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王维蓉 教授

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  • 发布时间:2021-09-28
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王维蓉,医学博士,教授,病理学与病理生理学 博士生导师。 1F5F7

新乡医学院临床医学专业学士、药理学专业硕士和博士,病理学与病理生理学博士后,美国华盛顿大学(西雅图)访问学者。现为转化医学研究院心血管研究所Co-PI。

科研:研究方向为心血管疾病的发生发展机制及药物防治主持国家及省部级基金项目8项,其中主持国家自然科学基金2项、中国博士后基金2项、省部校级基金4项。发表SCI收录论文50余篇,以第一/通讯作者发表SCI收录论文15篇,参与授权专利5项。

教学:为本科生、研究生、留学生主讲《医学实验动物学》、《动物实验和实验动物学》、《Animal Experiment and Laboratory Animal Science》课程。参编研究生教材《人类疾病动物模型》、《高等药理学》等专著5部。担任侯宗濂医学实验班和基础医学专业学生学业导师和学术导师,指导大学生创新训练项目5项。

社会兼职:中国药理学会生化与分子药理学专业委员会委员、中国药理学会抗炎免疫药理学专业委员会青年委员、陕西省药理学会生化与分子药理学专业委员会常务委员等。《中国临床药理学与治疗学》和《中国动脉硬化杂志》青年编委。 

代表性论文

1. Chen L, Wang G, He J, Yang X, Zheng Z, Deng Y, Liu Y, Chen D, Lin R, Wang W*. SIRT6 inhibits endothelial-to-mesenchymal transition through attenuating the vascular endothelial inflammatory response. International Immunopharmacology. 2021,101:108240.(通讯作者)

2. Chen L, Shang X, Wang B, Wang G, Jin Z, Yao F, Yue Z, Bai L, Wang R, Zhao S, Liu E, Wang W*. HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis. Biochemical Pharmacology. 2021,192:114716.(通讯作者)

3. Wang W, Chen L, Shang C, Jin Z, Yao F, Bai L, Wang R, Zhao S, Liu E. miR-145 inhibits the proliferation and migration of vascular smooth muscle cells by regulating autophagy. Journal of Cellular and Molecular Medicine, 2020,12:6658-6669.

4. Wang W, Shang C, Zhang W, Jin Z, Yao F, He Y, Wang B, Li Y, Zhang J, Lin R. Hydroxytyrosol NO regulates oxidative stress and NO production through SIRT1 in diabetic mice and vascular endothelial cells. Phytomedicine, 2019,52:206-215.

5. Li Y, Yao F, Shang C, Ren F, Zhang J, Li Y, Yang G, Lin R*Wang W*. Preparation, characterization and in vivo evaluation of pharmacological activity of different crystal forms of ibuprofen. Pakistan Journal of Pharmaceutical Sciences, 2019,32:2139-2147.(通讯作者)

6. Wang W, Chen Y, Bai L, Zhao S, Wang R, Liu B, Zhang Y, Fan L, Liu E. Transcriptomic analysis of the liver of cholesterol-fed rabbits reveals altered hepatic lipid metabolism and inflammatory response. Scientific Reports, 2018,8:6437. 

7. Wang W, Jing T, Yang X, He Y, Wang B, Xiao Y, Shang C, Zhang J, Lin R.  Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through SIRT1-mediated signaling pathway. Canadian Journal of Physiology and Pharmacology, 2018,96:88-96.

8. Wang W, Li T, Jing T, Li Y, Yang X, He Y, Zhang W, Zhang J, Lin R. SIRT1 regulates the inflammatory response of vascular adventitial fibroblasts through autophagy and related signaling pathway. Cellular Physiology and Biochemistry, 2017,41:569-582.

9. Wang W, Liu E, Zhang J, Li Y, Yang X, He Y, Zhang W, Jing T, Lin R. Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1. Experimental Cell Research, 2015,338:54-63.

10. Wang W, Zhang J, Li Y, Yang X, He Y, Li T, Ren F, Zhang J, Lin R. Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1. Cancer Letters, 2015,356:791-799.

邮箱:szb2013072@xjtu.edu.cn

 

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