研究领域（方向）

复杂体系中抗过敏活性成分筛选发现

抗过敏性药物发现与机制研究

过敏性疾病的发生机制

个人及工作简历

个人受教育及工作经历

2004.9-2008.7陕西师范大学本科

2009.9-2014.12博士

2014.12-2018.6讲师

2016.12-2017.12约翰∙霍普金斯大学访问学者

2018.6至今副教授

科研项目

1.国家自然科学基金青年项目1项（2015-2017）

2.国家博士后基金面上项目2项（2016-2018，2019-2021）

3.陕西省自然科学基金青年项目1项（2015-2016）

4.中央高校基本科研业务费1项（2018-2020）

学术及科研成果、专利、论文

以第一及通讯作者发表SCI论文18篇，申请专利6项，授权2项。

近年发表部分SCI论文如下：

1.Nan Wang, Langchong He*, et al. Imperatorin ameliorates mast cell-mediated allergic airway inflammation by inhibiting MRGPRX2 and CamKII/ERK signaling pathway. Biochemical Pharmacology. 2021, 184: 114401.

2.Nan Wang, Shengli Han, Rui Liu, Liesu Meng, Huaizhen He, Shemin Lu*, Langchong He* et al. Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus. Phytomedicine. 2020, 79: 153333.

3.Jue Wang, Nan Wang*, et al. Isoimperatorin reduces the effective dose of dexamethasone in a murine model of asthma by inhibiting mast cell activation. Phytotherapy Research. 2020, 34: 2985-2997.

4.Yingnan Zeng, Nan Wang*, et al. Gold induces a pseudo-allergic reaction via MRGPRX2 bothin vitroandin vivo. Cellular Immunology 2019, 341: 103923.

5.Jue Wang, Nan Wang*, et al. Baicalin induces Mrgprb2-dependent pseudo-allergy in mice. 2020. Immunology Letters. 2020, 226: 55-61.

6.Yongjing Zhang, Nan Wang*, et al. Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2. Virology. 2020, 16: 83-88.

7.Rui Liu, Nan Wang*, et al. Relationship between MRGPRX2 and pethidine hydrochloride- or fentanyl citrate-induced LAD2 cell degranulation. Journal of pharmacy and pharmacology.

8.Yongjing Zhang, Nan Wang*, et al. Roxithromycin inhibits compound 48/80-induced pseudo-allergy via the MrgprX2 pathway both in vitro and in vivo. Cellular Immunology.

9.Yongjing Zhang, Nan Wang*, et al. Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2.Virology. 2020, 554: 83–88.

10.Shiling Hu, Nan Wang*, Langchong He*, et al. Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2. Journal of Medical Virology. 2021:1–9.

11.Wang Jue;Zhang Yongjing;Hu Shiling;Ge Shuai;Jia Min;Wang Nan.Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway. International immunopharmacology. 2021, 93:107426.

联系方式

电子邮箱：wangnan2014@xjtu.edu.cn

联系电话：

个人主页：http://gr.xjtu.edu.cn/web/wangnan2014

联系地址：西安市长安区钓台街道中国西部创新港21号楼5103