个人简介：

李宏宝，副教授，硕/博士生导师。

主要研究方向为：宿主肠道微生物与心血管疾病、慢性肾脏病。2017-2018年在美国佛罗里达大学Mohan K Raizada教授实验室公派访学。目前主持国家自然科学基金2项、中国博士后面上项目2项、陕西省重点研发项目1项、陕西省博士后基金1项、陕西省自然科学基金青年项目1项，教育部春晖计划项目1项，另参与国家自然科学基金重大研究计划项目、面上项目等多个科研项目。累计发表SCI论文45篇，其中以第一作者/通讯作者在Circulation Research, Hypertension, Gut Microbes等国际学术期刊上发表SCI收录论文16篇。其中影响因子大于10的高水平SCI论文3篇。目前任陕西省生理科学会理事。陕西省健康促进与教育协会血液净化专业委员会副主任委员。任SCI杂志Frontiers in Nutrition (IF=6.57；副主编)，Nutrients (IF=6.706；客座副主编)，Frontiers in Cellular and Infection Microbiology (IF=6.073；副主编)，Cardiovascular Toxicology(IF=3.23)编委，中华高血压杂志青年编委等。获陕西省高等学校科学技术二等奖1项。

 

研究领域（方向）：

1. 宿主肠道微生物与心血管疾病、慢性肾脏病；

2. 宿主肠道微生物与肺动脉高压。

教育与工作经历：

2012年获兰州大学生理学硕士学位。2015年毕业于医学院，获博士学位，并留校工作。2017-2018年在美国佛罗里达大学公派访学。2019/03-至今，，副教授/博导。

国际合作与交流情况：

目前主要与美国佛罗里达大学Mohan K Raizada教授，美国托莱多大学的Bina Joe教授和杨涛助理教授合作。

 

主持科研项目情况：

  1. 国家自然科学基金面上项目，2022-01至2025-12，在研，主持

  2. 国家自然科学基金青年项目，2018-01至2020-12, 已结题，主持

  3. 基本科研业务费，2020-01至2022年-12，在研，主持

  4. 陕西省重点研发一般项目，2021-01至2022-12，在研，主持

  5. 中国博士后面上项目一等资助，2020-01至2021-12, 在研，主持

    6. 教育部“春晖计划”合作科研项目，2020-01至2021-12, 在研，主持

    7. 陕西省自然科学基金青年项目，2017-01至2018-12，已结题，主持

8. 中国博士后面上项目二等资助，2017-01至2018-12，已结题，主持

9. 陕西省博士后基金项目，2016-01至2017-12月，已结题，主持

 

近五年发表部分论文情况：本人通讯作者以*标出

  1. Hong-Bao Li*(通讯作者), Meng-Lu Xu, Xu-Dong Xu, Yu-Yan Tang, Hong-Li Jiang, Lu Li, Wen-Jie Xia, Nan Cui, Juan Bai, Zhi-Ming Dai, Bei Han, Ying Li, Bo Peng, Yuan-Yuan Dong, Sachin Aryal, Ishan Manandhar, Mahmoud Ali Eladawi, Rammohan Shukla, Yu-Ming Kang*, Bina Joe*, Tao Yang*, Faecalibacterium prausnitzii attenuates CKD via butyrate-renal GPR43 axis，Circulation Research，2022,131(9):e120-e134. IF: 23.213 (封面论文).

  2. Meng-Lu Xu, Bo Peng, Juan Bai, Lu Li, Yan Du, Zhi-Qiang Wang, Sha-Sha Li, Xiao-Xi Liu, Yuan-Yuan Dong, Jun-Zhe Wu, Ling-Xiao Xiong, Lei Chen, Hong-Bao Li*(通讯作者), Hong-Li Jiang*, Diosgenin exerts an antihypertensive effect in spontaneously hypertensive rats via gut-brain communication, Food & Function, 2022, 13(18):9532-9543. IF: 6.317.

  3. Lin Song, Jiaqi Cui, Shuyuan Hu, Rui Wang, Hong-Bao Li*(通讯作者), Bo Sun*, Maternal treatment with metformin persistently ameliorates high-Fat diet-induced metabolic symptoms and modulates gut microbiota in rat offspring, Nutrients, 2022, 14(17):3612. IF: 6.706.

  4. Wen-Jie Xia, Meng-Lu Xu, Xiao-Jing Yu, Meng-Meng Du, Xu-Hui Li, Tao Yang, Lu Li, Qing Su, Jia-Xi Xu, Xiao-Lian Shi, Hong-Bao Li*(通讯作者), Yu-Ming Kang, Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat, Gut Microbes, 2021, 13(1):1-24. IF: 10.245.

  5. Hong-Bao Li, Meng-Lu Xu, Meng-Meng Du, Xiao-Jing Yu, Juan Bai, Wen-Jie Xia, Zhi-Ming Dai, Chang-Xing Li, Ying Li , Qing Su, Xiao-Min Wang, Yuan-Yuan Dong, Yu-Ming Kang，Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat, Toxicology and Applied Pharmacology, 2021, 429:115701.

  6. Ying Li, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia, Hong-Bao Li*(通讯作者), Yu-Ming Kang*, Altered gut microbiota is involved in the anti-hypertensive effects of Vitamin C in spontaneously hypertensive rat, Molecular Nutrition and Food Research, 2021, 65(7):e2000885. IF: 6.575 (封面论文)

  7. Ying Li*, Salman Zafar, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia, Hong-Bao Li*(通讯作者), Yu-Ming Kang*, Exercise and food supplement of vitamin C ameliorate hypertension through improvement of gut microflora in the spontaneously hypertensive rats, Life Sciences, 2021, 269:119097. IF: 6.780.

  8. Hong-Bao Li, Tao Yang，Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male Offspring，Hypertension, 2020, 75:1315-1324. IF: 10.19.

  9. Hong-Bao Li, Xiao-Jing Yu, Juan Bai, Qing Su, Mo-Lin Wang, Chan-Juan Huo, Wen-Jie Xia, Qiu-Yue Yi, Kai-Li Liu, Li-Yan Fu, Guo-Qing Zhu, Jie Qi, Yu-Ming Kang, Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus, International Journal of Cardiology, 2019, 280:142-151.

  10. Hui Zhang, Hong-Bao Li (共同一作), Jian-Rui Lyu, Xiao-Ming Lei, Wei Li, Gang Wu, Jun Lyu, Zhi-Ming Dai, Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection, International Journal of Infectious Diseases, 2020, 96:19-24.

  11. Meng-Lu Xu, Xiao-Jing Yu, Jian-Qiang Zhao, Yan Du, Wen-Jie Xia, Qing Su, Meng-Meng Du, Qing Yang, Jie Qi, Ying Li, Shao-Wen Zhou, Guo-Qing Zhu, Hong-Bao Li*(通讯作者), Yu-Ming Kang. Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR. Toxicology and Applied Pharmacology, 2020, 394:114950.

  12. Tao Yang, Hong-Bao Li, Aline C Oliveira, Ruby Goel，Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada,Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats，Physiological Genomics，2020, 2(3):121-132.

  13. Tao Yang, Victor Aquino, Gilberto O. Lobaton, Hong-Bao Li, Luis Colon-Perez, Ruby Goel, Yan-Fei Qi, Jasenka Zubcevic, Marcelo Febo, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Sustained captopril-Induced reduction in blood pressure is associated with alterations in gut-brain axis in the spontaneously hypertensive rat, Journal of the American Heart Association, 2019, 8(4):e010721. IF: 4.605.

  14. Xiao-Jing Yu, Yu-Wang Miao, Hong-Bao Li (共同一作), Qing Su, Kai-Li Liu, Li-Yan Fu, Yi-Kang Hou, Xiao-Lian Shi, Ying Li, Jian-Jun Mu, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Philip J Ebenezer, Joseph Francis, Yu-Ming Kang, Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension, Neuroscience Bulletin, 2019, 35(1):47-56.

  15. Hong-Bao Li, Chan-Juan Huo, Qing Su, Xiang Li, Juan Bai, Guo-Qing Zhu, Yu-Ming Kang, Exercise training attenuates proinflammatory cytokines, oxidative stress and modulates neurotransmitters in the rostral ventrolateral medulla of salt-induced hypertensive rats, Cellular Physiology and Biochemistry, 2018;48(3):1369-1381.

  16. Hong-Bao Li, Xiang Li, Chan-Juan Huo, Qing Su, Jing Guo, Zu-Yi Yuan, Guo-Qing Zhu, Xiao-Lian Shi, Jin-Jun Liu, Yu-Ming Kang, TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension, Toxicology and Applied Pharmacology, 2016, 305:93-102.

  17. Qiu-Yue Yi, Hong-Bao Li (共同一作), Jie Qi, Xiao-Jing Yu, Chan-Juan Huo, Xiang Li, Juan Bai, Hong-Li Gao, Bo Kou, Kai-Li Liu, Dong-Dong Zhang, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Lian Shi, Yu-Ming Kang, Toxicology letters, 2016, 262:105-113. Hong-Bao Li, Da-Nian Qin, Kang Cheng, Qing Su, Yu-Wang Miao, Jing Guo, Meng Zhang, Guo-Qing Zhu, Yu-Ming Kang, Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats, Scientific Reports, 2015, 5:11162.

  18. Hong-Bao Li, Da-Nian Qin, Yu-Ping Suo, Jing Guo, Qing Su, Yu-Wang Miao, Wen-Yan Sun, Qiu-Yue Yi, Wei Cui, Kang Cheng, Guo-Qing Zhu, Yu-Ming Kang, Blockade of salusin β in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy in salt-induced hypertensive rats, Journal of cardiovascular pharmacology, 2015, 66(4):323-331.

  19. Hong-Bao Li, Yan Lu, Jin-Jun Liu, Yu-Wang Miao, Tian-Zhen Zheng, Qing Su, Jie Qi, Hong Tan, Zu-Yi Yuan, Guo-Qing Zhu, Yu-Ming Kang, Salusin β within the nucleus tractus solitarii suppresses blood pressure via inhibiting the activities of presympathetic neurons in the rostral ventrolateral medulla in spontaneously hypertensive rats, Cardiovascular Toxicology, 2016, 16(3):223-234.

  20. Hong-Bao Li, Da-Nian Qin, Le Ma, Yu-Wang Miao, Dong-Mei Zhang, Yan Lu, Xin-Ai Song, Guo-Qing Zhu, Yu-Ming Kang, Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension, Toxicology and Applied Pharmacology, 2014, 279(2):141-149.

 

联系方式：

电子邮箱：hongbaoli1985@163.com or lhb15891752503@mail.xjtu.edu.cn

个人主页： http://gr.xjtu.edu.cn/web/lhb15891752503

联系地址：西安市雁塔西路76号医学部