Zhihui Feng
Professor, Ph.D.
Center for Mitochondrial Biology and Medicine
Sochool of Life Science and Technology
Frontier Institute of Science and Technology
Xi'an Jiaotong University
Zhihui Feng
Professor, Ph.D.
Center for Mitochondrial Biology and Medicine
Sochool of Life Science and Technology
Frontier Institute of Science and Technology
Xi'an Jiaotong University
Tel: 029-82665849
Email: zhfeng@xjtu.edu.cn
Address: Rm #304,
School of Life Sci & Tech
No. 28 West Xianning Rd, Xi'an
710049, China.
2008-2012, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences,
Chinese Acadey of Sciences.
Ph.D. Majoring in Biochemistry and Molecular Biology
2006-2008, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences,
Chinese Acadey of Sciences.
Master Majoring in Biochemistry and Molecular Biology
2001-2005, Shandong University, Bachelor Majoring in Biology Science
2016-Present, School of Life Science and Technology / Frontier Institute of Science and Technology,
Xi'an Jiaotong University. Professor.
2012-2016, Frontier Institute of Science and Technology,
Xi'an Jiaotong University. Associate Professor.
2015-2018, UT Southwestern Medical Center, US. Posdoctoral Fellow.
Publications as Corresponding / First Author
(# indicates corresponding authors / * indicates first authors)
2010-2023 in reverse chronological order
Zeng, M.; Xu, J.; Zhang, Z.; Zou, X.; Wang, X.; Cao, K.; Lv, W.; Cui, Y.; Long, J.; Feng, Z.#; Liu, J.# Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes. Redox Biology. 2021 May; 41: 101948. (IF: 10.787, #Corresponding Authors)
Ke Cao, Weiqiang Lv, Shaoqin Hu, Jing Gao, Jiankang Liu,# and Zhihui Feng#. Punicalagin Activates AMPK/PGC-1α/Nrf2 Cascade in Mice: The Potential Protective Effect against Prenatal Stress. Mol Nutr Food Res. 2020 Jul; 64(14): e2000312. (IF: 6.575, #Corresponding Authors)
Yuting Cui, Yuan Li, Na Huang, Yue Xiong, Ruijun Cao, Lingjie Meng, Jiankang Liu#, Zhihui Feng#. Structure based modification of chalcone analogue activates Nrf2 in the T human retinal pigment epithelial cell line ARPE-19. Free Radic Biol Med. 2020 Feb 20; 148: 52-59. (IF: 8.101, #Corresponding Authors)
Feng, Z.*; Zou, X.*; Chen, Y.; Wang, H.; Duan, Y.; Bruick, R. Modulation of HIF-2α PAS-B domain contributes to physiological responses. PNAS. 2018 Dec; 115(52): 13240-13245. (IF: 12.779, *First Authors)
Li, Y.; Zou, X.; Gao, J.; Cao, K,; Feng, Z.#; Liu, J.# APR3 modulates oxidative stress and mitochondrial function in ARPE-19 cells. FASEB J. 2018 Nov; 32: 5851-5861. (IF: 5.834, #Corresponding Authors)
Jie Xu, Ke Cao, Zhihui Feng#, Jiankang Liu#. Benefits of the soluble and insoluble fractions of bitter gourd in mice fed a high-fat diet. Journal of Functional Foods. 42 (2018) 216–223. (IF: 5.223, #Corresponding Authors)
Hai‐Tao Yu, Xiao‐Yi Fu, Bing Liang, Shuang Wang, Jian‐Kang Liu, Shu‐Ran Wang#, Zhi‐Hui Feng#. Oxidative damage of mitochondrial respiratory chain in different organs of a rat model of diet‐induced obesity. Eur J Nutr. 2018 Aug; 57(5): 1957-1967. (IF: 4.865, #Corresponding Authors)
Jing Gao*, Zhihui Feng*, Xueqiang Wang, Mengqi Zeng, Jing Liu, Shujun Han, Jie Xu, Lei Chen, Ke Cao, Jiangang Long, Zongfang Li, Weili Shen and Jiankang Liu. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death Differ. 2018 Feb; 25(2): 229-240. (IF: 12.067, *First Authors)
Jie Xu, Xiaojie Wang, Ke Cao, Zhizhong Dong, Zhihui Feng# and Jiankang Liu#. Combination of β-glucan and Morus alba L. Leaf Extract Promotes Metabolic Benefits in Mice Fed a High-Fat Diet. Nutrients. 2017 Oct 12; 9(10): 1110. (IF: 6.706, #Corresponding Authors)
Wang X, Pang W, Wang X, Zhang Y, Feng Z#, Liu J#. Exercise promotes the beneficial effects of pomegranate peel extract on liver dysfunction in rats fed a high-fat diet. Current Topics in Nutraceutical Research. 2016 Oct; 14 (4): 241-250. (IF: 0.5, #Corresponding Authors)
Xun Wang*, Zhihui Feng*, Xueqiang Wang, Liang Yang, Shujun Han, Ke Cao, Jie Xu, Lin Zhao, Yong Zhang, Jiankang Liu. O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis. Diabetologia. 2016 Jun; 59(6): 1287-96. (IF: 10.460, *First Authors)
Chunhong Yan, Wenyan Sun, Xun Wang, Jiangang Long, Xuebo Liu, Zhihui Feng# and Jiankang Liu#. Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res. 2016 May; 60(5): 1139-49. (IF: 6.575, #Corresponding Authors)
Gao, J.; Zou, X.; Yang, L.; Feng, Z.#; Liu, J.# Hydroxytyrosol protects against acrolein induced preosteoblast cell toxicity: Involvement of Nrf2/Keap1 pathway. J Funct Foods. 2015 Dec; 19: 28-38. (IF: 5.223, #Corresponding Authors)
Ke Cao, Jie Xu, Wenjun Pu, Zhizhong Dong, Lei Sun, Weijin Zang, Feng Gao, Yong Zhang, Zhihui Feng# & Jiankang Liu#. Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation. Sci Rep. 2015 Sep 15; 5: 14014. (IF: 4.996, #Corresponding Authors)
Adi Zheng, Hao Li, Jie Xu, Ke Cao, Hua Li, Wenjun Pu, Ziqi Yang, Yunhua Peng, Jiangang Long, Jiankang Liu# and Zhihui Feng#. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr. 2015 Jun 14; 113(11): 1667-76. (IF: 4.125, #Corresponding Authors)
Zheng, A.; Li, H.; Cao, K.; Xu, J.; Zou, X.; Li, Y.; Chen, C.; Liu, J.; Feng, Z.# Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring. J Nutr Biochem. 2015 Feb; 26(2): 190-9. (IF: 6.117, #Corresponding Authors)
Wang, X.; Li, H.; Zheng, A.; Yang, L.; Liu, J.; Chen, C.; Tang, Y.; Zou, X.; Li, Y.; Long, J.; Liu, J.; Zhang, Y.#; Feng, Z.# Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate. Cell Death Dis. 2014 Nov 13; 5: e1521. (IF: 9.685, #Corresponding Authors)
Zou, X.; Yan, C.; Shi, Y.; Cao, K.; Xu, J.; Wang, X.; Chen, C.; Luo, C.; Li, Y.; Gao, J.; Pang, W.; Zhao, J.; Zhao, F.; Li, H.; Zheng, A.; Sun, W.; Long, J.; Szeto, IM.; Zhao, Y.; Dong, Z.; Zhang, P.; Wang, J.; Lu, W.; Zhang, Y.; Liu, J.#; Feng, Z.# Mitochondrial dysfunction in obesity associated non-alcoholic fatty liver disease: The protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 2014 Oct 10; 21(11): 1557-70. (IF: 7.468, #Corresponding Authors)
Cao, K.; Zhang, A.; Xu, J.; Li, H.; Liu, J.; Peng, Y.; Long, J.; Zou, X.; Li, Y.; Chen, C.; Liu, J.; Feng, Z.# AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med. 2014 Oct; 75: 156-66. (IF: 8.101, #Corresponding Authors)
Zhao L, Zou X, Feng Z#, Luo C, Liu J, Li H, Chang L, Wang H, Li Y, Long J, Gao F#, Liu J. Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol. 2014 Aug; 56: 3-12. (IF: 4.253, #Corresponding Authors)
Chen, C.; Han, X.; Zou, X.; Li, Y.; Yang, L.; Cao, K.; Xu, J.; Long, J.; Liu, J.; Feng, Z.# 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem. 2014 Jun 13; 289(24): 17184-94. (IF: 5.486, #Corresponding Authors)
Zou, X.; Gao, J.; Zheng, Y.; Wang, X.; Chen, C.; Cao, K.; Xu, J.; Li, Y.; Lu, W.; Liu, J.; Feng, Z.# Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death. Cell Death Dis. 2014 May 8; 5: e1218. (IF: 9.685, #Corresponding Authors)
Xu, J.; Cao, K.; Li, Y.; Zou, X.; Chen, C.; Szeto IM.; Dong, Z.; Zhao, Y.; Shi, Y.; Wang, J.; Liu, J.#; Feng, Z.# Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6mice fed a high-fat diet. Journal of Nutrition. 2014 Apr; 144(4): 475-83. (IF: 4.687, #Corresponding Authors)
Cao, K.; Xu, J.; Zou, X.; Li, Y.; Chen, C.; Zheng, A.; Li, H.; Li, H.; Man-Yau Szeto I.; Shi, Y.; Long, J.; Liu, J.#; Feng, Z.# Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2014 Feb; 67: 396-407. (IF: 8.101, #Corresponding Authors)
Zhao, L.; Feng, Z.#; Zou, X.; Cao, K.; Xu, J.; Liu, J.# Aging leads to elevation of O-GlcNAcylation and disruption of mitochondrial homeostasis in retina. Oxid Med Cell Longev. 2014; 2014: 425705. (IF: 7.310, #Corresponding Authors)
Li, Y.; Zou, X.; Cao, K.; Xu, J.; Yue, T.; Dai, F.; Zhou, B.; Lu, W.; Feng, Z.#; Liu, J.# Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity. Toxicol Appl Pharmacol. 2013 Nov 1; 272(3): 726-35. (IF: 4.460, #Corresponding Authors)
Jiong Yan*, Zhihui Feng*, Jia Liua, Weili Shenc, Ying Wangd, Karin Wertzd, Peter Weberd, Jiangang Longa, Jiankang Liu. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto–Kakizaki (GK) rats: ameliorating effects of (−)-epigallocatechin-3-gallate. J Nutr Biochem. 2012 Jul; 23(7): 716-24. (IF: 6.117, *First Authors)
Feng, Z.*; Zou, X.*; Jia, H.; Li, X.; Zhu, Z.; Liu, X.; Bucheli, P.; Ballevre, O.; Hou, Y.; Zhang, W.; Wang, J.; Chen, Y.; Liu, J. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. Antioxid Redox Signal. 2012 Feb 1; 16(3): 275-89. (IF: 7.468, *First Authors)
Zhihui Feng*, Liyuan Bai*, Jiong Yan, Yuan Li, Weili Shen, Ying Wang, Karin Wertz, Peter Weber, Yong Zhang, Yan Chen, Jiankang Liu. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol. Free Radic Biol Med. 2011 May 15; 50(10): 1437-46. (IF: 8.101, *First Authors)
Zhihui Feng*, Zhongbo Liu, Xuesen Li, Haiqun Jia, Lijuan Sun, Chuan Tian, Lihong Jia, Jiankang Liu. α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec; 21(12): 1222-31. (IF: 6.117, *First Authors)
Zhihui Feng*, Haiqun Jia, Xuesen Li, Zhuanli Bai, Zhongbo Liu, Lijuan Sun, Zhongliang Zhu, Peter Bucheli, Olivier Ballèvre, Junkuan Wang, Jiankang Liu. A milk-based wolfberry preparation prevents prenatal stress-induced cognitive impairment of offspring rats, and inhibits oxidative damage and mitochondrial dysfunction in vitro. Neurochem Res. 2010 May; 35(5): 702-11. (IF: 4.414, *First Authors)
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Other Publications as Co-Author
2008-2023 in reverse chronological order