Basic Information

​​​​​​​

Jiangang Long，PH. D.

Biology Professor

​​​​​​​Vice Dean of Graduate School, Xi’an Jiaotong University

Institute of Mitochondrial Biology and Medicine of Xi’an Jiaotong University School of Life Science and Technology

Research Interests

Mitochondrial Degeneration & Therapeutic Intervention in Aging, Neurodegenerative Diseases and Metabolic Syndromes

Contact Information

Tel:+86-29-8266 4232

Fax:+86-29-8266 5849

Email:jglong@mail.xjtu.edu.cn
 

Web Page:​​​​​​​http://gr.xjtu.edu.cn/web/jglong

​​​​​​​
Address: No. 28 W. Xianning Road, Xi’an 710049, China

Research Team

yes Long's team is dedicated to the research of mitochondrial nutrients and drugs, creating mitochondrial nutrients and drugs for mitochondrial-related chronic diseases (Alzheimer's disease, diabetes, etc.) and mitochondrial metabolism remodeling in extreme environments, and developing targeted regulatory strategies for preventing and treating mitochondrial-related diseases.

 

yes The team has 7 professors, associate professors and assistant professors, and more than 20 master's and doctoral students, with a complete talent echelon, outstanding teaching and research capabilities, and active teamwork.

 

yes The team maintains extensive cooperation with Harvard University, Oxford University, Kyushu University and other internationally renowned research teams, and invites researchers from China Astronaut Center, Academy of Military Science, Shaanxi Pharmaceutical Group, Honghui Hospital and other important cooperative units to serve as collaborative mentors.

 

yes In recent years, the team has presided over over more than 10 provincial and ministerial projects such as the National Basic Research Program of China and the Natural Science Foundation of China, and has published more than 10 research papers in the J Neurosci, Cell research, Antioxidant redox research and the National Academy of Sciences of China. He has published more than 140 papers in J Neurosci, Cell research, Antioxidant redox signaling and other international and domestic journals.

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Education

2006     Ph.D. Biochemistry and Molecular Biology

Dept. of Chemistry and Molecular Biochemistry, Second Military Medical University and Institute for  
  Nutritional Sciences, Chinese Academy of Sciences

2002     M.S. Public Health

            Dept. of Public Health, Second Military Medical University

1996     B.S. Pharmacy

  Pharmacy school, Second Military Medical University

 

Research Area

Mechanisms of aging and related diseases and their early intervention strategies

The research team focuses on scientific issues in the metabolism and degeneration mechanisms of mitochondria, the core organelles of cellular energy metabolism, and explores the mitochondrial mechanisms of aging, Alzheimer's disease, and type 2 diabetes mellitus, including the following research directions:
1. Molecular mechanisms of mitochondrial degeneration in neurodegenerative diseases.
2. mitochondrial metabolic regulation and repair in special environments such as aerospace and other mitochondrial nutrient and drug research
3. Mitochondrial nutrient and drug research

 

Publications

 

Publication (* corresponding author)

Years：2024 | 2023 | 2022 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2010... 

 

2024

  1. Jia Y, Chen K, Du M, Zhao W, Chen Y, Cheng J, Zhao L, Liu J, Long J*. Auricularia auricula-judae Attenuates the Progression of Metabolic Syndrome in High-Fat Diet-Induced Obese Rats: Enzymatic Pre-Digestion Technology Is Superior to Superfine Grinding Method. Foods. 2024 Jan 26;13(3):406. （中科院2区，IF=5.2）

 

2023

  1. Xu F, Yang Z, Wang L, Meng D, Long J*. MESPool: Molecular Edge Shrinkage Pooling for hierarchical molecular representation learning and property prediction. Brief Bioinform. 2023 Nov 22;25(1):bbad423. （中科院1区，IF=9.5）
  2. Cheng D, Long J, Zhao L, Liu J. Hydrogen: A Rising Star in Gas Medicine as a Mitochondria-Targeting Nutrient via Activating Keap1-Nrf2 Antioxidant System. Antioxidants (Basel). 2023 Nov 12(12), 2062. （中科院1区，IF=7.0）
  3. Liu X, Zhang X, Zhao L, Long J, Feng Z, Su J, Gao F, Liu J. Mitochondria as a sensor, a central hub and a biological clock in psychological stress-accelerated aging. Ageing Res Rev. 2023 Nov 27:102145. （中科院1区，IF=13.1）
  4. Han X, Yang F, Zhang Z, Hou Z, Sun Q, Su T, Lv W, Wang Z, Yuan C, Zhang G, Pi X, Long J*, Liu H. 4EBP2-regulated protein translation has a critical role in high-fat diet-induced insulin resistance in hepatocytes. J Biol Chem. 2023 Nov 299(11):105315. （中科院2区，IF=4.8）

  5. Liang B, Shi L, Du D, Li H, Yi N, Xi Y, Cui J, Li P, Kang H, Noda M, Sun X, Liu J*, Qin S*, Long J*. Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study. Antioxidants (Basel). 2023 Jun 9;12(6):1245.（中科院1区，IF=7.675）

  6. Sun Q, Shi L, Li S, Li J, Zhang R, Huang X, Shao Y, Feng Z, Peng Y, Yang Z, Liu J, Liu H*, Long J*. PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis. Free Radic Biol Med. 2023 Aug 20;205:13-24.（中科院1区，IF= 7.4）

  7. Yang Z, Fu X, Zhao Y, Li X, Long J, Zhang L. Molecular insights into the inhibition mechanism of harringtonine against essential proteins associated with SARS-CoV-2 entry. Int J Biol Macromol. 2023 Jun 15;240:124352.（中科院1区，IF=8.2）

  8. Ma Q, Gao J, Fan Q, Yang T, Zhao Z, Zhang S, Hu R, Cui L, Liang B, Xie X, Liu J, Long J*. Thinned young apple polyphenols may prevent neuronal apoptosis by up-regulating 5-hydroxymethylcytosine in the cerebral cortex of high-fat diet-induced diabetic mice. Food Funct. 2023 Apr 3;14(7):3279-3289.（中科院1区，IF=6.317 ）

  9. Liu X, Fang L, Wang J, Huang S, Li A, Liu H, Lu Z, Long J, He M. Preparation of ZIF-8@[C2mim][BF4]/Pebax mixed-matrix membranes through a impregnation strategy for enhancing the separation of difluoromethane (R32) from refrigerant blend R410A. Chem Eng Res Des. 2023,199, 530-540. （中科院3区，IF=3.9）

2022

  1. Wang X, Zhang X, Cao K, Zeng M, Fu X, Zheng A, Zhang F, Gao F, Zou X, Li H, Li M, Lv W, Xu J, Long J, Zang W, Chen J, Gao F, Ding J, Liu J, Feng Z. Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy. Nat Commun. 2022 Jul 8;13(1):3947.（中科院1区，IF= 17.694）

  2. Yang Z, Zhang Z, Zhao Y, Ye Q, Li X, Meng L, Long J, Zhang S, Zhang L. Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation. Front Pharmacol. 2022 Jun 20;13:935898. （中科院2区，IF=5.988）

  3. Guo Q, Wang L, Liu Z, Wang H, Wang L, Long J, Liao S. Different effects of maternal homocysteine concentration, MTHFR and MTRR genetic polymorphisms on the occurrence of fetal aneuploidy. Reprod Biomed Online. 2022 Dec 45(6):1207-1215. （中科院2区，IF=4.567）

  4. Gao J, Wang Z, Gao P, Fan Q, Zhang T, Cui L, Shi L, Liu Z, Yang Z, He L, Wang C, Li Y, Qu L, Liu J, Long J*. Daphnetin Alleviates Senile and Disuse Osteoporosis by Distinct Modulations of Bone Formation and Resorption. Antioxidants (Basel). 2022 Nov 29;11(12):2365.（中科院1区，IF=7.675）
  5. Wang Y, Hu X, Long J, Diao J. Epigenetic optical sensing of 5-hydroxymethylcytosine at the single-molecule level. Sens Actuators B Chem. 2022 358, 131500（中科院1区，IF=8.4）

  6. Chen Y, Hu S, Wu X, Xie Z, Wang Y, Wang B, Li X, Pei Y, Gu Y, Huang K, Huo J, Wei A, Bi C, Lu Z, Song Q, Xu H, Kang X, Shao S, Long J, Liu J, Zhou Z, Huang R, Chai Z, Wang C.Synaptotagmin-1 is a bidirectional Ca2+ sensor for neuronal endocytosis. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2111051119. （中科院1区，IF=11.205）

  7. Gao P, Wang Z, Lei M, Che J, Zhang S, Zhang T, Hu Y, Shi L, Cui L, Liu J, Noda M, Peng Y, Long J*.Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease. Pharmacol Res. 2022 Jun 180:106227 （中科院I区，IF=10.334）

  8. Peng Y, Liu H, Liu J, Long J*.Post-translational modifications on mitochondrial metabolic enzymes in cancer. Free Radic Biol Med. 2022 Feb 1;179:11-23. （中科院2区，IF=7.4）

  9. Peng Y, Liu J, Wang Z, Cui C, Zhang T, Zhang S, Gao P, Hou Z, Liu H, Guo J, Zhang J, Wen Y, Wei W, Zhang L*, Liu J*, Long J*. Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc. Cell Death Differ. 2022 Sep 29(9):1730-1743. （中科院1区，IF=15.828）

  10. Wang X, Lv W, Xu J, Zheng A, Zeng M, Cao K, Wang X, Cui Y, Li H, Yang M, Shao Y, Zhang F, Zou X, Long J, Feng Z*, Liu J*. Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits.  Adv  Sci (Weinh). 2022 Jan 17:e2105587. （中科院1区，IF=16.806）

2021

  1. Zeng M, Xu J, Zhang Z, Zou X, Wang X, Cao K, Lv W, Cui Y, Long J, Feng Z, Liu J. Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes. Redox Biol. 2021 May;41:101948. （中科院1区，IF=9.986）

  2. Cao K, Lv W, Wang X, Dong S, Liu X, Yang T, Xu J, Zeng M, Zou X, Zhao D, Ma Q, Lin M, Long J, Zang W, Gao F, Feng Z, Liu J. Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance. Adv Sci (Weinh). 2021 May 2;8(11):2004507.（IF=15.84，中科院1区）

  3. Liu R, Chen L, Wang Z, Zheng X, Hou Z, Zhao D, Long J, Liu J. Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis. J Nutr Biochem. 2021.88.（中科院2区，IF=4.873）

  4. Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, Pandolfi PP, Asara JM, Kaelin WG Jr, Liu J, Wei W. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Res. 2021 Jan;31(1):80-93. （中科院1区，IF=20.507）

  5. Lu Z, Hu Y, Wang Y, Zhang T, Long J*, Liu J. Topological reorganizations of mitochondria isolated from rat brain after 72 hours of paradoxical sleep deprivation, revealed by electron cryo-tomography. Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C17-C25（中科院2区，IF=4.25）

  6. Lu Z, Liu X, He M, Long J, Liu J. Dynamic motions and architectural changes in DNA supramolecular aggregates visualized via transmission electron microscopy without liquid cells. Nanoscale. 2021 Sep 15. （中科院1区，IF=6.895）
  7. Noda M, Liu J, Long J. Neuroprotective and preventative effects of molecular hydrogen. Curr Pharm Des. 2021 27(5) 585-591.（中科院3区，IF=2.208）

  8. Zhang T, Zhang S, Peng Y*, Wang Y, Gao P, Hu Y, Wang Z, Noda M, Hiramatsu M, Liu J, Long J*. Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice. Food Funct. 2021;12(22):11704-11716.（中科院1区，IF=5.396）

  9. Cui Y, Xiong Y, Li H, Zeng M, Wang Y, Li Y, Zou X, Lv W, Gao J, Cao R, Meng L, Long J, Liu J, Feng Z. Chalcone derived Nrf2 activator protects cognitive function via maintaining neuronal redox status. Antioxidants （Basel）. 2021, 10(11): 1811.（中科院2区，IF= 6.313）

  10. Lu Z, Hu Y, Wang Y, Zhang T, Long J*, Liu J. Topological reorganizations of mitochondria isolated from rat brain after 72 hours of paradoxical sleep deprivation, revealed by electron cryo-tomography. Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C17-C25. （中科院2区，IF=4.25）

2020

  1. Shi L, Du D, Peng Y, Liu J*, Long J*. The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer. Oncogenesis. 2020 Oct 31;9(10):98.（中科院2区，IF=6.119）
  2. Shi L, Liu J, Peng Y, Zhang J, Dai X, Zhang S, Wang Y, Liu J*, Long J*. Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Mol Oncol. 2020 Dec;14(12):3169-3183. （中科院2区，IF=6.574）
  3. Qin C, Hu S, Zhang S, Zhao D, Wang Y, Li H, Peng Y, Shi L, Xu X, Wang C, Liu J, Cheng Y*, Long J*. Hydroxytyrosol Acetate Improves the Cognitive Function of APP/PS1 Transgenic Mice in ERβ-dependent Manner. Mol Nutr Food Res. 2020 Dec 9:e2000797. （中科院1区，IF=5.309）
  4. Liu J, Peng Y, Zhang J, Long J, Liu J, Wei W. Targeting SCF E3 Ligases for Cancer Therapies. Adv Exp Med Biol. 2020 217:123-146. （中科院3区，IF=2.450）
  5. Liu R, Chen L, Wang Z, Zheng X, Hou Z, Zhao D, Long J, Liu J. Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis. J Nutr Biochem. 2020 Sep 19;88:108503. 
  6. Wang XP, Xing CY, Zhang JX, Zhou JH, Li YC, Yang HY, Zhang PF, Zhang W, Huang Y, Long J, Gao F, Zhang X, Li J. Time-restricted feeding alleviates cardiac dysfunction induced by simulated microgravity via restoring cardiac FGF21 signaling. FASEB J. 2020 Nov 34(11):15180-15196. 

  7. Peng Y,Gao P,Shi L,Chen L,Liu J,Long J*. Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention. Antioxid Redox Signal. 2020 32(16):1188-1236.  (comprehensive invited review)IF=7

  8. Liu J, Peng Y, Zhang J, Long J*, Liu J, Wei W.  Targeting SCF E3 Ligases for Cancer Therapies. Adv Exp Med Biol. 2020, 1217:123-146. IF=2.450
  9. Liu R, Chen L, Wang Z, Zheng X, Wang Y, Li H, Noda Mami, Liu J, Long J*. Downregulation of the DNA 5-hydroxymethylcytosine is involved in mitochondrial dysfunction and neuronal impairment in high fat diet-induced diabetic mice. Free Radic Biol Med. 2020 Feb 20;148:42-51. IF=6.170
  10. Shi L, Liu J, Peng Y, Zhang J, Dai X, Zhang S, Wang Y, Liu J, Long J*. Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Mol Oncol. 2020 14(12): 3169-3183. IF=6.574.
  11. Shi L, Du D, Peng Y, Liu J*, Long J*. The functional analysis of Cullin7 E3 ubiquitin ligases in cancer. Oncogenesis. 2020 9(10): 98. IF=7.845.

2019

  1. Zhao D, Zhang S, Wang X, Gao D, Liu J, Cao K, Chen L, Liu R, Liu J, Long J*.  ATG7 regulates hepatic Akt phosphorylation through the c-JUN/PTEN pathway in high fat diet-induced metabolic disorder. FASEB J. 2019 Dec 33(12):14296-14306. IF=4.966

2018

  1. Wang D, Meng L, Fei Z, Hou C, Long J*, Zeng L, Dyson Paul J, Huang P. Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity. Nanoscale. 2018 10(18).  IF=6.895
  2. Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long J, Li Z, Shen W, Liu J. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death Differ. 2018 25(2): 229. IF=8.339
  3. Ouyang C, Chen L, Rees TW, Chen Y, Liu J, Ji L, Long J*, Chao H*. A mitochondria-targeting hetero-binuclear Ir (III)-Pt (II) complex induces necrosis in cisplatin-resistant tumor cells. Chem Commun (Camb). 2018 Jun 14; 54(49):6268-6271. IF=6.319
  4. Hou C, Peng Y, Qin C, Fan F, Liu J, Long J*. Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance. Free Radic Res. 2018 Dec 52（11-12):1311-1312. IF=3.18
  5. Wang K, Xu Y, Sun Q, Long J, Liu J, Ding J. Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms. Free Radical Res. 2018 Dec 52(11-12):1256-1265. IF=3.18

2017

  1. Hou C, Wang Y, Liu J, Wang C, Long J*. Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.Front Mol Neurosci. 2017 Mar 21;10:66. IF 5.154
  2. Xie Z, Long J, Liu J, Chai Z, Kang X, Wang C. Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons. Front Mol Neurosci. 2017 Mar 13;10-47. IF 5.154
  3. Qing Y, Tian Z, Bi Y, Wang Y, Long J, Song CX, Diao J. Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine. Bioessays. 2017 May 39(5). IF 4.725
  4. Chen L, Liu L, Li C, Hu C, Su F, Liu R, Zeng M, Zhao D, Liu J, Guo Y*, Long J*. A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice. Mol Nutr Food Res. 2017 Mar 61(3). IF 4.551
  5. Shi L, Zhao D, Hou C, Peng Y, Liu J, Zhang S, Liu J, Long J*. Early interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65. Neurobiol Aging. 2017 Aug 56:115-126. IF 5.117
  6.  Lu Z, Li H, Hou C, Peng Y, Long J, Liu J. Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells. Eur Biophys J. 2017 Jul 46(5):415-424. IF 1.444
  7. Chen L, Liu L, Li C, Hu C, Su F, Liu R, Zeng M, Zhao D, Liu J, Guo Y, Long J*. A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice. Mol Nutr Food Res. 2017 Mar 1(3). IF 4.55.

2016

  1. Wang Y, Li L, Hou C, Lai Y, Long J, Liu J, Zhong Q, Diao J. SNARE-mediated membrane fusion in autophagy. Semin Cell Dev Biol. 2016 Dec;60:97-104. IF 5.181
  2. Peng Y, Hou C, Yang Z, Li C, Jia L, Liu J, Tang Y, Shi L, Li Y, Long J, Liu J. Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice. Mol Nutr Food Res. 2016 Nov 0(11):2331-2342. IF 4.551
  3. Yan C, Sun W, Wang X, Long J, Liu X, Feng Z, Liu J. Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res. 2016 May 60(5):1139-1149. IF 3.842
  4. Hu R, Diao J, Li J, Tang Z, Li X, Leitz J, Long J, Liu J, Yu D, Zhao Q. Intrinsic and membrane-facilitated α-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep. 2016 Feb 11;6:20776. IF 5.228
  5. Wang P, Jia L, Chen B, Zhang L, Liu J, Long J, Li Y. Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock. 2016 Sep 6(3):312-318. IF 3.048
  6. Huang H, Yang L, Zhang P, Qiu K, Huang J, Chen Y, Diao J, Liu J, Ji L, Long J*, Chao H*. Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes. Biomaterials. 2016 83: 321-331. IF 8.387
  7. Hou C, Wang Y, Zhu E, Yan C, Zhao L, Wang X, Qiu Y, Shen H, Sun X, Feng Z, Liu J, Long J*. Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol. 2016 Mar 1;103:85-97. IF 5.091
  8. Liu J, Peng Y, Wang X, Fan Y, Qin C, Shi L, Tang Y, Cao K, Li H, Long J, Liu J. Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling. Mol Pharm. 2016 Jan 4;13(1):73-84.  IF 4.384
  9. Tang Y, Peng Y, Liu J, Shi L, Wang Y, Long J, Liu J. Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE /PSEN1dE9 mouse model of Alzheimer's disease. J Neurochem. 2016 Feb136(4):791-803. IF 4.281

2015

  1. Tang Y, Liu J, Long J*. Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy. J Diabetes Investig. 2015 3, 250-255. IF 1.8
  2. Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y, Long J, Liu J, Feng Z. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr. 2015 111667-11176. IF 3.453
  3. Sun L, Liu T, Li H, Yang L, Meng L, Lu Q, Long J. Fluorescent and cross-linked organic-inorganic hybrid nanoshells for monitoring drug delivery. ACS Appl Mater Interfaces. 2015 8, 4990-4997. IF 6.723

2014

  1. Luo C, Li Y, Yang L, Zheng Y, Long J*, Jia J, Xiao S, Liu J. Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.Int J Nanomedicine. 2014 9,4763-4772. IF 4.383
  2. Zou X, Yan C, Shi Y, Cao K, Xu J, Wang X, Chen C, Luo C, Li Y, Gao J, Pang W, Zhao J, Zhao F, Li H, Zheng A, Sun W, Long J, Szeto IM, Zhao Y, Dong Z, Zhang P, Wang J, Lu W, Zhang Y, Liu J, Feng Z. Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 2014 Oct 10 21(11):1557-1570. IF 7.67
  3. Zhao L, Zou X, Feng Z, Luo C, Liu J, Li H, Chang L, Wang H, Li Y, Long J, Gao F, Liu J. Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol. 2014 Aug 56:3-12. IF 3.53
  4. Tang Y, Mi C, Liu J, Gao F, Long J. Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Cardiovasc Pathol. 2014 Mar-Apr 23(2):101-106. IF 2.4
  5. Peng Y, Liu J, Tang Y, Liu J, Han T, Han S, Li H, Hou C, Liu J, Long J. High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AβPP Processing and Cognition in Female APP/PS1 Mice. Front Cell Neurosci. 2014 Aug 8;8:225. IF 4.18
  6. Luo C, Li Y, Zhou B, Yang L, Li H, Feng Z, Li Y, Long J, Liu J. A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells. Apoptosis. 2014 Mar 19(3):542-553. IF 3.61
  7. Luo C, Li Y, Yang L, Zheng Y, Long J, Jia J, Xiao S, Liu J. Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts. Int J Nanomedicine. 2014 Oct 10;9:4763-4772. IF 4.20
  8. Luo C, Li Y, Yang L, Wang X, Long J, Liu J. Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses. Arch Toxicol. 2015 Mar 89(3):357-569. IF 5.1
  9. Liu Y, Long J, Liu J. Mitochondrial free radical theory of aging: who moved my premise? Geriatr Gerontol Int. 2014 Oct 14(4):740-749. IF 1.58
  10. Liu J, Tang Y, Feng Z, Liu J, Liu J, Long J. (-)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto-Kakizaki rats. Free Radic Res. 2014 Aug 48(8):898-906. IF 3.00
  11. Liu J, Tang Y, Feng Z, Hou C, Wang H, Yan J, Liu J, Shen W, Zang W, Liu J, Long J. Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism. 2014 Oct 3(10):1314-1323. IF 3.61
  12. Liu J, Peng Y, Feng Z, Shi W, Qu L, Li Y, Liu J, Long J. Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radic Biol Med. 2014 Apr 69:116-128. IF 5.71
  13. Chen C, Han X, Zou X, Li Y, Yang L, Cao K, Xu J, Long J, Liu J, Feng Z. 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem. 2014 Jun 13;289(24):17184-17194. IF 4.6
  14. Chang L, Liu X, Liu J, Li H, Yang Y, Liu J, Guo Z, Xiao K, Zhang C, Liu J, Zhao-Wilson X, Long J. D-galactose induces a mitochondrial complex I deficiency in mouse skeletal muscle: potential benefits of nutrient combination in ameliorating muscle impairment. J Med Food. 2014 Mar 7(3):357-364. IF 2.5
  15. Cao K, Zheng A, Xu J, Li H, Liu J, Peng Y, Long J, Zou X, Li Y, Chen C, Liu J, Feng Z. AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med. 2014 Oct 75:156-166. IF 5.71
  16. Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Li H, Szeto IM, Shi Y, Long J, Liu J, Feng Z. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2014 Feb 7:396-407. IF 5.71

2013

  1. Luo C, Wang H, Chen X, Cui Y, Li H, Long J, Mo X, Liu J. Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae. Phytomedicine. 2013 21, 20-24. IF 3.3
  2. Luo C, Li Y, Yang L, Feng Z, Long J, Liu J. A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology. 2013 14, 503-511. IF 3.2
  3. Luo C, Li Y, Wang H, Feng Z, Long J*, Liu J. Mitochondrial accumulation under oxidative stress is due to defects in autophagy. J Cell Biochem. 2013 114, 212-219. IF 3.4
  4. Luo C, Li Y, Wang H, Cui Y, Feng Z, Li H, Wang Y, Wurtz K, Weber P, Long J*, Liu J. Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells. Curr Cancer Drug Targets. 2013 13, 625-639. IF 4.3
  5. Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Szeto IM, Shi Y, Long J, Liu J, Feng Z. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2013 67C, 396-407. IF 5.3
  6. Aksenov V, Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD. A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice. Age (Dordr). 2013 35, 23-33. IF 6.2

2012

  1. Yan J, Feng Z, Liu J, Shen W, Wang Y, Wertz K, Weber P, Long J*, Liu J. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. J Nutr Biochem. 2012 23, 716-724. IF 4.2
  2. Long J, He P, Shen Y, Li R. New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-beta. J Alzheimers Dis. 2012 30, 545-558. IF 4.2
  3. Long J, Gao M, Kong Y, Shen X, Du X, Son YO, Shi X, Liu J, Mo X. Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine. 2012 19, 672-676. IF 3.3
  4. Long J, Aksenov V, Rollo CD, Liu J. A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging. Mech Ageing Dev. 2012 Aug 133(8):523-9. IF 4.2
  5. Liu J, Peng Y, Long J*. The Role of Brain Mitochondrial Estrogen Receptor beta in The Pathogensis of Female Alzheimer's Disease. Progress In Biochemistry And Biophysics. 2012 785-790. IF 0.5
  6. Liu J, Peng Y, Cui Z, Wu Z, Qian A, Shang P, Qu L, Li Y, Long J*. Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading. IUBMB Life. 2012 64(11):901-10. IF 3.8

2011

  1.  Hao J, Shen W, Sun L, Long J, Sharman E, Shi X, Liu J. Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats: improvement by a combination of nutrients. Br J Nutr. 2011 106, 648-655. IF 3.2
  2. Gao M, Li Y, Sun Y, Shah W, Yang S, Wang Y, Long J* . Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix. Basic Clin Pharmacol Toxicol. 2011 109, 398-406. IF 2.3
  3. Gao M, Li Y, Sun Y, Long J, Kong Y, Yang S, Wang Y. A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage. Mutat Res. 2011 724, 69-75. IF 3.2
  4. Gao M, Li Y, Long J, Shah W, Fu L, Lai B, Wang Y. Induction of oxidative stress and DNA damage in cervix in acute treatment with benzo[a]pyrene. Mutat Res. 2011 719, 52-59. IF 3.2

2010

  1. McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R. Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. J Neurosci. 2010 30, 7326-7334. IF 7.2
  2. Gao M, Long J, Li Y, Shah W, Fu L, Liu J, Wang Y. Mitochondrial decay is involved in BaP-induced cervical damage. Free Radic Biol Med. 2010 49, 1735-1745. IF 5.7
  3. Aldarmaa J, Liu Z, Long J, Mo X, Ma J, Liu J. Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem Res. 2010 35, 33-41. IF 2.7
  4. Aksenov V, Long J, Lokuge S, Foster JA, Liu J, Rollo CD. Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Exp Biol Med (Maywood). 2010 235, 66-76. IF 2.7

2010...

  1. Long J, Ma J, Luo C, Mo X, Sun L, Zang W, Liu J. Comparison of two methods for assaying complex I activity in mitochondria isolated from rat liver, brain and heart. Life Sci. 2009 85, 276-280. IF 2.5
  2. Long J, Liu C, Sun L, Gao H, Liu J. Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem Res. 2009 34, 786-794. IF 2.7
  3. Long J, Gao H, Sun L, Liu J, Zhao-Wilson X. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Res. 2009 12, 321-331. IF 4.1
  4. Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009 34, 755-763. IF 2.7
  5. Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, Long J, Sharman E, Liu J. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med. 2009 13, 701-711. IF 4.6
  6. Luo C, Long J, Liu J. An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity. Clin Chim Acta. 2008 395, 38-41. IF 2.85
  7. Long J, Liu C, Sun L, Gao H, Liu J. Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria. Neurochem Res. 2009 34(4):786-94. IF 2.1
  8. Shen H, Zhang Y, Xu J, Long J, Qin H, Liu F, Guo J. Zinc distribution and expression pattern of ZnT3 in mouse brain. Biol Trace Elem Res. 2007 119, 166-174. IF 1.5
  9. Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Cui X, Packer L, Liu J. D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology. 2007 8, 373-381. IF 3.0
  10.  Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, Wang Y, Weber P, Long J, Liu J. Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem. 2007 103, 2690-2700. IF 4.1
  11. Sun L, Luo C, Long J, Wei D, Liu J. Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion. 2006 6, 136-142. IF 3.7
  12. Luo C, Wang X, Long J, Liu J. An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates. J Biochem Biophys Methods. 2006 68, 101-111. IF 2.2
  13.  Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Liu J. Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Life Sci. 2006 79, 1466-1472. IF 2.5
  14. Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J, Packer L, Liu J. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res. 2006 83, 1584-1590. IF 2.9