type polymers in contrast to their corresponding D-A type polymers. On the other hand, compared with PBDT-DTQ, PIDT-DTQ exhibited a deeper HOMO energy level and also higher charge carrier mobility. To investigate the photovoltaic properties of PBDT-DTQ and PIDT-DTQ in detail, bulk hetero-junction polymer solar cells with a structure of ITO/PEDOT: PSS/Active Layer/Ca/Al were fabricated. PBDT-DTQ-based solar cells exhibited a moderate PCE value of 3.84%, however, an increased J(sc) of 11.42 mA/cm(2), V-oc of 0.86 V and FF of 65.77% was achieved for PIDT-DTQ-based device, leading to the maximum PCE up to 6.41%. Our results here demonstrated that using the regular terpolymers as electron donor materials could be an efficient way to broaden the absorption of polymers and improve the photovoltaic performance of PSCs.

 

4   41. Min Hu*, Dandan Ma, Chengcheng Liu, Jing Wang, Zhenxi Zhang and Lingjie Meng*. Intense white emission from a single-upconversion nanoparticle and tunable emission colour with laser power. Journal of Material ChemistryC 2016,4，6975.(IF=5.976)

    

    40. Dandan Ma, Xiang Xu, Min Hu,* Jing Wang, Zhenxi Zhang, Jian Yang, and Lingjie Meng*. Rare-Earth Based Nanoparticles with Simultaneously Enhanced Near-Infrared (NIR)-Visible (Vis) and NIR-NIR Dual-Conversion Luminescence for Multimodal Imaging. Chemistry-An Asian Journal 2016,11（7），1050-1058. (IF=3.692)

 

 

2015 年

 

39. Daquan Wang, Ying Hu, Lingjie Meng,* Xiaochi Wang and Qinghua Lu. One-pot synthesis of fluorescent and cross-linked polyphosphazene nanoparticles for highly sensitive and selective detection of dopamine in body fluids.RSC Advances 2015, 5, 92762-92768. (IF=2.936)

 

38. Songxia Yu, Ruijun Cao, Jun Li, Lingjie Meng*.  Controlled synthesis of NdF3 and NaNdF4 micro- or nanocrystals by one-pot microwave-assisted hydrothermal reaction. Journal of Fluorine Chemistry 2015, 178, 286-290.(IF=2.213)

 

37.  王晓驰，常刚，曹瑞军，孟令杰*。近红外荧光染料的结构、性质及生物荧光成像应用。化学进展，2015,27（7）794-805.

 

 

36.Dandan Ma, Lingjie Meng, Yuzhong Chen, Min Hu,* Yanke Chen, Chen Huang,* Jin Shang, Ruifeng Wang, Youmin Guo and Jian Yang. NaGdF4:Yb3+/Er3+@NaGdF4:Nd3+@Sodium-Gluconate: Multifunctional and Biocompatible Ultrasmall Core.Shell Nanohybrids for UCL/MR/CT Multimodal Imaging.ACS Applied Materials & Interfaces 2015, 7, 16257-16265.(IF=8.097)

 

 

35. 刘天辉，常刚，曹瑞军，孟令杰*。超顺磁性Fe3O4纳米粒子在磁共振造影中的应用。化学进展，2015,27（5）：601-613.

34. Lingjie Meng*, Chengqiang Xu, Tianhui Liu, Hua Li, Qinghua Lu* and Jiangang Long:One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging. Polymer Chemistry 2015, 6,3155-3163. (IF=4.927)

 

 

 33. Zhao Chen, Xiaochi Wang, Hua Li, Chao Li, Qinghua Lu, Guang Yang,Jiangang Long and Lingjie Meng*:Controllable and mass fabrication of highly luminescent N-doped carbon dots for bioimaging applications. RSC Advances 2015, 5, 22343-22349. (IF=2.936)

 

 

 32. Lijuan Sun, Tianhui Liu, Hua Li, Liang Yang, Lingjie Meng*, Qinghua Lu*, and Jiangang Long: Fluorescent and Cross-linked Organic−Inorganic Hybrid Nanoshells for Monitoring Drug Delivery.  ACS Applied Materials & Interfaces 2015, 7, 4990-4997.  (IF=8.097)

 

 

2014 年

 

 31.  Meng Lingjie*, Xia Wenjian, Liu Li, Niu Lvye, Lu Qinghua*. Golden Single-Walled Carbon nanotubes Prepared Using Double Layer Polysaccharides Bride for Photothermal Therapy. ACS Applied Materials and Surface, 2014,30, 4485-64. (IF=8.097)

 

30. Hu Ying, Meng Lingjie*, Lu Qinghua*. "Fastening" Porphyrin in Highly Cross-linked Polyphosphazene Hybrid Nanoparticles: Powful Red Fluorescent Probe for Detecting Mercury Ion. Langmuir, 2014, 6(7):4989-96.  (IF=3.789)

 

 

 

  

2013 年

 

29. Hu ying, Meng Lingjie*, Niu Lvye, Lu Qinghua*. Facile Synthesis of Superparamagnetic Fe3O4@polyphosphazene@Au Shells for Magnetic Resonance Imaging and Photothermal Therapy. ACS Applied Materials and Surface, 2013, 5(11), 4586-91. (IF=8.019)

 

 

 

 

 

28.      Hu ying, Meng Lingjie*, Niu Lvye, Lu Qinghua*. Highly Cross-linked and Biocompatible Polyphosphazene Coated Fe3O4 Nanoparticles for Magnetic Resonance Imaging. Langmuir, 2013, 29(29):9156-63. (IF=3.789)

 

2012年

 

27. Niu Lvye, Meng Lingjie*, Lu Qinghua*. Folate-Conjugated PEG on Single Walled Carbon Nanotubes for Targeting Delivery of Doxorubicin to Cancer Cells. Macromolecular Bioscience 2013, 13(6):735-44. (IF=3.392)

 

  26. Meng Lingjie, Niu Lvye, Li Ling, Lu Qinghua*, Fei Zhaofu, Dyson Paul J*. Gold nanoparticles grown on ionic liquid-functionalized single-walled carbon nanotubes: new materials for photothermal therapy. Chemistry-A European Journal, 2012，18(42) , 13314-13319. (IF=5.319)

 

 

25.      Hongdan Peng, Lingjie Meng, Lvye Niu, Qinghua Lu. Simultaneous Reduction and Surface Functionalization of Graphene Oxide by Natural Cellulose with the Assistance of the Ionic Liquid. J. Phys. Chem. C, 2012, 116 (30), pp 16294–16299。 (IF=4.484)

 

 

 24.      Peng, Hongdan, Meng, Lingjie, Lu, Qinghua, Zhaofu Fei, Paul J Dyson. Fabrication of reduced graphene oxide hybrid materials that exhibit strong fluorescence. Journal of Material Chemisty, 2012, 20(26): 5493-8.  (IF=6.010)

 

 

23.      Meng Lingjie, Zhang Xiaoke, Lu Qinghua*, Fei Zhaofu, Dyson Paul J. Single walled carbon nanotubes as drug delivery vehicles:targeting doxorubicin to tumors. Biomaterials, 2012, 33, 1689-1697.  (IF=8.806)

 

 

22.      Ji Zongfei, Lin Gaofeng, Lu Qinghua, Meng Lingjie*, Shen Xizhong, Dong Ling, Fu Chuanlong, Zhang Xiaoke. Targeted Therapy of SMMC-7721 Liver Cancer in Vitro and in Vivo with Carbon Nanotubes Based Drug Delivery System. Joural of Colloid and Interface Science, 2012, 365,143-149.  (IF=5.019)

 

 

21. Da Xi, Sheng Dong, Xiaoxi Meng, Qinghua Lu, Lingjie Meng* and Jin Ye ，Gold nanoparticles as computerized tomography (CT) contrast agents. RSC Adv., 2012,2, 12515-12524.  (IF=2.293)

 

 

 

2010年

 

20.      Zhou Junfeng, Meng Lingjie*, Lu Qinghua*, Feng Xinliang. One-pot Synthesis of Highly Magnetic Sensitive Nanochains Coated with Highly Cross-Linked and Biocompatible Polymer. Angew Chemistry International Edit. 2010, 49, 8476-80.  (IF=12.102)

19.      Zhou Junfeng, Meng Lingjie*, Lu Qinghua*. Core@Shell Nanostructures for Photothermal Conversion: Tunable Noble Metal Nanoshells on Cross-linked Polymer Submicro-spheres. Journal of Material Chemisty, 2010, 20(26): 5493-8. (IF=6.01)

18.      Meng Lingjie*, Fu Chuanlong, Lu Qinghua, Fei Zhaofu*, Dyson Paul J. Photochemical Behavior of High Quantum Yield SWNTs Functionalized with Anthracene Salts. Chemistry-A Asian Journal, 2010, 9(5):1988-1991.  (IF=4.592)

17.      Meng Lingjie*, Fu Chuanlong, Lu Qinghua, Fei Zhaofu*, Dyson Paul J. Coordination chemistry on the surface of single-walled carbon nanotubes. Inorg. Chim. Acta. 2010, 363, 3926-31. (IF=2.264)

16.      Zhang Xiaoke, Meng Lingjie, Wang Xuefeng, Lu Qinghua. Preparation and Cellular Uptake of pH-Dependent Fluorescent Single-Wall Carbon Nanotubes. Chemistry-A European Journal, 2010,16,556-61.  (IF=5.019)

 

15. Lin Gaofeng,  Meng Lingjie, Zhang Xiaoke, Lu Qinghua: Non-Covalent Separation of Metallic and Semiconducting Single-Walled Carbon Nanotubes. Progress in Chemistry. 2010, 22, 331-337.

 

 

 

14. Xia Wenjian, Meng Lingjie, Liu Li, Lu Qinghua: Carbon Nanotubes Decorated with Noble Metal Nanoparticles. Progress in Chemistry. 2010, 22, 2298-2308.

 

13.      Fei Zhaofu, Zhu Dunru, Yang Xue, Meng Lingjie, Lu Qinghua, et al. An Internal Fluorescent Probe Based on Anthracene to 8319)

2009年

12.  Meng Lingjie, Fu Chuanlong, Lu Qinghua (2009). Advanced technology for functionalization of carbon nanotubes. Process in Naturnal Science, 2009,19,801-810.

11.  Zhou Junfeng, Meng Lingjie, Lu Qinghua, Fu Jianwei, Huang Xiaobin. Superparamagnetic submicro-megranates: Fe₃O₄ nanoparticles coated with highly cross-linked organic/inorganic hybrids. Chemical Communications, 2009, 42:6370-2.  (IF=6.29)

10.  Zhang Xiaoke, Meng Lingjie, Lu Qinghua, Fei Zhaofu, Dyson Paul J. Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials, 2009, 30: 6041-7.  (IF=8.557)

9.  Zhang Xiaoke, Meng Lingjie, Lu Qinghua. Cell behaviors on polysaccharide-wrapped single-wall carbon nanotubes: a quantitative study of the surface properties of biomimetic nanofibrous scaffolds. ACS Nano, 2009, 3:3200-6.  (IF=13.709)

 

8.  Li Ling, Meng Lingjie, Zhang Xiaoke, Fu Chuanlong,Lu Qinghua. Ionic liquid- associated synthesis of water-soluble and biocompatible cellulose/SWCNTs complex. Journal of Material Chemisty, 2009, 19, 3612-7.  (IF=6.101)

 

2008年

 

7.  Fu Chuanlong, Meng Lingjie, Lu Qinghua, Fei Zhaofu, Dyson Paul J. A facile strategy for preparation of fluorescent SWNT complexes with high quantum yields based on ion exchange. Advanced Functional Materials. 2008, 18, 857-64. (IF=13.325)

6.  Zhang Jichun, Meng Lingjie, Zhao Dongbin, Fei Zhaofu, Lu Qinghua, Dyson Paul J. Fabrication of dendritic fold nanoparticles by use of an ionic polymer template. Langmuir, 2008, 24, 2699-704.  (IF=4.457)

5.  Ren Lanzheng, Meng Lingjie, Lu Qinghua, Fei Zhaofu, Dyson Paul J. Fabrication of gold nano- and microstructures in ionic liquids - A remarkable anion effect. Joural of Colloid and Interface Science, 2008, 323, 260-6. (IF=5.019)

 4. Ren Lanzheng，Meng Lingjie， Lu Qinghua. Mass Synthesis of Large, Single-crystal Gold Nanoplates Using a Pyridinium-based Ionic Liquid. 2008，2nd IEEE International Nanoelectronics Conference.

 

3. Ren Lanzheng，Meng Lingjie， Lu Qinghua. Fabrication of octahedral gold nanostructures using an alcoholic ionic liquid. Chemistry Letter. 2008,37,106-107. (IF=1.625).

2. Fu ChuanLong; Meng LingJie; Lu QingHua. 'Hierarchical self-assembly' of helical amylose/SWNTs complex. Science in China Series B-Chemistry. 2008, 51, 269-274.

2007年

 

1.  Fu Chuanlong, Meng Lingjie, Lu Qinghua, Zhang Xiaoke, Gao Chao. Large-scale production of homogeneous helical amylose/single-walled nanotubes complexes with good biocompatibility. Macromolecule Rapidly Commmunacation, 2007, 28, 2180-4.  (IF=4.441)

 

 

 

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