研究领域（方向）

研究方向为化学/生物药物递送系统设计评价、抗菌药物作用靶点筛选、创新生物材料、创新医疗器械研发设计及评价等

个人及工作简历

2020.1-今 医学部药学院 药剂学专业教授

2014.12-2019.12 医学部药学院 药剂学专业副教授

2011.2-2014.12医学部药学院药剂学专业 讲师

2000.9-2004.7药学院药学专业 获理学学士学位

2004.9-2007.5医学院药物分析专业 获医学硕士学位

2007.9-2010.12医学院药理专业 获医学博士学位

科研项目

学术及科研成果、专利、论文

近5年论文：

[1] Chen Yang, Guanglin Li, Qiyue Zhang, Wenhui Bai, Qingiqng Li, Peipei Zhang*,Jiye Zhang*; Histone deacetylase Sir2 promotes the systemic Candida albicans infection by facilitating its immune escape via remodeling the cell wall and maintaining the metabolic activity, mBio, 2024 10.1128/mbio.00445-24

[2]Chen Yang, Jiaxing Lei, Ximeng Kang, Peipei Zhang, Shaohua Zheng, Qingqing Li*,Jiye Zhang*; A Yeast Cell Wall Derived Hybrid Hydrogel with Photothermal and Immune Combined Modality Therapy for Enhanced Anti-Melanoma Efficacy, International Journal of Nanomedicine 2023:18 5423–5440

[3] Peiru Si, Jiaxing Lei, Chen Yang, Peipei Zhang, Xiaojiao Li, Shaohua Zheng, Qingqing Li*,Jiye Zhang*; Mesoporous Hollow Manganese Doped Ceria Nanoparticle for Effectively Prevention of Hepatic Ischemia Reperfusion Injury, International Journal of Nanomedicine,2023:18 2225–2238

[4] Jia Ma; Daoxia Guo; Xiaoyuan Ji; Yanfeng Zhou; Chang Liu; Qian Li;Jiye Zhang*; Chunhai Fan*; Haiyun Song*; Composite Hydrogel for Spatiotemporal Lipid Intervention of Tumor Milieu, Advanced Materials, 2023, 2211579

[5] Fei Mo; Peipei Zhang; Qingqing Li; Xianwei Yang; Jia Ma;Jiye Zhang*; Development and evaluation of a film forming system containing myricetin and miconazole nitrate for preventing Candida albicans catheter-related infection, Microb Drug Resist, 2022, 28(4):468-483.

[6]Ximeng Kang; Jiaxing Lei; Chen Yang; Peipei Zhang; Xiaojiao Li; Shaohua Zheng;Qingqing Li*;Jiye Zhang*；A hybrid hydrogel composed of chitin and β-glucan for effectively management of wound healing and scarring, Biomaterials Science, 2022, 10: 6024-6036

[7] Xianwei Yang, Menghan Wang, Ximeng Kang, Fei Mo, Peiru Si, Jia Ma, Peipei Zhang, Shaohua Zheng, Jiyu Li, Yang Wang, Qingqing Li*,Jiye Zhang*L-Se-methylselenocysteine loaded mucoadhesive thermogel for effective treatment of Vulvar candidiasis. International Journal of Pharmaceutics. 2022 622: 121851

[8] Jia Ma, Jing Huang, Jinli Sun, Yanfeng Zhou, Xiaoyuan Ji, Daoxia Guo, Chang Liu, Jiyu Li,Jiye Zhang*, Haiyun Song*. L-Se-methylselenocysteine sensitizes lung carcinoma to chemotherapy. Cell Proliferation. 2021, 00:e13038

[9] Qingqing Li, Xianwei Yang, Peipei Zhang, Fei Mo, Peiru Si, Ximeng Kang, Menghan Wang andJiye Zhang*. Dasatinib loaded nanostructured lipid carriers foreffective treatment of corneal neovascularization. Biomaterials Science. 2021, 7:2571-2583

[10] Fei Mo, Jia Ma, Xianwei Yang , Peipei Zhang, Qingqing Li,Jiye Zhang*. In vitro and in vivo effects of the combination of myricetin and miconazole nitrate incorporated to thermosensitive hydrogels, on C. albicans biofifilms. Phytomedicine 2020, 71: 153223

[11] Huihui Fan,, Peipei Zhang, Li Zhou, Fei Mo, Zhen Jin, Jia Ma, Rong Lin, Ying Liu,Jiye Zhang*. Naringin-loaded polymeric micelles as buccal tablets: formulation, characterization, in vitro release, cytotoxicity and histopathology studies. Pharmaceutical development and technology 2020, 25(1):1-31

专利 ：

[1] 张继业，莫菲，张沛沛，李清清，杨显伟，马佳，苏进 一种预防经皮置管导管外表面感染的联合杨梅素/唑类药物的涂膜剂及其应用。发明专利 专利号：ZL201110114115.3

[2] 张继业，林蓉，刘婷婷. 一种测量生物黏附制剂体外释放度及黏附时间/溶蚀时间的的装置. 实用新型专利 专利号：ZL 201320445613.7

[3] 张继业，林蓉，刘婷婷. 一种测量生物黏附制剂体外释放度及黏附时间/溶蚀时间的的方法. 发明专利 专利号：ZL201310314847.2

[4] 张继业，林蓉，许加成. 一种测量生物粘附制剂体外粘附力的装置 实用新型专利 专利号：ZL201320673633.X

[5]李清清，张继业，马骁，康曦萌，雷佳星，杨晨，张沛沛，王飞飞. 一种抑制瘢痕形成的水凝胶组合物及其制备方法与应用 发明专利 专利号：CN114748413B

联系方式

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