武一，博士，教授，免疫学、生化与分子生物学博士生导师。
清华大学材料科学学士、生物物理学博士。曾任兰州大学生命科学学院教授（2003-2015）；现任转化医学研究院PI（2015至今）。
科研：研究方向为重要急性期蛋白的基础生物学及诊疗应用研究。主持国家自然科学基金重点、优青、国合、面上等项目及省部级各类项目30余项。已在Cell Res、JASN、Cardiovasc Res、PNAS、ATVB、CMGH、eLife等学术期刊发表研究论文40余篇，获引用3000余次。曾获国家自然科学奖二等奖（3/5）、陕西省自然科学奖二等奖（1/5）、陕西高等学校科学技术研究优秀成果奖一等奖（1/5）、贝时璋青年生物物理学家奖等。曾入选国家优青、教育部新世纪优秀人才、陕西省百人计划等。
教学：为本科生、研究生讲授《生物化学》、《人体分子与细胞》等课程。培养硕士、博士研究生20余名。
社会兼职：现任Frontiers in Immunology (2022至今)、Biophysics Reports（2017至今）、生物物理学报等副主编；任国际动脉粥样硬化学会中国分会理事、中国生物物理学会膜生物学、冷冻电子显微学、分子生物物理学等分会理事、中国生物化学与分子生物学会蛋白质专业分会理事、陕西省实验动物学会常务理事等。
代表性论文
1. Zhou L, Chen S.-J., Chang Y., Liu S.-H., Zhou Y.-F., Huang X.-P., Hua Y.-X., An H., Zhang S.-H., Melnikov I., Gabbasov Z. A., Wu Y.*, Ji S.-R.* (2023) Monomeric C-reactive protein evokes TCR signaling-dependent bystander activation of CD4+ T cells. Molecular Immunology, 157(5): 158-166.
2. Ji S.-R.*, Zhang S.-H., Chang Y., Li H.-Y., Wang M.-Y., Lv J.-M., Zhu L., Tang P.M.K., Wu Y.* (2023) C-reactive protein: the most familiar stranger. Journal of Immunology, 210(6): 699-707.
3. Wang M.-Y., Zhang C.-M., Zhou H.-H., Ge Z.-B., Su C.-C., Lou Z.-H., Zhang X.-Y., Xu T.-T., Li S.-Y., Zhu L., Zhou Y.-L., Wu Y.*, Ji S.-R.* (2022) Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein. Journal of Biological Chemistry, 298(8): 102160.
4. Cheng B., Lv J.-M., Liang Y.-L., Zhu L., Huang X.-P., Li H.-Y., Potempa L.A., Ji S.-R.*, Wu Y.* (2022) Secretory quality control constrains functional selection-associated protein structure innovation. Communications Biology, 5: 268.
5. Li H.-Y., Tang Z.-M., Wang Z., Lv J.-M., Liu X.-L., Liang Y.-L., Cheng B., Gao N., Ji S.-R.*, Wu Y.* (2022) C-reactive protein protects against acetaminophen-induced liver injury by preventing complement overactivation. Cellular and Molecular Gastroenterology and Hepatology, 13(1): 289-307.
6. Wang M.-Y., Zhou H.-H., Zhang C.-M., Su H.-X., Li S.-L., Ji S.-R., Liu E.-Q.*, Wu Y.* (2020) A functional genetic variant at C-reactive protein promoter (rs3091244) is not associated with cancer risk in a Chinese population. Frontiers in Immunology, 11: 926.
7. Liu Y., Yuan B., Peng L., Zhao J., Zhou Y., Xiang S., Zhu L.*, Wu Y.* (2020) Single-particle analysis of urea amidolyase reveals its molecular mechanism. Protein Science, 29(5): 1242-1249.
8. Zhang S.-C., Wang M.-Y., Feng J.-R., Chang Y., Ji S.-R.*, Wu Y.* (2020) Reversible promoter methylation determines fluctuating expression of acute phase proteins. eLife, 9: e51317.
9. Li H.-Y., Liu X.-L., Liu Y.-T., Jia Z.-K., Filep J.G., Potempa L.A., Ji S.-R.*, Wu Y.* (2019) Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein. Cardiovascular Research, 115(2): 440-452.
10. Zhang L., Li H.-Y., Li W., Shen Z.-Y., Wang Y.-D., Ji S.-R.*, Wu Y.* (2018) An ELISA assay for quantifying monomeric C-reactive protein in plasma. Frontiers in Immunology, 9: 511.
11. Jia Z.-K., Li H.-Y., Liang Y.-L., Potempa L.A., Ji S.-R.*, Wu Y.* (2018) Monomeric C-reactive protein binds and neutralizes receptor activator of NF-κB ligand-induced osteoclast differentiation. Frontiers in Immunology, 9: 234.
12. Lv J.-M., Lv S.-Q., Liu Z.-P., Zhang J., Gao B.-X., Yao Z.-Y., Wu Y.-X., Potempa L.A., Ji S.-R.*, Long M.*, Wu Y.* (2018) Conformational folding and disulfide bonding drive distinct stages of protein structure formation. Scientific Reports, 8: 1494.
13. Li Q.-Y., Li H.-Y., Fu G., Yu F.*, Wu Y.*, Zhao M.-H. (2017) Autoantibodies against C-reactive protein influence complement activation and clinical course in lupus nephritis. Journal of the American Society of Nephrology, 28(10): 3044-3054.
14. Li H.-Y., Wang J., Meng F., Jia Z.-K., Su Y., Bai Q.-F., Lv L.-L., Ma F.-R., Potempa L.A., Ji S.-R.*, Wu Y.* (2016) An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein. Journal of Biological Chemistry, 291(16): 8795-8804.
15. Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*, Wu Y.* (2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. Journal of Immunology, 194(11): 5243-5252.
16. Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A., Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses. Journal of Biological Chemistry, 289(20): 14283-14290.
17. Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*, Wu Y.* (2014) Recurrent mutations at C-reactive protein gene promoter SNP position -286 in human cancers. Cell Research, 24(4): 505-508.
18. Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y., Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. Journal of Biological Chemistry, 287(1): 748-756.
19. Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*, Wu Y.* (2011) A redox switch in C-reactive protein modulates activation of endothelial cells. FASEB Journal, 25(9): 3186-3196.
20. Zhu L., Chen L., Zhou X.-M., Zhang Y.-Y., Zhang Y.-J., Zhao J., Ji S.-R., Wu J.-W.*, Wu Y.* (2011) Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure, 19(4): 515-522.
21. Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J., Wu Y.* (2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. FASEB Journal, 23(6): 1806-1816.
22. Ji S.-R., Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm. FASEB Journal, 21(1): 284-294.
23. Ji S.-R., Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions. Arteriosclerosis Thrombosis and Vascular Biology, 26(4): 935-941.
24. Ji S.-R., Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis. International Journal of Biochemistry & Cell Biology, 384(4): 648-661.
25. Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087.
26. Ji S.-R., Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation. Journal of Biological Chemistry, 277(8): 6273-6279.
27. Wu Y., Ji S.-R., Wang H.-W., Sui S.-F.* (2002) Study of the spontaneous dissociation of rabbit C-reactive protein. Biochemistry (Moscow), 67(12): 1377-1382.
邮箱：wuyi_med@xjtu.edu.cn
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