Basic Information

 

张琰,助理教授

 生命学院

生物医学信息与基因组学中心

Contact Information

Email:zhangyan11@xjtu.edu.cn

地址:陕西省西安市秦都区中国西部科技创新港18号楼5082室

Research Fields

骨相关疾病发病机制的解析、复杂疾病非编码区易感变异位点/基因的鉴定及其致病机理的研究、转录因子相分离机制研究等。

Work Experience

1. Yan Zhang#, Tao Zuo#, Abigail McVicar, Huilin Yang, Yi-Ping Li*, Wei Chen*. Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis. Bone Research. 2022, 10(1):63. (1Top, IF=12.7)

2. Yan Zhang, Huiwen Chen, Jinjin Wu, Abigail McVicar, Yilin Chen, Jiacan Su, Yi-Ping Li*, Wei Chen*. Deficiency of Cbfβ in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFβ, and Wnt-catenin signaling pathways. International Journal of Biological Sciences. 2024, 20(6): 1965-1977. (2Top, IF=9.2)

3. Yan Zhang, He Wang, Guochun Zhu, Airong Qian*, Wei Chen*. F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NF-κB signaling pathways. International Journal of Biological Sciences. 2020, 16(9): 1629-1639. (2, IF=9.2)

4. Yan Zhang#, Chong Yin#, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang*, Airong Qian*, Cory J. Xian. MACF1 Overexpression by Transfecting the 21-kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation. Human Gene Therapy. 2018, 29(2): 259-270. (2, IF=4.2)

5. Nai-Ning Wang#, Yan Zhang#, Feng Jiang#, Dong-Li Zhu, Chen-Xi Di, Shou-Ye Hu, Xiao-Feng Chen, Li-qiang Zhi, Yu Rong, Xin Ke, Yuan-Yuan Duan, Shan-Shan Don, Tie-Lin Yang, Zhi Yang*, Yan Guo*. Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis. American Journal of Human Genetics. 2023, 110 (4), 625-637.  (1Top, IF=9.8)

6. Fei Chen#, Yan Zhang#, Pei Peng, Xiao-Ting Huang, Zi-Han Qiu, Bao-Cheng Liu, Tie-Lin Yang, Bo Yang*, Yan Guo*. Isolation and culture of human primary osteoblasts: Comparing the effects of differences in method details on osteoblast characteristics. Genes & Diseases. 2023, 11(2):546-549. (2, IF=6.8)

7. Zhihao Chen#, Yan Zhang#, Fan Zhao, Chong Yin, Chaofei Yang, Xue Wang, Zixiang Wu, Shujing Liang, Dijie Li, Xiao Lin, Ye Tian, Lifang Hu*, Yu Li, Airong Qian*. Recombinant irisin prevents the reduction of osteoblast differentiation induced by stimulated microgravity through increasing β-catenin expression. International Journal of Molecular Sciences. 2020, 21(4): 1259. (2, IF=5.6)

8. Chong Yin#, Yan Zhang#, Lifang Hu, Ye Tian, Zhihao Chen, Dijie Li, Fan Zhao, Peihong Su, Xiaoli Ma, Ge Zhang, Zhiping Miao, Liping Wang*, Airong Qian*, Cory J. Xian. Mechanical unloading reducesmicrotubule actin crosslinking factor 1 expression to inhibit beta-catenin signaling and osteoblast proliferation, Journal of Cellular Physiology. 2018, 233(7): 5405-5419. (2, IF=5.6)

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