2024年

 

[60] Feng Chen*, et. al. Preadenylation-free termini modification-independent smRNA sequencing. 

[59] Feng Chen*, et. al. DNA framework proximity encoder for differentiated visualization of cell surface RNA and glycoRNA in neurons. 

[58] Feng Chen*, et. al. Molecular differentiation by orthogonal tandem repeat DNA identifiers to dissect dense glycoRNAs in nanoenvironments. 

[57] Feng Chen*, et. al. ABC-seq expands small RNAs content with randomized adapter pools operation. Nature Methods, under review. 

[56] Feng Chen*, et. al. DNA-assisted separation of nanoparticles. Small Methods, under review. 

[55] Feng Chen*, et. al. DNA-encoded fluorescence signals for imaging analysis. Small Methods, under review. 

[54] Feng Chen, Xinyin Li, Min Bai, and Yongxi Zhao*. Visualizing epigenetic modifications and their spatial proximities in single cells using three DNA-encoded amplifying FISH imaging strategies: BEA-FISH, PPDA-FISH and Cell-TALKING. Nature Protocols, 2024. (IF 13.1)

 2023年

[53] Wanchuan Ding, Xuan Yang, Huoyue Lin, Zixing Xu, Jun Wang, Jie Dai, Can Xu, Feng Chen, Xiaowei Wen*, Weiran Chai*, and Gang Ruan*. Mechanism-Driven Technology Development for Solving the Intracellular Delivery Problem of Hard-To-Transfect Cells. Nano Letter, 2023, https://doi.org/ 10.1021/acs.nanolett.2c04834. (IF )

[52] Xiaowen Cao, Feng Chen*, Jing Xue, Yue Zhao, Min Bai and Yongxi Zhao*. Hierarchical DNA branch assembly-encoded fluorescent nanoladders for single-cell transcripts imaging. Nucleic Acids Research, 2023, DOI: https://doi.org/10.1093/nar/gkac1138 (IF 19.160)

 

 2022年

[51] Jing Xue, Youlan Fu, Siyue Fan, Xiaowen Cao, Wei Huang, Jin Zhang, Yongxi Zhao and Feng Chen*. Branched immunochip-integrated pairwise barcoding amplification exploring the spatial proximity of two post-translational modifications in distinct cell subpopulations. Chemical Communications, 2022, 58, 10020-10023. (IF 6.065) 

[50] Feng Chen#, Jing Xue#, Min Bai, Chunhai Fan and Yongxi Zhao*. Lighting up Nucleic Acid Modifications in Single Cells with DNA-Encoded Amplification. Accounts of Chemical Research, 2022, 55, 2248-2259. (IF 24.466) 

[49] Fengjiao Zhao^#, FengChen^#, Huahang Yu, Siyue Fan, Min Bai, Jing Xue, Yue Zhao, Xiaolei Zuo, Chunhai Fan and Yongxi Zhao*. CRISPR/Cas system-guided plasmid mutagenesis without sequence restriction. Fundamental Research, DOI: https://doi.org/10.1016/j.fmre.2022.06.017 

[48] Xiaoxing Fang^#, Yue Zhao^#, Min Bai, Feng Chen, Biwu Liu and Yongxi Zhao*. Hydrogel-compartmentalized heterogeneous amplification for viral digital genotyping. Sensors and Actuators B: Chemical, 2022, 356, 131339 (IF 7.460)

[47]  Li Su^#, Fengjiao Zhao^#, Huahang Yu, Min Bai, Jing Xue, Xiaowen Cao, Feng Chen and Yongxi Zhao*. A bifunctional chemical signature enabling RNA 4-thiouridine enrichment sequencing with single-base resolution. Chemical Communications, 2022, 58, 1322-1325 (IF 6.222)

2021年

[46] Li Su^#, Feng Chen^#, Huahang Yu, Hao Yan, Fengjiao Zhao, Chunhai Fan, and  Yongxi Zhao*. Addition–Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling. Analytical Chemistry, 2021, 93, 13974-13980 (IF 6.896)

[45]  Min Bai, Xiaowen Cao, Feng Chen, Jing Xue, Yue Zhao, and Yongxi Zhao*. Bioorthogonal Chemical Signature Enabling Amplified Visualization of Cellular Oxidative Thymines. Analytical Chemistry, 2021, 93, 10495–10501 (IF 6.896)

[44]  Feng Chen^#, Min Bai^#, Xiaowen Cao, Jing Xue, Yue Zhao, Na Wu, Lei Zhang, Dexin Zhang, and Yongxi Zhao*. Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications. Nature Communications, 2021, 12, 1965. (IF 12.121) https://www.nature.com/articles/s41467-021-22284-z

Selected as Research Highlight by Nature Methods.

Walking through chromatin modifications. Nature Methods, 2021, 18: 446.

https://www.nature.com/articles/s41592-021-01159-7

2020年

[43] Yongxi Zhao, Xiaolei Zuo, Qian Li, Feng Chen,,,,,,,,,, Chaoyong Yang, Xiaobing Zhang, Huanghao Yang, Weihong Tan, Chunhai Fan. Nucleic Acids Analysis. SCIENCE CHINA Chemistry, 2020, 10.1007/s11426-020-9864-7 (IF 6.356)

[42] Jing Xue, Feng Chen, Min Bai, Xiaowen Cao,Wenhao Fu, Jin Zhang, and Yongxi Zhao*. Aptamer-Functionalized Microdevices for Bioanalysis. ACS Applied Materials & Interfaces, 2020, 10.1021/acsami.0c16138 (IF 8.758)

[41] Jing Xue^#, Feng Chen^#, Li Su^#, Xiaowen Cao, Min Bai, Yue Zhao, Chunhai Fan, and Yongxi Zhao*. Pairwise Proximity-differentiated Visualization of Single-cell DNA Epigenetic Marks. Angewandte Chemie International Edition, 2020, 10.1002/anie.202011172 (IF 12.959)

[40] Xiaowen Cao, Huahang Yu, Jing Xue, Min Bai, Yue Zhao, Youjun Li, Yongxi Zhao and  Feng Chen*. RNA-primed Amplification for Noise-suppressed Visualization of Single-cell Splice Variants. Analytical Chemistry, 2020, 92, 13, 9356-9361. (IF 6.350)

[39] Min Bai, Xiaowen Cao, Wei Huang, Feng Chen, Yue Zhao, Jing Xue, Youjun Li, Yilong Cheng, Lei Zhang, and Yongxi Zhao*. Visualizing Newly Synthesized RNA by Bioorthogonal Labeling-primed DNA Amplification. Analytical Chemistry, 2020, 92, 12, 8444–8449. (IF 6.350)

[38] Min Bai^#, Feng Chen^#, Xiaowen Cao, Yue Zhao, Jing Xue, Xu Yu, Chunhai Fan, and Yongxi Zhao*. Intracellular Entropy-driven Multi-bit DNA Computing for Tumor Progression Discrimination. Angewandte Chemie International Edition, DOI: 10.1002/anie.202001598 (IF 12.257)

Highlighted by

国家自然科学基金委员会,http://www.nsfc.gov.cn/csc/20340/20343/53227/index.html

[37] Feng Chen#, Jing Xue#, Jin Zhang, Min Bai, Xu Yu, Chunhai Fan and Yongxi Zhao*. Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding. Journal of the American Chemical Society, 2020, 142, 6, 2889-2896. (IF 14.695)

Highlighted by

科技日报http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2020-03/16/content_441516.htm?div=-1

2019年

[36] Feng Chen^#, Min Bai^#, Xiaowen Cao, Yue Zhao, Jing Xue, and Yongxi Zhao*. Click-encoded rolling FISH for visualizing single-cell RNA polyadenylation and structures. Nucleic Acids Research, 2019, 47, 22, e145. (IF 11.157) 

[35] Yue Zhao, Xiaoxing Fang, Feng Chen, Min Bai, Chunhai Fan, Yongxi Zhao*. Locus-patterned sequence oriented enrichment for multidimensional gene analysis. Chemical Science, 2019, 10, 8421-8427.(IF 9.556)

[34] Yu Xu, Na Wu, Feng Chen, Jing Wei, Yongxi Zhao*. Engineering Microfluidic chip for Circulating Tumor Cells: From Enrichment, Release to Single Cell Analysis. Trends in Analytical Chemistry, DOI: 10.1016/j.trac.2019.03.027 (IF 8.428)

[33] Jing Xue^#, Feng Chen^#, Min Bai, Xiaowen Cao, Ping Huang,  and Yongxi Zhao*. All-in-one Synchronized DNA Nanodevices Facilitating Multiplexed Cell Imaging. Analytical Chemistry, 2019, 91, 7, 4696-4701. (IF 6.042) 

[32] Feng Chen^#, Jing Xue^#, Min Bai, Jing Qin,  and Yongxi Zhao*. Programming in situ accelerated DNA walkers in diffusion-limited microenvironments. Chemical Science, 2019, 10，3103-3109 (IF 9.063) 

2018年

[31] Na Wu, Feng Chen, Yue Zhao, Yu Xu, Jing Wei and Yongxi Zhao*. Functional and Biomimetic DNA Nanostructures on Lipid Membranes. Langmuir,  2018, 34(49), 14721-14730 (IF 3.789) 

[30] Dongzhen Chen, Xiaodong Zhu, Jian Huang, Gen Wang, Yue Zhao, Feng Chen, Jing Wei, Zhongxiao Song, and  Yongxi Zhao*. Polydopamine @ Gold Nanowaxberry Enabling Improved SERS Sensing of Pesticides, Pollutants and Explosives in Complex Samples. Analytical Chemistry, 2018, 90, 9048−9054(IF 6.042)

[29] Jing Wei^#, Gen Wang^#, Feng Chen^#, Min Bai, Yan Liang, Huanting Wang, Dongyuan Zhao,  Yongxi Zhao*. Sol-gel Synthesis of Metal-Phenolic Coordination Spheres and Their Derived Carbon Composites. Angewandte Chemie International Edition, 2018, 57, 9838 –9843 (IF 12.102)

[28] Feng Chen^#, Min Bai^#, Yue Zhao, Ke Cao, Xiaowen Cao and Yongxi Zhao*. MnO₂-Nanosheet-Powered Protective Janus DNA Nanomachines Supporting Robust RNA Imaging. Analytical Chemistry, 2018, DOI: 10.1021/acs.analchem.7b04634.

2017年

[27] Yue Zhao, Feng Chen, Jing Qin, Jing Wei, Wenhua Wu and Yongxi Zhao*.Engineered Janus probes modulating nucleic acid amplification to expand dynamic range for viral genome direct detection in one microliter crude serum samples. Chemical Science,  2018, 9: 392-397. (IF 8.668)PDF  

 

 

[26] Feng Chen^#, Min Bai^#, Ke Cao, Yue Zhao, Xiaowen Cao, Jing Wei, Na Wu, Jiang Li, Lihua Wang, Chunhai Fan, and Yongxi Zhao* .Programming Enzyme-Initiated Autonomous DNAzyme Nanodevices in Living Cells. ACS Nano, 2017, 11: 11908-11914. (IF 13.942)  PDF

[25] Min Bai, Xiaowen Cao, Feng Chen, Yue Zhao, Yongxi Zhao*. A FRET Ratiometric Probe Based on Quantum Dot-Cresyl Violet for Imaging Hydrogen Sulfide in Living Cells. Chinese Journal of Analytical Chemistry. (IF 0.795) Accepted.

 

[24] Feng Chen, Min Bai, Ke Cao, Yue Zhao, Jing Wei, Yongxi Zhao*. Fabricating MnO₂ Nanozymes as Intracellular Catalytic DNA Circuit Generators for Versatile Imaging of  Base-Excision Repair in Living Cell.Advanced Functional Materials, 2017, 27, 1702748 (IF 12.124) PDF  

[23] Feng Chen^#, Xuyao Wang^#, Xiaowen Cao , Yongxi Zhao*.  Accurate Electrochemistry Analysis of Circulation Methylated DNA from Clinical Plasma Based on Paired-End Tagging and Amplifications. Analytical Chemistry, 2017, 89: 10468-10473. (IF 6.320) PDF

 

[22] Jing Xue, Feng Chen, Min Bai, Xu Yu, Jing Wei, Ping Huang, Yongxi Zhao*.  DNA-Mediated Assembly of Gold Nanoparticles and Its Applications in Bioanalysis. ChemNanoMat,  2017, 3: 725-735.(IF 2.937)  PDF 

 

[21] Xuyao Wang^#, Feng Chen^#, Dexin Zhang, Yue Zhao, Jing Wei, Lihua Wang, Shiping Song, Chunhai Fan, Yongxi Zhao*. Single copy-sensitive electrochemical assay for circulating methylated DNA in clinical samples with ultrahigh specificity based on a sequential discrimination-amplification strategy. Chemical Science, 2017, 8: 4764-4770. (IF 8.668) PDF（Outside Back Cover） 

 

[20] Jian Huang^#, Dayan Ma^#, Feng Chen, Dongzhen Chen, Min Bai, Kewei Xu, Yongxi Zhao* . Green in Situ Synthesis of Clean 3D Chestnut-Like Ag/WO_3-x Nanostructures for Highly Efficient, Recyclable and Sensitive SERS Sensing. ACS Applied Materials & Interfaces, 2017, 9: 7436-7446. (IF 7.504).    PDF

 

2016 年

[19] Yue Zhao, Huaqing Liu, Feng Chen, Min Bai, Yongxi Zhao*. Fidelity quantification of mercury(II) ion via circumventing biothiols-induced sequestration in enzymatic amplification system. RSC Advances, 2016, 6: 80296-80301.  (IF 3.108)  PDF 

 

[18] Yue Zhao, Huaqing Liu, Feng Chen, Min Bai, Junwu Zhao*,Yongxi Zhao*. Trifunctional Molecular Beacon-Mediated Quadratic Amplification for Highly Sensitive and Rapid Detection of Mercury(II) Ion with Tunable Dynamic Range. Biosensors and Bioelectronics, 2016, 86: 892-898. (IF 7.78)  PDF

[17] Dongzhen Chen, Zhongxiao Song, Feng Chen, Jian Huang, Jing Wei, Yongxi Zhao*. Simply Controllable Growth of Single Crystal Plasmonic Au-Ag Nano-spines with Anisotropic Multiple Site for Highly Sensitive and Uniform Surface-Enhanced Raman Scattering Sensing. RSC Advances, 2016, 6: 66056-66065.  (IF 3.108)  PDF     

 

[16] Feng Chen^#, Manli Lin^#, Yue Zhao, Yongxi Zhao*. Catalase-functionalized SiO₂ nanoparticles mediate growth of gold nanoparticles for plasmonic biosensing of attomolar microRNA with the naked eye. RSC Advances, 2016, 6: 15709-15715. (IF 3.108) PDF    

[15] Feng Chen, Dexin Zhang, Qing Zhang, Xiaolei Zuo, Chunhai Fan, Yongxi Zhao*. Zero-background helicase-dependent amplification and its application to reliable assay of telomerase activity in cancer cell by eliminating primer-dimer artifacts. ChemBioChem, 2016, 17: 1171-1176. (IF 2.847) PDF  

 

2015年

 

[14] Yongxi Zhao*, Feng Chen, Qian Li, Lihua Wang, Chunhai Fan*.Isothermal amplification of nucleic acids.Chemical Reviews, 2015 , 115: 12491-12545. (IF 47.928) PDF 

 

[13] Jian Huang^#, Dayan Ma^#, Feng Chen, Min Bai, Kewei Xu,Yongxi Zhao*. Ag nanoparticles decorated cactus-like Ag dendrites/Si nanoneedles as highly efficient 3D SERS substrates toward sensitive sensing. Analytical Chemistry, 2015, 87: 10527-10534. (IF 6.32) PDF

[12] Feng Chen, Chunhai Fan,Yongxi Zhaoo*. Inhibitory impact of 3′-terminal 2′-O-methylated small silencing RNA on target-primed polymerization and unbiased amplified quantification of the RNA in arabidopsis thaliana. Analytical Chemistry, 2015, 87: 8758-8764.(IF 6.32) PDF

 

[11] Feng Chen,Yue Zhao,Chunhai Fan,Yongxi Zhao*. Mismatch extension of DNA polymerases and high-accuracy single nucleotide polymorphism diagnostics by gold nanoparticle-improved isothermal amplification. Analytical Chemistry, 2015, 87: 8718-8723.(IF 6.32)PDF 

 

 

[10] Jian Huang, Feng Chen, Qing Zhang, Yonghua Zhan, Dayan Ma*, Kewei Xu*, Yongxi Zhaoo*. 3D silver nanoparticles decorated zinc oxide/silicon heterostructured nanomace arrays as high-performance surface-enhanced raman scattering substrates. ACS Applied Materials & Interfaces, 2015,7: 5725-5735.(IF 7.105) PDF

 

2014年 

[9] Yongxi Zhao*, Feng Chen, Qing Zhang, Yue Zhao, Xiaolei Zuo, Chunhai Fan*. Polymerase/nicking enzyme synergetic isothermal quadratic DNA machine and its application for one-step amplified biosensing of lead (II) ions at femtomole level and DNA methyltransferase.NPG Asia Materials,2014,6:e131.(IF 9.157) PDF

[8] Qing Zhang^#, Feng Chen^#, Feng Xu, Yongxi Zhao*, Chunhai Fan. Target-triggered three-way junction structure and polymerase/nicking enzyme synergetic isothermal quadratic DNA machine for highly specific, one-step, and rapid microRNA detection at attomolar level. Analytical Chemistry,2014, 86 (16):8098-8105.(IF 6.32) PDF

 

[7] Yongxi Zhao*, Feng Chen, Manli Lin, Chunhai Fan. A methylation-blocked cascade amplification strategy for label-free colorimetric detection of DNA methyltransferase activity. Biosensors and Bioelectronics,2014,54:565-570.(IF 7.78) PDF 

 

[6] Yongxi Zhao*, Feng Chen, Yayan Wu, Yanhua Dong, Chunhai Fan. Highly sensitive fluorescence assay of DNA methyltransferase activity via methylation-sensitive cleavage coupled with nicking enzyme-assisted signal amplification. Biosensors and Bioelectronics, 2013,42:56-61. (IF 7.78) PDF 

 

2013年

[5] Yongxi Zhao*, Lin Qi, Feng Chen, Yue Zhao, Chunhai Fan. Highly sensitive detection of telomerase activity in tumor cells by cascade isothermal signal amplification based on three-way junction and base-stacking hybridization. Biosensors and Bioelectronics, 2013,41:764-770.(IF 7.78) PDF

 

[4] Feng Chen, Yongxi Zhao*, Lin Qi, Chunhai Fan. One-step highly sensitive florescence detection of T4 polynucleotide kinase activity and biological small molecules by ligation-nicking coupled reaction-mediated signal amplification. Biosensors and Bioelectronics, 2013,47:218-224. (IF 7.78) PDF

 

[3] Feng Chen, Yongxi Zhao*. Methylation-blocked enzymatic recycling amplification for highly sensitive fluorescence sensing of DNA methyltransferase activity. Analyst,2013,138:284-289.(IF 3.885) PDF

 

2012年

 

 

[2] Yongxi Zhao*, Lin Qi, Feng Chen,Yanhua Dong, Yu Kong,Yayan Wu, Chunhai Fan*. Ultrasensitive and selective detection of nicotinamide adenine dinucleotide by target-triggered ligation-rolling circle amplification. Chemical Communications,2012, 48:3354-3356. (IF 6.319) PDF

 

 

[1] Lin Qi, Yongxi Zhao*, Hui Yuan, Kai Bai,Yue Zhao, Feng Chen,Yanhua Dong,Yayan Wu. Amplified fluorescence detection of mercury(II) ions(Hg²⁺) using target-induced DNAzyme cascade with catalytic and molecular beacons. Analyst, 2012, 137:2799-2805. (IF 3.885) PDF