科学研究

主要研究领域

食品营养学

糖生物学

天然产物功能研究

主持项目

1. 陕西省重点研发计划No.2022SF-069  仿生多层次梯度力学相适应的髋关节股骨头损伤修复研究，2022.1~2023.12、6万元、主持。

2、陕西省自然科学基础研究计划项目，No.2018JM7055、金丝桃苷基于ATF3调控结肠癌分子机制研究、2018.1~2019.12、3万元、已结题、主持。

3、国家林业公益性行业科研专项，No. 201304811、林源食用叶类深加工与产品质量控制技术研究》子项目， 2013.1~2016.12、34万元、已结题、主持。

4、陕西省自然科学基础研究计划项目，No.2014JM4100、柿叶黄酮基于调控氧化/抗氧化和骨吸收/骨形成平衡耦合的抗骨质疏松症作用及分子机制研究、2014.1~2015.12、2万元、已结题、主持。

5、国家自然科学基金青年基金项目，No. 31101266、硫酸酯壳聚糖对胰岛β细胞氧化损伤的保护作用及其机制研究、2012.1~2014.12、22万元、已结题、主持。

6、陕西省自然科学基础研究计划项目，No. 2011JM4025、壳聚糖衍生物对胰岛β细胞氧化损伤的作用、2011.1~2012.12、2万元、已结题、主持。

参与项目 

1、 国防XXXH863计划计划项目，17-XXX-XX-XX-XXX-XX-11，XXXX的生物物理机制研究, 2017.07-2018.06，30万元，结题，参与 

2、国家自然科学基金青年项目，51605370，自适应织构化柔性生物对抗膜的海洋装备污着防护及其减阻机理研究，2017.01-2019.12，20万元，在研，参与 

3、国家自然科学基金面上项目，51175406，全同金属摩擦副表面多层次织构接触引导细胞膜的摩擦失活与自修复机制研究，2012.1-2015.12，58万元，结题、参与

科研论文

1. Liguo Qin, Chaoyong Gong, Mahshid Hafezi, Fagla Jules Mawignon, Xiaodong Huang, Qunfeng Zeng, Yali Zhang,* and Guangneng Dong；Carboxylic Multi-Walled Carbon Nanotubes as Reinforcing Fillers in Ionic Polymer–Metal Composite Actuators with Enhanced Driving Performance，Adv. Eng. Mater. 2022, 2200008
2. Dan Xu, Jiu Xiao , Dazhao Jiang , Yaxin Liu, Zhuolun Goua, Jing Li, Mingyao Shi, Xinyi Wang , Yaxuan Guo, Lingyan Ma, Hong Yin, Li Guo , Chunhui Zhu , Yali Zhang ,Hui Guo, Inhibitory effects of a water-soluble jujube polysaccharide against biofilm-forming oral pathogenic bacteria, International Journal of Biological Macromolecules, 208(2022)1046-1062 (中科院1区，IF6.953)
3. Zhang Y, Yu X, Wang M, Ding Y, Guo H, Liu J, Cheng Y*: Hyperoside from Z. bungeanum leaves restores insulin secretion and mitochondrial function by regulating pancreatic cellular redox status in diabetic mice. Free Radic Biol Med 2021;162:412-422
4. 程梦蓉，秦立果，姜大昭，卢晓云，张雅利*．β-羟基丁酸调节糖尿病患者口腔菌群结构和丰度［J］．中国科技论文2020, 15(12) ：1377-1385
5. Kaihong Guo, Yali Zhang, Xinlei Fang, Peiyao Fan, Sen Shang, Fan Fan, Hongyan Wu, Menghua Man, Yanzhao Xie，Xiaoyun Lu, Effects of acute exposure to ultra-wideband pulsed electromagnetic fields on the liver and kidneys of mice, ELECTROMAGNETIC BIOLOGY AND MEDICINE，https://doi.org/10.1080/15368378.2020.1737806
6. Liguo Qin, Hongjiang Sun, Mahshid Hafezi，Yali Zhang,* Polydopamine-Assisted Immobilization of Chitosan Brushes on a Textured CoCrMo Alloy to Improve its. Tribology and Biocompatibility, Materials. (SCI) 2019, 12(18):3014-3029
7. Liguo Qin* , Mahshid Hafezi, Hao Yang, Guangneng Dong, Yali Zhang*, Constructing a Dual-Function Surface by Microcasting and Nanospraying for E_cient Drag Reduction and Potential Antifouling Capabilities. Micromachines (SCI) 2019, 10(7):490-505
8. 於晓敏，程梦蓉，亓树艳，张雅利*，中国应急食品现状与发展，食品工业，2019（12）：236-240
9. 於晓敏，秦立果，亓树艳，张雅利*, 壳聚糖衍生物-Ca配合物对成骨细胞活性的影响, 中国科技论文,2019 14(4):378-384
10. 秦立果，孙红江，杨浩，曾群锋，张雅利，董光能, 壳鲨鱼皮盾鳞结构减阻性能数值模拟, 中国科技论文,2019 14(12):1271-1277
11. Yali Zhang, Mimi Wang, Huanhuan Dong, Xiaomin Yu and Jingfang Zhang：Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes. International journal of molecular medicine. (SCI) 2018,41:77-86
12. Yali Zhang, Yucheng Guo, Mimi Wang, Huanhuan Dong, Jingfang Zhang and Liyu Zhang: Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis via enhancement of oxidative stress in human colorectal cancer SW620 cells. ONCOLOGY REPORTS. (SCI) 2017,38(6):3319-3326
13. Yali Zhang, Huanhuan Dong, Jingfang Zhang, Liyu Zhang：Inhibition effect of hyperoside isolated from the Zanthoxylum bungeanum leaves via induction of apoptosis and p53 signaling pathway on human colon cancer SW620 cells，Molecular medicine Reports. (SCI) 2017, 16: 1125-1132 
14. Zhang Y, Dong H, Wang M and Zhang J: Quercetin Isolated from Toona sinensis Leaves Attenuates Hyperglycemia and Protects Hepatocytes in High-Carbohydrate/High-Fat Diet and Alloxan Induced Experimental Diabetic Mice. J Diabetes Res  (SCI) 2016: 8492780, 2016.
15. Ding Y, Ren K, Dong H, Song F, Chen J, Guo Y, Liu Y, Tao W, Zhang Y *. Flavonoids from persimmon Diospyros kaki L leaves inhibit proliferation and induce apoptosis in PC-3 cells by activation of oxidative stress and mitochondrial apoptosis. Chemico-Biological Interactions  275:210-217,2017
16. Liguo Qin, Hongxing Wu, Junde Guo, Xinan Feng, Guangneng Dong, Jinyou Shao, Qunfeng Zeng, Yali Zhang*, Yuanbin Qin, Fabricating hierarchical micro and nano structures on implantable Co–Cr-Mo alloy for tissue engineering by one-step laser ablation. Colloids and Surfaces B: Biointerfaces. 2018 , 161 :628-635  
17. Liguo Qin, Huanhuan Dong, Ziqing Mu, Yali Zhang*, Guangneng Dong. Preparation and bioactive properties of chitosan and casein phosphopeptides composite coatings for orthopaedic implants. Carbohydrate Polymers 2015,133:236-244 
18. Liguo Qin, Hongjiang Sun, Mahshid Hafezi, Yali Zhang*, Biomimetic surfaces with hierarchical structure using microsized texture and nanosized Cu particles for superhydrophobic. Advanced Materials Letters, 2019,10(8):569-573
19. 方堃，周文旭，魏挺，徐蕾，杨浩杰，卢媛媛，刘江，庄稼，张雅利*,２型糖尿病患者不同治疗方式对血糖水平的影响，陕西医学杂志，2017,1(46):57-59  
20. 秦立果，杨浩，董光能，张雅利,柔性表面织构化在海洋装备减阻与防污上的应用.表面技术,2019，48(6):150-157
21. Yali Zhang, Xiaoyun Lu, Qian-Qian Liu, Ming-Chuan Li, Zhi-Qian Yang, Jian-Gang Ma. Production and Characterization of Poly(ethylene glycol) Modified Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) with Flexible Molecular Weight. Chinese Journal of Polymer Science (SCI), 30:101-111, 2012
22. Lijun Sun, Jianbao Zhang, Kun Fang, Yan Ding, Liyu Zhang, Yali Zhang*. Flavonoids from persimmon (Diospyros kaki) leaves (FPL) attenuate H2O2-induced apoptosis in MC3T3-E1 cells via the NF-κB pathway. Food Funct. (SCI) 5:471-479,  2014
23. Hao Xu，Yali Zhang, Junqing Sun, Jinhong Wei, Lijun Sun, Jianbao Zhang. The effect of distinct sources of Ca²⁺ on cardiac hypertrophy in cardiomyocytes，Experimental Biology and Medicine (SCI), 237(3):271-8, 2012. 
24. Liguo Qin, Qunfeng Zeng, Wenxing Wang, Yali Zhang*, Guangneng Dong  Response of MC3T3-E1 osteoblast cells to the microenvironment produced on Co-Cr-Mo alloy using laser surface texturing. Journal of Materials Science, (SCI) 49(6)：2662-2671, 2014
25. Xiaoyun Lu, Hui Guo, Lijun Sun, Liyu Zhang, Yali Zhang* . Protective effects of sulfated chitooligosaccharides with different degrees of substitution in MIN6 cells International Journal of Biological Macromolecules, (SCI) 52: 92-98, 2013
26. Xiaoyun Lu, Xiaoyan Mo, Hui Guo, Yali Zhang*. Sulfation modification and anticoagulant activity of the polysaccharides obtained from persimmon (Diospyros kaki L.) fruits, International Journal of Biological Macromolecules, (SCI) 51: 1189-1195, 2012  
27. Xiaoyun Lu, Hui Guo, Yali Zhang*. Protective effects of sulfated chitooligosaccharides against hydrogen peroxide-induced damage in MIN6 cells, International Journal of Biological Macromolecules, (SCI) 50:50-58, 2012.
28. Lijun Sun, Jianbao Zhang, Xiaoyun Lu, Liyu Zhang, Yali Zhang*. Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves, Food and Chemical Toxicology, (ESI) 49 :2689-2696, 2011    
29. Yan Ding , Yali Zhang*, Hui Guo，Effect of Polysaccharides from Fresh Persimmon (Diospyros kaki) Fruits and its Sulfated Derivates on the Immunomodulatory Activity of Mouse Peritoneal Macrophage Cells, Advanced Materials Research，(EI) 643, 108-115, 2013
30. 任凯，任立刚，丁岩，张雅利， Saposin C 抑制雄激素受体的多泛素化以及在蛋白酶体中的降解，中国生物化学与分子生物学报，30(5)，462-467，2014
31. 任凯，丁岩，成凡，付慧，张雅利，鞘脂激活蛋白C通过上调雄激素受体的表达与活性促进LNCaP细胞的增殖，学报(医学版)， 34（5），619-622，2013
32. Xiaoyun Lu, Hui Guo, Yali Zhang*. Protective effects of sulfated chitooligosaccharides with different degrees of substitution against hydrogen peroxide -induced damage in MIN6 Cells, International Journal of Biological Macromolecules (SCI), 82:52-58, 2011 8
33. Yali Zhang, Xiaoyun Lu, Zhongbin Fu, Zibao Wang, Jianbao Zhang. Sulfated modification of a polysaccharide obtained from fresh persimmon (Diospyros kaki L.) fruit and antioxidant activities of the sulfated derivatives [J]. Food Chemistry (SCI) 127: 1084–1090, 2011
34. Yali Zhang, Xiaoyun Lu, Yuning Zhang, Liguo Qin, Jianbao Zhang. Sulfated modification and immunomodulatory activity of water-soluble polysaccharides derived from fresh Chinese persimmon fruit [J]. International Journal of Biological Macromolecules (SCI), 46(1):67-71, 2010
35. Yali Zhang, Jianbao Zhang, Xiaoyan Mo, Xiaoyun Lu, Yuning Zhang, Liguo Qin. Modification, characterization and structure–anticoagulant activity relationships of persimmon polysaccharides [J]. Carbohydrate Polymers (SCI), 82:515-520,2010
36. Qin L*, Dong G, Zhang Y, Shao J, Zeng Q. THE SELF-REPAIR BEHAVIOR OF CELL OVERLAY INDUCED BY THE SURFACETEXTURE ON Co-Cr-Mo ALLOY，44th Leeds-Lyon Symposium on Tribology, September 4-6, 2017, Lyon, France. (会议)
37. 秦立果*，郭俊德，吴红星，董光能，邵金友，张雅利，曾群锋.织构化表面接触引导细胞膜的自修复.2016 年东部地区摩擦学论坛暨第八届生物摩擦学与医学内植物工程学术研讨会. P138. (会议)
38. Qin L, Lin P, Zhang Y, Dong G*, Zeng Q*. Influence of surface wettability on the tribological properties of laser textured Co–Cr–Mo alloy in aqueous bovine serum albumin solution. Applied Surface Science, 268: 79-86, 2013.IF 3.387
39. 李明川，张雅利，卢晓云*，朱新亮，陈旭，李 崇，马惺锋，唐秉韬. 3-羟基丁酸-3-羟基己酸共聚酯纳米颗粒作为雷帕霉素缓释载体的应用研究. 学报医学版， 34（5）： 144−148, 2013
40. Ming-Chuan Li, Qian-Qian Liu, Xiao-Yun Lu*, Ya-Li Zhang and Lei-Lei Wang. Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 immobilized polyhydroxyalkanoate nanoparticles for use as an immune activation agent. BMC Biotechnology.  2012：12(1): 43
41. Xiaoyun Lu, Elisa Ciraolo, Rachele Stefenia, Guoqiang Chen , Yali Zhang, Emilio Hirsch Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines[J]. Appl Microbiol Biotechnol (SCI), 89:1423–1433,2011
42. Xiaoyun Lu, Yali Zhang, Liang Wang. Preparation and in vitro Drug-Release Behavior of 5-Fluorouracil-Loaded Poly(hydroxybutyrate-co-hydroxyhexanoate) micro- and nanoparticles [J]. Journal of Applied Polymer Science (SCI) 116(5):2944–2950, 2010     

授权专利

1. 张雅利，姜大昭，张建保，金心平，一类基于竹荪蛋提取物的美容外用品中的应用及基于其的美容外用品 ZL202010784605.X
2. 张雅利，程梦蓉，郭辉，金心平，亓树艳， 柿叶黄酮提取物在制备口腔护理产品中的应用，ZL201910838353.1
3. 张建保，张雅利，姜大昭，金心平，一类基于竹荪蛋提取物的活性抑菌敷料,ZL2020107855170.1
4. 秦立果，龚朝永，杨雷，张辉，杨浩，孙红江，曾群锋，张雅利，董光能,基于IPMC电活性聚合物的主动减阻材料及其制备方法 ZL202110302844.1

出版专著

主编 张雅利、郭辉， 《天然产物活性研究》 出版社，2017

教学

教改项目

[1].  张雅利，2018年~2019.12， “名师、名课、名教材”建设工程培育项目，主持

[2].  张雅利，2018本科实践教学改革研究专项项目，项目驱动的生物专业《综合实验》教学改革与创新，主持

[3].  张雅利，2019-01-01~2020-12-31，研究生教育改革项目，项目驱动的《功能食品研发实务》课程建设研究 ，主持

[4].  张雅利，2012.1~2012.12，生物工程《综合开放实验》课程建设与实践，主持

教学文章

[1].  张雅利，孔宇， 亓树艳， 莫晓燕，生物工程综合实验课程的构建与实施，教育教学论坛，2014.3（13），202-204

[2].  孔宇，张雅利，莫晓燕，增强综合开放实验课程教学效果措施探索，实验技术与管理，2014,31,33-35

[3].  莫晓燕，张雅利，李剑君,本科生综合实验课程的探索与思考, 中国生物医学工程联合学术年会,2007

教学获奖

(1) 张雅利，2015年，《生物工程专业综合实践环节特色贯通培养体系》，大学第十四届教学成果二等奖。

(2) 张雅利，校优秀实习队

出版教材

(1) 主编 张雅利 龙建纲 《高等生物学实验技术》科学出版社，2020.2

(2) 主编 张雅利 《营养与健康》出版社，2018.10

(3) 《蛋白质工程》科学出版社，2012

相关专著

[1].  张雅利主编，基础篇-图解维生素矿物质金典，ISBN：9787506264331世界图书出版公司，2007/04，25万字

[2].   张雅利主编，应用篇-图解维生素矿物质金典，ISBN：9787506264331世界图书出版公司，2007/04，25万字

[3].   张雅利主编，对抗自由基(增强免疫抗衰老)，ISBN：9787506264331世界图书出版公司，2007/04，25万字

[4].   张雅利主编，应用篇-图解维生素矿物质金典，ISBN：9787506293891世界图书出版公司，2008/07，24万字

[5].   张雅利主编，营养运动瘦身计划，ISBN: 7506293889 世界图书出版公司，2008/03，24万字

[6].   张雅利主编，人体酸碱平衡手册-膳食·运动·美容·疗疾，ISBN: ISBN:7506293870 世界图书出版公司，2008/03，20万字

[7].   张雅利主编，健康水医生，ISBN: 9787506293907 世界图书出版公司，2008/03，20万字

[8].   张雅利主编，更年期保健手册，ISBN: 9787506299817 世界图书出版公司，2009/05，22万字

[9].   张雅利主编，抗衰防病金钥匙-无与伦比的SOD，ISBN: 97898828696677 中国科学教育出版社，2010/11，12万字

[10].   张雅利主编，吃出健康美丽俏佳人-胶原蛋白，ISBN: 9789882809604 中国科学教育出版社，2011/8，12万字