研究领域（方向）：

• 基于微生物间相互作用特性的靶向递送系统的设计与开发；

• 基于不同病原微生物感染特征的药物作用靶点筛选及干预策略研究。

教育经历：

• 2013-09至 2017-09, , 药理学, 博士

• 2007-02至 2011-06, 天津理工大学, 制药工程, 学士

工作经历：

• 2022-05至 今, , 药学院, 副教授

• 2018-05至 2022-05, , 第一附属医院, 助理研究员

主要科研项目

• 2020-2022 Cas5关键磷酸化位点对白色念珠菌细胞壁压力应激通路的调控作用及机制研究(国家自然科学基金)

• 2019-2020 Cas5介导的白色念珠菌细胞壁应激关键蛋白结构作用研究（中国博士后科学基金）

• 2019-2020白色念珠菌细胞壁完整性调控因子Cas5蛋白的结构解析（陕西省自然科学基金）

• 2023-2025 组蛋白去乙酰化酶Sir2介导白色念珠菌细胞壁重塑调控其与宿主之间相互作用及机制研究（基本科研业务费）

学术及科研成果、专利、论文

• Peipei Zhang; Xiaohui Zhao; Yawen Wang; Ke Du; Zhihao Wang; Jianfeng Yu; Gang Chang;Steve Matthews; Hongliang Wang; Bing Liu ; Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins, PNAS, 2022, 119(9): e2116278119

• Chen Yang; Guanglin Li; Qiyue Zhang; Wenhui Bai; Qingqing Li;Peipei Zhang*; Jiye Zhang*;Histone deacetylase Sir2 promotes the systemic Candida albicans infection by facilitating its immune escape via remodeling the cell wall and maintaining the metabolic activity, Mbio. 2024 (accepted).

• Peipei Zhang; Zhihao Wang; Yawen Wang; Steve Matthews; Ling Lan; Bing Liu; 1H, 13C and 15N NMR assignments of Bacillus subtilis bacteriophage SPO1 protein Gp46, Biomolecular NMR Assignments, 2019, 13(1): 245-274

• Peipei Zhang;Xiaofeng Yang; Yanhao He; Zhuo Chen; Bing Liu; Emesto Contta; Guangde Yang; Weirong Wang; Jiye Zhang; Rong Lin; Preparation, characterization and toxicity evaluation of amphotericin B loaded MPEG-PCL micelles and its application for buccal tablets, Applied Microbiology and Biotechnology, 2017, 19(101): 7357-7370

• Li Zhou^#;Peipei Zhang^#; Zhuo Chen; Shaona Cai; Ting Jing; Huihui Fan; Fei Mo; Jiye Zhang; Preparation, characterization and toxicity evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral candida albicans, International Journal of Nanomedicine, 2017, 211(12): 4269-4283

• Fei Mo;Peipei Zhang; Qingqing Li; Xianwei Yang; Jia Ma; Jiye Zhang; Development andEvaluation of a Film Forming System Containing Myricetin and Miconazole Nitrate for Preventing Candida albicans Catheter-Related Infection, Microbial Drug Resistance, 2022, 28(4): 468-483

• Ximeng Kang; Jiaxing Lei; Chen Yang;Peipei Zhang; Xiaojiao Li; Shaohua Zheng; Qingqing Li *; Jiye Zhang*；A hybrid hydrogel composed of chitin and β-glucan for effectively management of wound healing and scarring，Biomaterials Science, 2022，doi: 10.1039/d2bm00935h.

• Qingqing Li; Xianwei Yang;Peipei Zhang; Fei Mo; Peiru Si; Ximeng Kang; Menghan Wang; Jiye Zhang*; Dasatinib loaded nanostructured lipid carriers for effective treatment of corneal neovascularization, Biomaterials Science, 2021, 9: 2571-2583.

• Fei Mo; Jia Ma; Xianwei Yang;Peipei Zhang; Qingqing Li; Jiye Zhang*; In vitro and in vivo effects of the combination of myricetin and miconazole nitrate incorporated to thermosensitive hydrogels on C. albicans biofilms, Phytomedicine, 2020, 71(6): 153223.

• Xianwei Yang; Menghan Wang; Ximeng Kang; Fei Mo; Peiru Si; Jia Ma;Peipei Zhang; Shaohua Zheng; Jiyu Li; Yang Wang; Qingqing Li*; Jiye Zhang*; L-Se-methylselenocysteine loaded mucoadhesive thermogel for effective treatment of Vulvar candidiasis, International Journal of Pharmaceutics, 2022, 622: 121851.

• Bing Liu; Denghui Liu; Xin Wang;Peipei Zhang; Yawen Wang; Chi Xu; Nan Qiao; Use ofbelinostat or pharmaceutically acceptable salt thereof in preparation of drug for treating infection, 2023-11-28,美国, 17/860,889 (专利)

• 李清清;张继业;马骁;康曦萌;雷佳星;杨晨;张沛沛; 王飞飞;一种抑制瘢痕形成的水凝胶组合物及其制备方法与应用, 2023-11-28,中国, CN202210314579.3 (专利)

• 张继业;莫菲;张沛沛;李清清;杨显伟;马佳;苏进;一种预防经皮置管导管外表面感染的联合杨梅素/唑类药物的涂膜剂及其应用, 2022-8-16,中国, ZL202110114115.3 (专利)

联系方式

电子邮箱：peipei2018@xjtu.edu.cn.

联系地址：陕西省西安市西咸新区创新港校区泓仁楼21-1042室