Projects

  1. 国家自然科学基金青年项目，51903203，结题，主持；
  2. 中国博士后面上项目，2019M653661，结题，主持；
  3. 陕西省自然科学基础研究计划-一般项目（面上），2024JC-YBMS-272，在研，主持；
  4. 陕西省博士后科研项目，2023BSHYDZZ05，在研，主持；
  5. 基本科研业务费自由探索与创新项目，xzy012022037，在研，主持；
  6. 陕西省自然科学基础研究计划-一般项目（青年），2020JQ-046，结题，主持；
  7. 陕西省中医药管理局，秦创原中药创新研发项目，2022-QCYZH-017，在研，合作单位主持；

Publication

Publications with XJTU (arrange in chronological order):

  1. Zhe Yang, Di Gao (Co-first author), Jing Zhao, Gaojie Yang, Ming Guo, Ying Wang, Xuechun Ren, Kim Jong Seung, Lin Jin, Zhongmin Tian, Xingcai Zhang. Thermal-immuno-nanomedicine in cancer. Nature Reviews Clinical Oncology, 2023, 20, 116-134.  (Cover, ESI高被引论文)
  2. Liangliang Jia, Ye Hong, Xinyu He, Ying Zhou, Liujiao Ren, Hongjun Du, Bin Zhao, Bin Qin*, Zhe Yang*, Di Gao* (Corresponding  author). Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2024, 109957.
  3. Ye Hong, Di Gao (co-first author), Bin Zhao, Jinlu Ma, Zhe Yang, Hui Guo. Thermal immuno-nanomedicine: A new strategy for cancer treatment. Clinical and Translational Medicine, 2023, 13, e1256.
  4. Di Gao, Yupeng Shi, Jiahua Ni, Shuojia Chen, Ying Wang, Bin Zhao, Manli Song, Xiaoqing Guo, Xuechun Ren, Xingcai Zhang, Zhongmin Tian, and Zhe Yang. NIR/MRI-guided oxygen-independent carrier-free anti-tumor nano-theranostics. Small, 2022, 2106000.
  5. Ying Wang, Di Gao (Co-first author), Lin Jin, Xuechun Ren, Yanan Ouyang, Ying Zhou,  Xinyu He, Liangliang Jia, Zhongmin Tian, Dingcai Wu, Zhe Yang. NADPH selective depletion nanomedicine-mediated radio-immunometabolism regulation for strengthening anti-PDL1 therapy against TNBC. Advanced Science, 2022, 202203788.
  6. Bin Zhao , Sa Chen, Ye Hong, Liangliang Jia, Ying Zhou, Xinyu He, Ying Wang, Zhongmin Tian, Zhe Yang*, Di Gao*(Corresponding author). Research progress of conjugated nanomedicine for cancer treatment. Pharmaceutics, 2022, 14, 1522.
  7. Xuechun Ren, Ying Wang, Liangliang Jia, Xiaoqing Guo, Xinyu He, Zhipeng Zhao*, Di Gao*(Co-corresponding author), Zhe Yang*. Intelligent nanomedicine approaches using medical gas-mediated multi-therapeutic modalities against cancer. Journal of Biomedical Nanotechnology, 2022, 18, 24-49.
  8. Di Gao, Ting Chen, Shuojia Chen, Xuechun Ren, Yulong Han, Yiwei Li, Ying Wang, Xiaoqing Guo, Hao Wang, Xing Chen, Ming Guo, Yu Shrike Zhang, Guosong Hong, Xingcai Zhang, Zhongmin Tian, Zhe Yang. Targeting Hypoxic tumors with hybrid nanobullets for oxygen-independent synergistic photothermal and thermodynamic therapy. Nano-micro Letters, 2021, 13(1), 99. (Cover, 2022年曾入选ESI高被引论文)
  9. Di Gao, Roy C. H. Wong, Ying Wang, Xiaoqing Guo, Zhe Yang, Pui-Chi Lo. Shifting the absorption to the near-infrared region and inducing a strong photothermal effect by encapsulating zinc(II) phthalocyanine in poly(lactic-co-glycolic acid)-hyaluronic acid nanoparticles. Acta Biomaterialia, 2020, 116, 329-343.
  10. Ying Wang, Di Gao (Co-first author), Yan Liu, Xiaoqing Guo, Shuojia Chen, Li Zeng, Jinxuan Ma, Xingcai Zhang, Zhongmin Tian, Zhe Yang. Immunogenic-cell-killing and Immunosuppression-inhibiting Nanomedicine. Bioactive Materials, 2020, 6, 1513-1527. (2022年曾入选ESI高被引论文)
  11. Di Gao, Xiaoqing Guo, Xingcai Zhang, Shuojia Chen, Ying Wang, Ting Chen, Gang Huang, Yanzheng Gao, Zhongmin Tian, Zhe Yang. Multifunctional phototheranostic nanomedicine for cancer imaging and treatment. Materials Today Bio, 2020, 5, 100035. (ESI高被引论文)
  12. Zhe Yang, Di Gao, Xiaoqing Guo, Lin Jin, Juanjuan Zheng, Ying Wang, Shuojia Chen, Xuewei Zheng, Li Zeng, Ming Guo, Xingcai Zhan*, Zhongmin Tian*. Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged nanobullets. ACS Nano, 2020, 14, 17442-17457. （ESI热点论文）

Publications prior XJTU (arrange in chronological order):

  1. Di Gao, Pui-chi Lo. Combined pH-responsive chemotherapy and glutathione-triggered photosensitization to overcome drug-resistant hepatocellular carcinoma. Journal of Porphyrins and Phthalocyanines, 2020, 24, 1387-1401.
  2. Di Gao, Pui-chi Lo. Polymeric micelles encapsulating pH-responsive doxorubicin prodrug and glut- athione-activated zinc(II) phthalocyanine for combined chemotherapy and photodynamic therapy. Journal of Controlled Release, 2018, 282, 46-61. 
  3. Di Gao, Jinbiao Gao, Ming Xu, Zhong Cao, Luyao Zhou, Yingqin Li, Xiaoyan Xie, Qing Jiang, Wei Wang, Jie Liu. Targeted ultrasound-triggered phase transition nanodroplets for Her2-overexpressing breast cancer diagnosis and gene transfection. Molecular Pharmaceutics, 2017, 14, 984-998.
  4. Di Gao, Ming Xu, Zhong Cao, Jinbiao Gao, Ya Chen, Yingqin Li, Zhe Yang, Xiaoyan Xie, Qing Jiang, Wei Wang, Jie Liu. Ultrasound-triggered phase-transition cationic nanodroplets for enhanced gene delivery. ACS Applied Materials & Interfaces, 2015, 7, 13524-13537.
  5. Zhe Yang, Di Gao (co-first author), Zhong Cao, Chao Zhang, Du Cheng, Jie Liu, Xintao Shuai. Drug and gene co-delivery systems for cancer treatment. Biomaterials Science, 2015, 3, 1035-1049.

Patent

  1. 杨哲； 王颖； 高迪；一种可特异性清除NADPH的聚合物、多功能纳米药物及制备方法和应用， 2023-05-16， 中国，CN202210825910.8
  2. 杨哲；郭晓晴；高迪；王颖； 一种携氧仿生纳米解毒剂及其制备方法和应用，2022-05-20，中国，CN202110730543.9
  3. 刘杰； 蒋庆；高迪；陈可欣；余柏青； 一种阳离子聚氨基酸基因载体材料及其制备方法， 2016-04-20，中国，CN201410013791.1
  4. 刘杰； 蒋庆； 罗新根； 舒雅俊；高迪；一种包载可生物降解纳米粒的口服结肠靶向微囊及其制备方法，2015-03-04，中国, CN201310340081.5